Lung diffusion capacity and quality of life 6 months after discharge from the ICU among survivors of acute respiratory distress syndrome due to influenza A H1N1

An evaluation is made of lung function and quality of life 6 months after discharge from the Intensive Care Unit (ICU) among survivors of acute respiratory distress syndrome (ARDS) due to pandemic 2009 influenza A H1N1, based on studies of lung function and the EQ-5D health questionnaire. Case serie...

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Bibliographic Details
Published in:	Medicina intensiva Vol. 36; no. 1; p. 15
Main Authors:	Quispe-Laime, A M, Fiore, C, González-Ros, M N, Bettini, J E, Rolfo, V E, Campagne, C G, Barberio, P A
Format:	Journal Article
Language:	Spanish
Published:	Spain 01-01-2012
Subjects:	Activities of Daily Living Adult Anxiety - epidemiology Argentina - epidemiology Convalescence - psychology Depression - epidemiology Female Follow-Up Studies Humans Influenza A Virus, H1N1 Subtype Influenza, Human - complications Intensive Care Units - statistics & numerical data Male Middle Aged Pain - epidemiology Pain Measurement Pulmonary Diffusing Capacity Quality of Life Respiratory Distress Syndrome, Adult - etiology Respiratory Distress Syndrome, Adult - physiopathology Respiratory Distress Syndrome, Adult - psychology Respiratory Distress Syndrome, Adult - therapy Severity of Illness Index Survivors - psychology Argentina
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Summary:	An evaluation is made of lung function and quality of life 6 months after discharge from the Intensive Care Unit (ICU) among survivors of acute respiratory distress syndrome (ARDS) due to pandemic 2009 influenza A H1N1, based on studies of lung function and the EQ-5D health questionnaire. Case series. The ICU of Dr. Leónidas Lucero Acute Cases Municipal Hospital, Bahía Blanca, Argentina. PATIENTS discharged from the ICU who had been admitted with ARDS in 2009 due to influenza A H1N1. Eleven patients were studied. Seven were positive for influenza H1N1 and four were negative. The mean age was 37±9.5 years, and 73% were males. Quality of life, as measured by the EQ-5D, showed changes in the 5 components in all patients, particularly in the pain/discomfort dimension 1.55±0.52; health status (EQ%health) was 70%±24. The indices adjusted for Argentina were Time Trade Off (TTO) 0.903±0.085 and Visual Analog Scale (VAS) 0.827±0.153. In all patients, spirometry and the study of pulmonary diffusion (DLCO) showed values of >80%. There was no correlation between lung diffusion and quality of life (%DLCO and EQ%health). A correlation was observed between quality of life and TTO (EQ%health and TTO), and between quality of life and the VAS score (EQ%health and VAS). Although the sample is small, our results suggest that patients with ARDS due to influenza A H1N1 evaluated 6 months after discharge from the ICU show no deterioration of lung function, and the impact on quality of life is moderate-in contrast to the situation found in patients with ARDS of other etiologies.
ISSN:	1578-6749
DOI:	10.1016/j.medin.2011.09.007