Search Results - "Rolas, Loïc"

Development of a CRISPR/Cas9-based therapy for Hutchinson–Gilford progeria syndrome by Santiago-Fernández, Olaya, Osorio, Fernando G., Quesada, Víctor, Rodríguez, Francisco, Basso, Sammy, Maeso, Daniel, Rolas, Loïc, Barkaway, Anna, Nourshargh, Sussan, Folgueras, Alicia R., Freije, José M. P., López-Otín, Carlos

“…CRISPR/Cas9-based therapies hold considerable promise for the treatment of genetic diseases. Among these, Hutchinson–Gilford progeria syndrome, caused by a…”
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Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage by Barkaway, Anna, Rolas, Loïc, Joulia, Régis, Bodkin, Jennifer, Lenn, Tchern, Owen-Woods, Charlotte, Reglero-Real, Natalia, Stein, Monja, Vázquez-Martínez, Laura, Girbl, Tamara, Poston, Robin N., Golding, Matthew, Saleeb, Rebecca S., Thiriot, Aude, von Andrian, Ulrich H., Duchene, Johan, Voisin, Mathieu-Benoit, Bishop, Cleo L., Voehringer, David, Roers, Axel, Rot, Antal, Lämmermann, Tim, Nourshargh, Sussan

“…Aging is associated with dysregulated immune functions. Here, we investigated the impact of age on neutrophil diapedesis. Using confocal intravital microscopy,…”
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Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson–Gilford Progeria Syndrome by Marcos-Ramiro, Beatriz, Gil-Ordóñez, Ana, Marín-Ramos, Nagore I, Ortega-Nogales, Francisco J, Balabasquer, Moisés, Gonzalo, Pilar, Khiar-Fernández, Nora, Rolas, Loïc, Barkaway, Anna, Nourshargh, Sussan, Andrés, Vicente, Martín-Fontecha, Mar, López-Rodríguez, María L, Ortega-Gutiérrez, Silvia

“…Hutchinson–Gilford progeria syndrome (HGPS, progeria) is a rare genetic disease characterized by premature aging and death in childhood for which there were no…”
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NADPH oxidase activation in neutrophils: Role of the phosphorylation of its subunits by Belambri, Sahra A., Rolas, Loïc, Raad, Houssam, Hurtado‐Nedelec, Margarita, Dang, Pham My‐Chan, El‐Benna, Jamel

“…Neutrophils are key cells of innate immunity and during inflammation. Upon activation, they produce large amounts of superoxide anion (O2−.) and ensuing…”
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Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis by Girbl, Tamara, Lenn, Tchern, Perez, Lorena, Rolas, Loïc, Barkaway, Anna, Thiriot, Aude, del Fresno, Carlos, Lynam, Eleanor, Hub, Elin, Thelen, Marcus, Graham, Gerard, Alon, Ronen, Sancho, David, von Andrian, Ulrich H., Voisin, Mathieu-Benoit, Rot, Antal, Nourshargh, Sussan

“…Neutrophils require directional cues to navigate through the complex structure of venular walls and into inflamed tissues. Here we applied confocal intravital…”
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Local microvascular leakage promotes trafficking of activated neutrophils to remote organs by Owen-Woods, Charlotte, Joulia, Régis, Barkaway, Anna, Rolas, Loïc, Ma, Bin, Nottebaum, Astrid Fee, Arkill, Kenton P, Stein, Monja, Girbl, Tamara, Golding, Matthew, Bates, David O, Vestweber, Dietmar, Voisin, Mathieu-Benoit, Nourshargh, Sussan

“…Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory…”
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Leukocyte Trafficking: Time to Take Time Seriously by Reglero-Real, Natalia, Rolas, Loïc, Nourshargh, Sussan

“…Leukocyte trafficking is a key component of steady-state tissue homing and in mounting an inflammatory response. Two recent publications in Immunity by He…”
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Impaired intracellular signaling, myeloperoxidase release and bactericidal activity of neutrophils from patients with alcoholic cirrhosis by Boussif, Abdelali, Rolas, Loïc, Weiss, Emmanuel, Bouriche, Hamama, Moreau, Richard, Périanin, Axel

“…Graphical abstract…”
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Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation by Reglero-Real, Natalia, Pérez-Gutiérrez, Lorena, Yoshimura, Azumi, Rolas, Loïc, Garrido-Mesa, José, Barkaway, Anna, Pickworth, Catherine, Saleeb, Rebeca S., Gonzalez-Nuñez, Maria, Austin-Williams, Shani N., Cooper, Dianne, Vázquez-Martínez, Laura, Fu, Tao, De Rossi, Giulia, Golding, Matthew, Voisin, Mathieu-Benoit, Boulanger, Chantal M., Kubota, Yoshiaki, Muller, William A., Tooze, Sharon A., Nightingale, Thomas D., Collinson, Lucy, Perretti, Mauro, Aksoy, Ezra, Nourshargh, Sussan

“…The migration of neutrophils from the blood circulation to sites of infection or injury is a key immune response and requires the breaching of endothelial…”
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NADPH oxidase depletion in neutrophils from patients with cirrhosis and restoration via toll-like receptor 7/8 activation by Rolas, Loïc, Boussif, Abdelali, Weiss, Emmanuel, Lettéron, Philippe, Haddad, Oualid, El-Benna, Jamel, Rautou, Pierre-Emmanuel, Moreau, Richard, Périanin, Axel

