Search Results - "Rolka, Krzysztof"

Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides by Glavaš, Mladena, Gitlin-Domagalska, Agata, Dębowski, Dawid, Ptaszyńska, Natalia, Łęgowska, Anna, Rolka, Krzysztof

“…Human neurohormone vasopressin (AVP) is synthesized in overlapping regions in the hypothalamus. It is mainly known for its vasoconstricting abilities, and it…”
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Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials by Wong, Jack Ho, Ng, Tzi Bun, Chan, Helen Hei Ling, Liu, Qin, Man, Gene Chi Wai, Zhang, Chris Zhiyi, Guan, Suzhen, Ng, Charlene Cheuk Wing, Fang, Evandro Fei, Wang, Hexiang, Liu, Fang, Ye, Xiuyun, Rolka, Krzysztof, Naude, Ryno, Zhao, Shuang, Sha, Ou, Li, Chunman, Xia, Lixin

“…This article reviews mushrooms with anti-breast cancer activity. The mushrooms covered which are better known include the following: button mushroom Agaricus…”
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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells by Lica, Jan Jakub, Wieczór, Miłosz, Grabe, Grzegorz Jan, Heldt, Mateusz, Jancz, Marta, Misiak, Majus, Gucwa, Katarzyna, Brankiewicz, Wioletta, Maciejewska, Natalia, Stupak, Anna, Bagiński, Maciej, Rolka, Krzysztof, Hellmann, Andrzej, Składanowski, Andrzej

“…Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this…”
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Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity by Ptaszyńska, Natalia, Gucwa, Katarzyna, Olkiewicz, Katarzyna, Heldt, Mateusz, Serocki, Marcin, Stupak, Anna, Martynow, Dorota, Dębowski, Dawid, Gitlin-Domagalska, Agata, Lica, Jan, Łęgowska, Anna, Milewski, Sławomir, Rolka, Krzysztof

“…Seven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide…”
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Synthesis of Novel Arginine Building Blocks with Increased Lipophilicity Compatible with Solid-Phase Peptide Synthesis by Glavaš, Mladena, Gitlin-Domagalska, Agata, Ptaszyńska, Natalia, Starego, Dominika, Freza, Sylwia, Dębowski, Dawid, Helbik-Maciejewska, Aleksandra, Łęgowska, Anna, Gilon, Chaim, Rolka, Krzysztof

“…Arginine, due to the guanidine moiety, increases peptides' hydrophilicity and enables interactions with charged molecules, but at the same time, its presence…”
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Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity by Lica, Jan Jakub, Gucwa, Katarzyna, Heldt, Mateusz, Stupak, Anna, Maciejewska, Natalia, Ptaszyńska, Natalia, Łęgowska, Anna, Pradhan, Bhaskar, Gitlin-Domagalska, Agata, Dębowski, Dawid, Jakóbkiewicz-Banecka, Joanna, Rolka, Krzysztof

“…The fusion of penetrating peptides (PPs), e.g., cell penetration peptides (CPPs) or antimicrobial peptides (AMPs), together with antimicrobial agents is an…”
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New ribosome-inactivating proteins and other proteins with protein synthesis–inhibiting activities by Wong, Jack Ho, Bao, Hui, Ng, Tzi Bun, Chan, Helen Hei Ling, Ng, Charlene Cheuk Wing, Man, Gene Chi Wai, Wang, Hexiang, Guan, Suzhen, Zhao, Shuang, Fang, Evandro Fei, Rolka, Krzysztof, Liu, Qin, Li, Chunman, Sha, Ou, Xia, Lixin

“…Ribosome-inactivating proteins (RIPs) consist of three varieties. Type 1 RIPs are single-chained and approximately 30-kDa in molecular weight. Type 2 RIPs are…”
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Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery by Lesner, Adam, Łęgowska, Anna, Wysocka, Magdalena, Rolka, Krzysztof

“…This work is focused on SFTI-1, a member of the Bowman-Birk family of inhibitors. This 14 amino acid cyclic peptide exhibits several features i.e. compact…”
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Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities by Ptaszyńska, Natalia, Gucwa, Katarzyna, Olkiewicz, Katarzyna, Łȩgowska, Anna, Okońska, Joanna, Ruczyński, Jarosław, Gitlin-Domagalska, Agata, Dȩbowski, Dawid, Milewski, Sławomir, Rolka, Krzysztof

