Search Results - "Rolland, William B"

Early Brain Injury, an Evolving Frontier in Subarachnoid Hemorrhage Research by Fujii, Mutsumi, Yan, Junhao, Rolland, William B., Soejima, Yoshiteru, Caner, Basak, Zhang, John H.

“…Subarachnoid hemorrhage (SAH), predominantly caused by a ruptured aneurysm, is a devastating neurological disease that has a morbidity and mortality rate…”
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PPARγ-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats by Flores, Jerry J, Klebe, Damon, Rolland, William B, Lekic, Tim, Krafft, Paul R, Zhang, John H

“…Abstract Germinal matrix hemorrhage remains the leading cause of morbidity and mortality in preterm infants in the United States with little progress made in…”
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α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 Attenuates Early Brain Injury in a Perforation Model of Subarachnoid Hemorrhage in Rats by DURIS, Kamil, MANAENKO, Anatol, SUZUKI, Hidenori, ROLLAND, William B, KRAFFT, Paul R, ZHANG, John H

“…Early brain injury is an important pathological process after subarachnoid hemorrhage (SAH). The goal of this study was to evaluate whether the α7 nicotinic…”
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PHA-543613 Preserves Blood―Brain Barrier Integrity After Intracerebral Hemorrhage in Mice by KRAFFT, Paul R, CANER, Basak, KLEBE, Damon, ROLLAND, William B, JIPING TANG, ZHANG, John H

“…Blood-brain barrier disruption and consequent vasogenic edema formation codetermine the clinical course of intracerebral hemorrhage (ICH). This study examined…”
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Fingolimod confers neuroprotection through activation of Rac1 after experimental germinal matrix hemorrhage in rat pups by Rolland, William B., Krafft, Paul R., Lekic, Tim, Klebe, Damon, LeGrand, Julia, Weldon, Abby Jones, Xu, Liang, Zhang, John H.

“…Fingolimod, a sphingosine‐1‐phosphate receptor (S1PR) agonist, is clinically available to treat multiple sclerosis and is showing promise in treating stroke…”
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Fibroblast growth factors preserve blood–brain barrier integrity through RhoA inhibition after intracerebral hemorrhage in mice by Huang, Bin, Krafft, Paul R, Ma, Qingyi, Rolland, William B, Caner, Basak, Lekic, Tim, Manaenko, Anatol, Le, Mai, Tang, Jiping, Zhang, John H

“…Abstract Fibroblast growth factors (FGFs) maintain and promote vascular integrity; however whether FGFs protect the blood–brain barrier (BBB) after…”
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Neonatal brain hemorrhage (NBH) of prematurity: translational mechanisms of the vascular-neural network by Lekic, Tim, Klebe, Damon, Poblete, Roy, Krafft, Paul R, Rolland, William B, Tang, Jiping, Zhang, John H

“…Neonatal brain hemorrhage (NBH) of prematurity is an unfortunate consequence of preterm birth. Complications result in shunt dependence and long-term…”
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Delayed hyperbaric oxygen therapy induces cell proliferation through stabilization of cAMP responsive element binding protein in the rat model of MCAo-induced ischemic brain injury by Mu, Jun, Ostrowski, Robert P, Soejima, Yoshiteru, Rolland, William B, Krafft, Paul R, Tang, Jiping, Zhang, John H

“…Abstract Treatments that could extend the therapeutic window of opportunity for stroke patients are urgently needed. Early administration of hyperbaric oxygen…”
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Nanoerythropoietin Is 10-Times More Effective Than Regular Erythropoietin in Neuroprotection in a Neonatal Rat Model of Hypoxia and Ischemia by HAN CHEN, SPAGNOLI, Frederic, BURRIS, Michael, ROLLAND, William B, FAJILAN, Adriel, DOU, Huanyu, JIPING TANG, ZHANG, John H

“…Erythropoietin (EPO) has been demonstrated to possess significant neuroprotective effects in stroke. We determined if the nano-drug form of human recombinant…”
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Etiology of stroke and choice of models by Krafft, Paul R., Bailey, Emma L., Lekic, Tim, Rolland, William B., Altay, Orhan, Tang, Jiping, Wardlaw, Joanna M., Zhang, John H., Sudlow, Cathie L. M.