“…Cirrhosis downregulates phagocyte oxidant production via their antibacterial superoxide-generating system, NADPH oxidase (NOX2) and increases patients'…”
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Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome by Sánchez-López, Amanda, Espinós-Estévez, Carla, González-Gómez, Cristina, Gonzalo, Pilar, Andrés-Manzano, María J., Fanjul, Víctor, Riquelme-Borja, Raquel, Hamczyk, Magda R., Macías, Álvaro, del Campo, Lara, Camafeita, Emilio, Vázquez, Jesús, Barkaway, Anna, Rolas, Loïc, Nourshargh, Sussan, Dorado, Beatriz, Benedicto, Ignacio, Andrés, Vicente

“…Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder characterized by premature aging and death mainly because of myocardial infarction, stroke, or…”
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Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues by Rolas, Loïc, Stein, Monja, Barkaway, Anna, Reglero-Real, Natalia, Sciacca, Elisabetta, Yaseen, Mohammed, Wang, Haitao, Vazquez-Martinez, Laura, Golding, Matthew, Blacksell, Isobel A, Giblin, Meredith J, Jaworska, Edyta, Bishop, Cleo L, Voisin, Mathieu-Benoit, Gaston-Massuet, Carles, Fossati-Jimack, Liliane, Pitzalis, Costantino, Cooper, Dianne, Nightingale, Thomas D, Lopez-Otin, Carlos, Lewis, Myles J, Nourshargh, Sussan

“…Cellular senescence is a hallmark of advanced age and a major instigator of numerous inflammatory pathologies. While endothelial cell (EC) senescence is…”
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Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells by Benedicto, Ignacio, Carmona, Rosa M, Barettino, Ana, Espinós-Estévez, Carla, Gonzalo, Pilar, Nevado, Rosa M, de la Fuente-Pérez, Miguel, Andrés-Manzano, María J, González-Gómez, Cristina, Rolas, Loïc, Dorado, Beatriz, Nourshargh, Sussan, Hamczyk, Magda R, Andrés, Vicente

“…Hutchinson-Gilford progeria syndrome (HGPS) is a rare disease caused by the expression of progerin, a mutant protein that accelerates aging and precipitates…”
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Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment by Madjene, Lydia Celia, Danelli, Luca, Dahdah, Albert, Vibhushan, Shamila, Bex-Coudrat, Julie, Pacreau, Emeline, Vaugier, Celine, Claver, Julien, Rolas, Loïc, Pons, Maguelonne, Madera-Salcedo, Iris Karina, Beghdadi, Walid, El Ghoneimi, Alaa, Benhamou, Marc, Launay, Pierre, Abrink, Magnus, Pejler, Gunnar, Moura, Ivan Cruz, Charles, Nicolas, Daugas, Eric, Perianin, Axel, Blank, Ulrich

“…Here we investigated the role of murine mast cell protease 4 (MCPT4), the functional counterpart of human mast cell chymase, in an experimental model of renal…”
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Inhibition of mammalian target of rapamycin aggravates the respiratory burst defect of neutrophils from decompensated patients with cirrhosis by Rolas, Loïc, Makhezer, Nesrine, Hadjoudj, Soumeya, El‐Benna, Jamel, Djerdjouri, Bahia, Elkrief, Laure, Moreau, Richard, Périanin, Axel

“…Cirrhosis is commonly accompanied by impaired defense functions of polymorphonuclear leucocytes (PMNs), increased patient susceptibility to infections, and…”
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The Kinesin Light Chain-Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes by Arabi-Derkawi, Riad, O'Dowd, Yvonne, Cheng, Ni, Rolas, Loïc, Boussetta, Tarek, Raad, Houssam, Marzaioli, Viviana, Pintard, Coralie, Fasseu, Magali, Kroviarski, Yolande, Belambri, Sahra A, Dang, Pham My-Chan, Ye, Richard D, Gougerot-Pocidalo, Marie-Anne, El-Benna, Jamel

“…Superoxide anion production by the phagocyte NADPH oxidase plays a crucial role in host defenses and inflammatory reaction. The phagocyte NADPH oxidase is…”
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Cardiovascular Progerin Suppression and lamin A Restoration Rescues Hutchinson-Gilford Progeria Syndrome by Sánchez-López, Amanda, Espinós-Estévez, Carla, González-Gómez, Cristina, Gonzalo, Pilar, Andrés-Manzano, María J., Fanjul, Víctor, Riquelme-Borja, Raquel, Hamczyk, Magda R., Macías, Álvaro, del Campo, Lara, Camafeita, Emilio, Vázquez, Jesús, Barkaway, Anna, Rolas, Loïc, Nourshargh, Sussan, Dorado, Beatriz, Benedicto, Ignacio, Andrés, Vicente

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The Kinesin Light Chain–Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes by Arabi-Derkawi, Riad, O’dowd, Yvonne, Cheng, Ni, Rolas, Loïc, Boussetta, Tarek, Raad, Houssam, Marzaioli, Viviana, Pintard, Coralie, Fasseu, Magali, Kroviarski, Yolande, Belambri, Sahra A, Dang, Pham My-Chan, Ye, Richard D, Gougerot-Pocidalo, Marie-Anne, El-Benna, Jamel

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