Search Results - "Rolfe, P."

Combination Therapy with NHS-muIL12 and Avelumab (anti-PD-L1) Enhances Antitumor Efficacy in Preclinical Cancer Models by Xu, Chunxiao, Zhang, Yanping, Rolfe, P Alexander, Hernández, Vivian M, Guzman, Wilson, Kradjian, Giorgio, Marelli, Bo, Qin, Guozhong, Qi, Jin, Wang, Hong, Yu, Huakui, Tighe, Robert, Lo, Kin-Ming, English, Jessie M, Radvanyi, Laszlo, Lan, Yan

“…To determine whether combination therapy with NHS-muIL12 and the anti-programmed death ligand 1 (PD-L1) antibody avelumab can enhance antitumor efficacy in…”
Get full text

Genotype to Phenotype: A Complex Problem by Dowell, Robin D, Ryan, Owen, Jansen, An, Cheung, Doris, Agarwala, Sudeep, Danford, Timothy, Bernstein, Douglas A, Rolfe, P. Alexander, Heisler, Lawrence E, Chin, Brian, Nislow, Corey, Giaever, Guri, Phillips, Patrick C, Fink, Gerald R, Gifford, David K, Boone, Charles

“…We generated a high-resolution whole-genome sequence and individually deleted 5100 genes in Σ1278b, a Saccharomyces cerevisiae strain closely related to…”
Get full text

Control of transcription by cell size by Wu, Chia-Yung, Rolfe, P Alexander, Gifford, David K, Fink, Gerald R

“…Cell size increases significantly with increasing ploidy. Differences in cell size and ploidy are associated with alterations in gene expression, although no…”
Get full text

Revealing the immune cell subtype reconstitution profile in patients from the CLARITY study using deconvolution algorithms after cladribine tablets treatment by Kalatskaya, Irina, Giovannoni, Gavin, Leist, Thomas, Cerra, Joseph, Boschert, Ursula, Rolfe, P. Alexander

“…Immune Cell Deconvolution methods utilizing gene expression profiling to quantify immune cells in tissues and blood are an appealing alternative to flow…”
Get full text

Control of Pancreas and Liver Gene Expression by HNF Transcription Factors by Odom, Duncan T., Zizlsperger, Nora, Gordon, D. Benjamin, Bell, George W., Rinaldi, Nicola J., Murray, Heather L., Volkert, Tom L., Schreiber, Jörg, Rolfe, P. Alexander, Gifford, David K., Fraenkel, Ernest, Bell, Graeme I., Young, Richard A.

“…The transcriptional regulatory networks that specify and maintain human tissue diversity are largely uncharted. To gain insight into this circuitry, we used…”
Get full text

Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies by Strauss, Julius, Gatti-Mays, Margaret E, Cho, Byoung Chul, Hill, Andrew, Salas, Sébastien, McClay, Edward, Redman, Jason M, Sater, Houssein A, Donahue, Renee N, Jochems, Caroline, Lamping, Elizabeth, Burmeister, Andrea, Marté, Jennifer L, Cordes, Lisa M, Bilusic, Marijo, Karzai, Fatima, Ojalvo, Laureen S, Jehl, Genevieve, Rolfe, P Alexander, Hinrichs, Christian S, Madan, Ravi A, Schlom, Jeffrey, Gulley, James L

“…BackgroundBintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of transforming growth factor (TGF)-βRII (a…”
Get full text

Tissue-specific transcriptional regulation has diverged significantly between human and mouse by Fraenkel, Ernest, Odom, Duncan T, Dowell, Robin D, Jacobsen, Elizabeth S, Gordon, William, Danford, Timothy W, MacIsaac, Kenzie D, Rolfe, P Alexander, Conboy, Caitlin M, Gifford, David K

“…We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four…”
Get full text

Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast by Pokholok, Dmitry K., Harbison, Christopher T., Levine, Stuart, Cole, Megan, Hannett, Nancy M., Lee, Tong Ihn, Bell, George W., Walker, Kimberly, Rolfe, P. Alex, Herbolsheimer, Elizabeth, Zeitlinger, Julia, Lewitter, Fran, Gifford, David K., Young, Richard A.

“…Eukaryotic genomes are packaged into nucleosomes whose position and chemical modification state can profoundly influence regulation of gene expression. We…”
Get full text

Comparison of Two Illumina Whole Transcriptome RNA Sequencing Library Preparation Methods Using Human Cancer FFPE Specimens by Wang, Danyi, Rolfe, P. Alexander, Foernzler, Dorothee, O’Rourke, Dennis, Zhao, Sheng, Scheuenpflug, Juergen, Feng, Zheng

“…Objective: RNA extraction and library preparation from formalin-fixed, paraffin-embedded (FFPE) samples are crucial pre-analytical steps towards achieving…”
Get full text

Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in advanced squamous cell carcinoma of the head and neck: results from a phase I cohort by Cho, Byoung Chul, Daste, Amaury, Ravaud, Alain, Salas, Sébastien, Isambert, Nicolas, McClay, Edward, Awada, Ahmad, Borel, Christian, Ojalvo, Laureen S, Helwig, Christoph, Rolfe, P Alexander, Gulley, James L, Penel, Nicolas