“…Animal models of stroke contribute to the development of better stroke prevention and treatment through studies investigating the pathophysiology of different…”
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Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage by Rolland, William B., Lekic, Tim, Krafft, Paul R., Hasegawa, Yu, Altay, Orhan, Hartman, Richard, Ostrowski, Robert, Manaenko, Anatol, Tang, Jiping, Zhang, John H.

“…T-lymphocytes promote cerebral inflammation, thus aggravating neuronal injury after stroke. Fingolimod, a sphingosine 1-phosphate receptor analog, prevents the…”
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FTY720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice by Rolland, 2nd, William B, Manaenko, Anatol, Lekic, Tim, Hasegawa, Yu, Ostrowski, Robert, Tang, Jiping, Zhang, John H

“…Intracerebral hemorrhage (ICH) accounts for 20% of all strokes and is the most devastating form across all stroke types. Lymphocytes have been shown to…”
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α7 Nicotinic Acetylcholine Receptor Agonism Confers Neuroprotection Through GSK-3β Inhibition in a Mouse Model of Intracerebral Hemorrhage by KRAFFT, Paul R, ALTAY, Orhan, ROLLAND, William B, DURIS, Kamil, LEKIC, Tim, JIPING TANG, ZHANG, John H

“…Perihematomal edema formation and consequent cell death contribute to the delayed brain injury evoked by intracerebral hemorrhage (ICH). We aimed to evaluate…”
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Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats by Fujii, Mutsumi, Sherchan, Prativa, Krafft, Paul R, Rolland, William B, Soejima, Yoshiteru, Zhang, John H

“…Abstract Early brain injury (EBI), following subarachnoid hemorrhage (SAH), comprises blood–brain barrier (BBB) disruption and consequent edema formation…”
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Dabigatran ameliorates post-haemorrhagic hydrocephalus development after germinal matrix haemorrhage in neonatal rat pups by Klebe, Damon, Flores, Jerry J, McBride, Devin W, Krafft, Paul R, Rolland, William B, Lekic, Tim, Zhang, John H

“…We aim to determine if direct thrombin inhibition by dabigatran will improve long-term brain morphological and neurofunctional outcomes and if potential…”
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α 7 Nicotinic Acetylcholine Receptor Stimulation Attenuates Neuroinflammation through JAK2-STAT3 Activation in Murine Models of Intracerebral Hemorrhage by Krafft, Paul R, McBride, Devin, Rolland, William B, Lekic, Tim, Flores, Jerry J, Zhang, John H

“…Accounting for high mortality and morbidity rates, intracerebral hemorrhage (ICH) remains one of the most detrimental stroke subtypes lacking a specific…”
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Correlation between subacute sensorimotor deficits and brain edema in two mouse models of intracerebral hemorrhage by Krafft, Paul R., McBride, Devin W., Lekic, Tim, Rolland, William B., Mansell, Charles E., Ma, Qingyi, Tang, Jiping, Zhang, John H.

“…•Brain edema after ICH is associated with clinical outcomes.•Brain edema and neurological function were tested in animal models.•Brain edema is correlated with…”
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Protease-Activated Receptor 1 and 4 Signal Inhibition Reduces Preterm Neonatal Hemorrhagic Brain Injury by Lekic, Tim, Klebe, Damon, McBride, Devin W, Manaenko, Anatol, Rolland, William B, Flores, Jerry J, Altay, Orhan, Tang, Jiping, Zhang, John H

“…BACKGROUND AND PURPOSE—This study examines the role of thrombin’s protease-activated receptor (PAR)-1, PAR-4 in mediating cyclooxygenase-2 and mammalian target…”
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Modeling intracerebral hemorrhage in mice: injection of autologous blood or bacterial collagenase by Krafft, Paul R, Rolland, William B, Duris, Kamil, Lekic, Tim, Campbell, Aaron, Tang, Jiping, Zhang, John H

“…Spontaneous intracerebral hemorrhage (ICH) defines a potentially life-threatening neurological malady that accounts for 10-15% of all stroke-related…”
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Intranasal IGF-1 Reduced Rat Pup Germinal Matrix Hemorrhage by Lekic, Tim, Flores, Jerry, Klebe, Damon, Doycheva, Desislava, Rolland, William B, Tang, Jiping, Zhang, John H

“…Germinal matrix hemorrhage (GMH) is the most devastating neurological problem of premature infants. Current treatment strategies are ineffective and brain…”
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