Search Results - "Rolink, Antonius G."

The Immunogenicity of Antibody Aggregates in a Novel Transgenic Mouse Model by Bessa, Juliana, Boeckle, Sabine, Beck, Hermann, Buckel, Thomas, Schlicht, Sonja, Ebeling, Martin, Kiialainen, Anna, Koulov, Atanas, Boll, Björn, Weiser, Thomas, Singer, Thomas, Rolink, Antonius G., Iglesias, Antonio

“…Purpose Protein aggregates have been discussed as a potential risk factor related to immunogenicity. Here we developed a novel human IgG transgenic (tg) mouse…”
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Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells by Rauch, Melanie, Tussiwand, Roxane, Bosco, Nabil, Rolink, Antonius G

“…Defects in the expression of either BAFF (B cell activating factor) or BAFF-R impairs B cell development beyond the immature, transitional type-1 stage and…”
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BAFF receptor mAb treatment ameliorates development and progression of atherosclerosis in hyperlipidemic ApoE(-/-) mice by Kyaw, Tin, Cui, Peng, Tay, Christopher, Kanellakis, Peter, Hosseini, Hamid, Liu, Edgar, Rolink, Antonius G, Tipping, Peter, Bobik, Alex, Toh, Ban-Hock

“…Option to attenuate atherosclerosis by depleting B2 cells is currently limited to anti-CD20 antibodies which deplete all B-cell subtypes. In the present study…”
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Testosterone is an endogenous regulator of BAFF and splenic B cell number by Wilhelmson, Anna S., Lantero Rodriguez, Marta, Stubelius, Alexandra, Fogelstrand, Per, Johansson, Inger, Buechler, Matthew B., Lianoglou, Steve, Kapoor, Varun N., Johansson, Maria E., Fagman, Johan B., Duhlin, Amanda, Tripathi, Prabhanshu, Camponeschi, Alessandro, Porse, Bo T., Rolink, Antonius G., Nissbrandt, Hans, Turley, Shannon J., Carlsten, Hans, Mårtensson, Inga-Lill, Karlsson, Mikael C. I., Tivesten, Åsa

“…Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that…”
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BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells by Smulski, Cristian R., Kury, Patrick, Seidel, Lea M., Staiger, Hannah S., Edinger, Anna K., Willen, Laure, Seidl, Maximilan, Hess, Henry, Salzer, Ulrich, Rolink, Antonius G., Rizzi, Marta, Schneider, Pascal, Eibel, Hermann

“…B cell activating factor (BAFF) provides B cells with essential survival signals. It binds to three receptors: BAFFR, TACI, and BCMA that are differentially…”
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Enhancer repertoires are reshaped independently of early priming and heterochromatin dynamics during B cell differentiation by Choukrallah, Mohamed-Amin, Song, Shuang, Rolink, Antonius G., Burger, Lukas, Matthias, Patrick

“…A widely accepted model posits that activation of enhancers during differentiation goes through a priming step prior to lineage commitment. To investigate the…”
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A B220+ CD117+ CD19± hematopoietic progenitor with potent lymphoid and myeloid developmental potential by Balciunaite, Gina, Ceredig, Rod, Massa, Steffen, Rolink, Antonius G.

“…In this report, we identify in the bone marrow (BM) of normal mice a subpopulation of B220+ CD117+ CD19– NK1.1– cells with potent lymphoid and myeloid…”
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Transcriptional networks in developing and mature B cells by Matthias, Patrick, Rolink, Antonius G

“…The development of B cells from haematopoietic stem cells proceeds along a highly ordered, yet flexible, pathway. At multiple steps along this pathway, cells…”
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Flt3 Ligand Regulates the Development of Innate Lymphoid Cells in Fetal and Adult Mice by Baerenwaldt, Anne, von Burg, Nicole, Kreuzaler, Matthias, Sitte, Selina, Horvath, Edit, Peter, Annick, Voehringer, David, Rolink, Antonius G, Finke, Daniela

“…Flt3 ligand (Flt3L) promotes survival of lymphoid progenitors in the bone marrow and differentiation of dendritic cells (DCs), but its role in regulating…”
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A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency by Pieper, Kathrin, PhD, Rizzi, Marta, MD, PhD, Speletas, Matthaios, MD, PhD, Smulski, Cristian R., PhD, Sic, Heiko, PhD, Kraus, Helene, MSc, Salzer, Ulrich, MD, Fiala, Gina J., MSc, Schamel, Wolfgang W., PhD, Lougaris, Vassilios, MD, Plebani, Alessandro, MD, Hammarstrom, Lennart, MD, PhD, Recher, Mike, MD, Germenis, Anastasios E., MD, PhD, Grimbacher, Bodo, MD, Warnatz, Klaus, MD, PhD, Rolink, Antonius G., PhD, Schneider, Pascal, PhD, Notarangelo, Luigi D., MD, Eibel, Hermann, PhD