“…BackgroundWe report the clinical activity and safety of bintrafusp alfa, a first-in-class bifunctional fusion protein composed of the extracellular domain of…”
Get full text

Risk assessment of drug–drug interaction potential for bintrafusp alfa with cytochrome P4503A4 substrates: A totality of evidence approach by Vugmeyster, Yulia, Locke, George, Helwig, Christoph, Rolfe, P. Alexander, Dong, Jennifer Q., Venkatakrishnan, Karthik

“…Bintrafusp alfa, a first‐in‐class bifunctional fusion protein composed of the extracellular domain of TGF‐βRII (a TGF‐β “trap”) fused to a human IgG1 mAb…”
Get full text

Development and evaluation of a panel of filovirus sequence capture probes for pathogen detection by next-generation sequencing by Koehler, Jeffrey W, Hall, Adrienne T, Rolfe, P Alexander, Honko, Anna N, Palacios, Gustavo F, Fair, Joseph N, Muyembe, Jean-Jacques, Mulembekani, Prime, Schoepp, Randal J, Adesokan, Adeyemi, Minogue, Timothy D

“…A detailed understanding of the circulating pathogens in a particular geographic location aids in effectively utilizing targeted, rapid diagnostic assays, thus…”
Get full text

Identification of HMGA2 as a predictive biomarker of response to bintrafusp alfa in a phase 1 trial in patients with advanced triple-negative breast cancer by Spira, Alexander, Awada, Ahmad, Isambert, Nicolas, Lorente, David, Penel, Nicolas, Zhang, Yue, Ojalvo, Laureen S, Hicking, Christine, Rolfe, P Alexander, Ihling, Christian, Dussault, Isabelle, Locke, George, Borel, Christian

“…We report the clinical activity, safety, and identification of a predictive biomarker for bintrafusp alfa, a first-in-class bifunctional fusion protein…”
Get full text

Identification of tumor‐associated macrophage subsets that are associated with breast cancer prognosis by Strack, Elisabeth, Rolfe, P. Alexander, Fink, Annika F., Bankov, Katrin, Schmid, Tobias, Solbach, Christine, Savai, Rajkumar, Sha, Weixiao, Pradel, Leon, Hartmann, Sylvia, Brüne, Bernhard, Weigert, Andreas

“…Background Breast cancer is the leading cause of cancer‐related deaths in women, demanding new treatment options. With the advent of immune checkpoint…”
Get full text

Application of a coproantigen ELISA as an indicator of efficacy against multiple life stages of Fasciola hepatica infections in sheep by George, S.D., Vanhoff, K., Baker, K., Lake, L., Rolfe, P.F., Seewald, W., Emery, D.L.

“…[Display omitted] •Coproantigen ELISA (cELISA) correlated strongly with adult fluke burden (R2=0.78).•cELISA and FWEC combined can provide a non-lethal…”
Get full text

Comparative assessment of faecal diagnostics for detection and predictive modelling of endemic Fasciola hepatica infection in sheep and cattle on Australian farms by George, S.D., George, A.J., Rolfe, P.F., Emery, D.L.

“…[Display omitted] •FFEC and cELISA explained by parallel (R2 = 0.91) and series (R2 = 0.88) models.•Kappa agreement of FFEC and cELISA higher in cattle than…”
Get full text

Observational Study of PD-L1, TGF-β, and Immune Cell Infiltrates in Hepatocellular Carcinoma by Ihling, Christian, Naughton, Bartholomew, Zhang, Yue, Rolfe, P Alexander, Frick-Krieger, Eveline, Terracciano, Luigi M, Dussault, Isabelle

“…Hepatocellular carcinoma (HCC) typically develops in cirrhotic livers, with increased programed death ligand 1 (PD-L1) and transforming growth factor beta…”
Get full text

Identifying lupus Patient Subsets Through Immune Cell Deconvolution of Gene Expression Data in Two Atacicept Phase II Studies by Studham, Matthew, Vazquez‐Mateo, Cristina, Samy, Eileen, Haselmayer, Philipp, Aydemir, Aida, Rolfe, P. Alexander, Merrill, Joan T., Morand, Eric F., DeMartino, Julie, Kao, Amy, Townsend, Robert

“…ObjectiveTo use cell-based gene signatures to identify patients with systemic lupus erythematous (SLE) in the phase II/III APRIL–SLE and phase IIb ADDRESS II…”
Get full text

RLS adaptive filtering for physiological interference reduction in NIRS brain activity measurement: a Monte Carlo study by Zhang, Y, Sun, J W, Rolfe, P

“…The non-invasive measurement of cerebral functional haemodynamics using near-infrared spectroscopy (NIRS) instruments is often affected by physiological…”
Get more information

Characterization of multiple life stages of two Australian Fasciola hepatica isolates in sheep by George, S.D., Baker, K., Lake, L., Vanhoff, K., D’Arcy, R., Emery, D., Rolfe, P.F.

“…•The Oberon isolate confirmed as TCBZ-R in 6 and 10-week old F. hepatica.•Oberon isolate confirmed susceptible to ALB, salicylanilide and sulphonamide…”
Get full text