“…Recent studies have shown that modified human lactoferrin 20–31 fragment, named HLopt2, possesses antibacterial and antifungal activity. Thus, we decided to…”
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Design, Synthesis, and Antitumor Evaluation of an Opioid Growth Factor Bioconjugate Targeting Pancreatic Ductal Adenocarcinoma by Budka, Justyna, Debowski, Dawid, Mai, Shaoshan, Narajczyk, Magdalena, Hac, Stanislaw, Rolka, Krzysztof, Vrettos, Eirinaios I, Tzakos, Andreas G, Inkielewicz-Stepniak, Iwona

“…Pancreatic ductal adenocarcinoma (PDAC) presents a formidable challenge with high lethality and limited effective drug treatments. Its heightened metastatic…”
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New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets by Brankiewicz, Wioletta, Okońska, Joanna, Serbakowska, Katarzyna, Lica, Jan, Drab, Marek, Ptaszyńska, Natalia, Łęgowska, Anna, Rolka, Krzysztof, Szweda, Piotr

“…Infections of spp. etiology are frequently treated with azole drugs. Among azoles, the most widely used in the clinical scenario remains fluconazole (FLC)…”
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Biochemical and structural characterization of SplD protease from Staphylococcus aureus by Zdzalik, Michal, Kalinska, Magdalena, Wysocka, Magdalena, Stec-Niemczyk, Justyna, Cichon, Przemyslaw, Stach, Natalia, Gruba, Natalia, Stennicke, Henning R, Jabaiah, Abeer, Markiewicz, Michal, Kedracka-Krok, Sylwia, Wladyka, Benedykt, Daugherty, Patrick S, Lesner, Adam, Rolka, Krzysztof, Dubin, Adam, Potempa, Jan, Dubin, Grzegorz

“…Staphylococcus aureus is a dangerous human pathogen. A number of the proteins secreted by this bacterium are implicated in its virulence, but many of the…”
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Can Immobilized Artificial Membrane Chromatography Support the Characterization of Antimicrobial Peptide Origin Derivatives? by Ciura, Krzesimir, Ptaszyńska, Natalia, Kapica, Hanna, Pastewska, Monika, Łęgowska, Anna, Rolka, Krzysztof, Kamysz, Wojciech, Sawicki, Wiesław, Greber, Katarzyna E.

“…The emergence and spread of multiple drug-resistant bacteria strains caused the development of new antibiotics to be one of the most important challenges of…”
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Inhibition of human and yeast 20S proteasome by analogues of trypsin inhibitor SFTI-1 by Dębowski, Dawid, Pikuła, Michał, Lubos, Marta, Langa, Paulina, Trzonkowski, Piotr, Lesner, Adam, Łęgowska, Anna, Rolka, Krzysztof

“…Starting from the primary structure of sunflower trypsin inhibitor SFTI-1, we designed novel non-covalent inhibitors of human and yeast 20S proteasomes…”
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In Memoriam: Michael Przybylski (1948–2023)

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11th Austrian Peptide Symposium

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2022 Nobel Prize in Chemistry awarded to Morten Meldal

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Selenopeptide Analogs of EETI-II Retain Potent Trypsin Inhibitory Activities by Walewska, Aleksandra, Jaśkiewicz, Anna, Bulaj, Grzegorz, Rolka, Krzysztof

“…Three-disulfide-bridged Ecballium elaterium trypsin inhibitor II (EETI-II) is a 28-residue peptide that belongs to the squash family of canonical trypsin…”
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Design of selective substrates of proteinase 3 using combinatorial chemistry methods by Wysocka, Magdalena, Lesner, Adam, Guzow, Katarzyna, Mackiewicz, Lucyna, Łęgowska, Anna, Wiczk, Wiesław, Rolka, Krzysztof

“…In this study, chemical synthesis of the selective chromogenic/fluorogenic substrates for proteinase 3 is described. The substrates’ sequence was obtained…”
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The dimeric and tetrameric octarepeat fragments of prion protein behave differently to its monomeric unit by Valensin, Daniela, Luczkowski, Marek, Mancini, Francesca Maria, Legowska, Anna, Gaggelli, Elena, Valensin, Gianni, Rolka, Krzysztof, Kozlowski, Henryk

“…Potentiometric and spectroscopic data have shown that octarepeat dimer and tetramer are much more effective ligands for Cu(II) ions than simple octapeptide…”
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