“…Superimposing the structural model of BAFFR on the CRD1 of TNFR1 shows that P21 corresponds to Q46 of TNFR1 (Fig E3, B), a residue involved in TNFR1-TNFR1…”
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A translocated effector required for Bartonella dissemination from derma to blood safeguards migratory host cells from damage by co-translocated effectors by Okujava, Rusudan, Guye, Patrick, Lu, Yun-Yueh, Mistl, Claudia, Polus, Florine, Vayssier-Taussat, Muriel, Halin, Cornelia, Rolink, Antonius G, Dehio, Christoph

“…Numerous bacterial pathogens secrete multiple effectors to modulate host cellular functions. These effectors may interfere with each other to efficiently…”
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BAFF is a survival and maturation factor for mouse B cells by Rolink, Antonius G., Tschopp, Jürg, Schneider, Pascal, Melchers, Fritz

“…Human B cell‐activating factor (BAFF) induces mouse surface IgM+ B cells of the immature type from bone marrow and of the immature types 1 and 2 from spleen,…”
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Commitment to the B-lymphoid lineage depends on the transcription factor Pax5 by Busslinger, Meinrad, Nutt, Stephen L, Heavey, Barry, Rolink, Antonius G

“…The Pax5 gene encoding the B-cell-specific activator protein (BSAP) is expressed within the haematopoietic system exclusively in the B-lymphoid lineage, where…”
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Tolerance checkpoints in B-cell development: Johnny B good by Tussiwand, Roxane, Bosco, Nabil, Ceredig, Rhodri, Rolink, Antonius G

“…B-cell development up to the immature B-cell stage takes place in the bone marrow, while final maturation into mature B cells occurs in the spleen. During…”
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The preTCR‐dependent DN3 to DP transition requires Notch signaling, is improved by CXCL12 signaling and is inhibited by IL‐7 signaling by Tussiwand, Roxane, Engdahl, Corinne, Gehre, Nadine, Bosco, Nabil, Ceredig, Rod, Rolink, Antonius G.

“…The requirement for Notch signaling during T‐cell development has been extensively studied. Nevertheless, the developmental stage at which it is required and…”
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Critical role for c‐kit (CD117) in T cell lineage commitment and early thymocyte development in vitro by Massa, Steffen, Balciunaite, Gina, Ceredig, Rhodri, Rolink, Antonius G.

“…The precise roles played by the transmembrane receptor tyrosine kinase c‐kit and its ligand stem cell factor in early T cell development are difficult to…”
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Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome by Cassani, Barbara, Poliani, Pietro Luigi, Marrella, Veronica, Schena, Francesca, Sauer, Aisha V, Ravanini, Maria, Strina, Dario, Busse, Christian E, Regenass, Stephan, Wardemann, Hedda, Martini, Alberto, Facchetti, Fabio, van der Burg, Mirjam, Rolink, Antonius G, Vezzoni, Paolo, Grassi, Fabio, Traggiai, Elisabetta, Villa, Anna

“…Hypomorphic RAG mutations, leading to limited V(D)J rearrangements, cause Omenn syndrome (OS), a peculiar severe combined immunodeficiency associated with…”
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The B lineage potential of thymus settling progenitors is critically dependent on mouse age by Ceredig, Rhodri, Bosco, Nabil, Rolink, Antonius G.

“…The nature and lineage potential, particularly that for B cells, of thymus settling progenitors (TSP) in the adult mouse has been the subject of considerable…”
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Regulatory T cells control autoimmunity following syngeneic bone marrow transplantation by Bénard, Angèle, Ceredig, Rhodri, Rolink, Antonius G.

“…Sublethally irradiated, immunodeficient, C57BL/6 RAG‐2 gene‐deleted recipient mice reconstituted with T cell‐depleted bone marrow (BM) grafts frequently…”
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The role of Notch and IL‐7 signaling in early thymocyte proliferation and differentiation by Balciunaite, Gina, Ceredig, Rhodri, Fehling, Hans‐Jörg, Zúñiga‐Pflücker, Juan‐Carlos, Rolink, Antonius G.

“…We have analyzed the roles of Notch and IL‐7 signaling in the proliferation and differentiation of mouse progenitor thymocyte subpopulations cultured on Notch…”
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