Search Results - "Rol, Nina"

TGF-β and BMPR2 Signaling in PAH: Two Black Sheep in One Family by Rol, Nina, Kurakula, Konda Babu, Happé, Chris, Bogaard, Harm Jan, Goumans, Marie-José

“…Knowledge pertaining to the involvement of transforming growth factor β (TGF-β) and bone morphogenetic protein (BMP) signaling in pulmonary arterial…”
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Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells by Szulcek, Robert, Sanchez-Duffhues, Gonzalo, Rol, Nina, Pan, Xiaoke, Tsonaka, Roula, Dickhoff, Chris, Yung, Lai Ming, Manz, Xue D., Kurakula, Kondababu, Kiełbasa, Szymon M., Mei, Hailiang, Timens, Wim, Yu, Paul B., Bogaard, Harm-Jan, Goumans, Marie-José

“…Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are postulated to favor a pathological pulmonary endothelial…”
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The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient by Happé, Chris, Kurakula, Kondababu, Sun, Xiao-Qing, da Silva Goncalves Bos, Denielli, Rol, Nina, Guignabert, Christophe, Tu, Ly, Schalij, Ingrid, Wiesmeijer, Karien C, Tura-Ceide, Olga, Vonk Noordegraaf, Anton, de Man, Frances S, Bogaard, Harm Jan, Goumans, Marie-José

“…Mutations in bone morphogenetic protein receptor type II (BMPR2) are leading to the development of hereditary pulmonary arterial hypertension (PAH). In…”
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Endothelial dysfunction in pulmonary arterial hypertension: loss of cilia length regulation upon cytokine stimulation by Dummer, Anneloes, Rol, Nina, Szulcek, Robert, Kurakula, Kondababu, Pan, Xiaoke, Visser, Benjamin I., Bogaard, Harm Jan, DeRuiter, Marco C., Goumans, Marie-José, Hierck, Beerend P.

“…Pulmonary arterial hypertension (PAH) is a syndrome characterized by progressive lung vascular remodelling, endothelial cell (EC) dysfunction, and excessive…”
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P1.12 In Idiopathic Pulmonary Arterial Hypertension Arterial Narrowing is Limited and Heterogeneous by Rol, Nina, Timmer, Esther, Faes, Theo, Bogaard, Harm Jan, Noordegraaf, Anton Vonk, Grünberg, Katrien, Westerhof, Nico

“…Rationale In severe idiopathic pulmonary arterial hypertension, iPAH, pulmonary vascular resistance is increased due to remodeling of the small (resistance)…”
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SuHx rat model: partly reversible pulmonary hypertension and progressive intima obstruction by DE RAAF, Michiel Alexander, SCHALIJ, Ingrid, GOMEZ-ARROYO, Jose, ROL, Nina, HAPPE, Chris, DE MAN, Frances S, VONK-NOORDEGRAAF, Anton, WESTERHOF, Nico, VOELKEL, Norbert F, BOGAARD, Harm Jan

“…The SU5416 combined with hypoxia (SuHx) rat model features angio-obliterative pulmonary hypertension resembling human pulmonary arterial hypertension. Despite…”
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Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension: A View on the Right Ventricle by Van Der Bruggen, Cathelijne E.E, Happé, Chris M, Dorfmuller, Peter, Trip, Pia, Spruijt, Onno A, Rol, Nina, Hoevenaars, Femke P, Houweling, Arjan C, Girerd, Barbara, Marcus, Johannes T, Mercier, Olaf, Humbert, Marc, Handoko, M Louis, Van Der Velden, Jolanda, Noordegraaf, Anton Vonk, Bogaard, Harm Jan, Goumans, Marie-José, de Man, Frances S

“…BACKGROUND—The effect of a mutation in the bone morphogenetic protein receptor 2 gene (BMPR2) gene on right ventricular (RV) pressure overload in patients with…”
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Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension by da Silva Gonçalves Bós, Denielli, Van Der Bruggen, Cathelijne E E, Kurakula, Kondababu, Sun, Xiao-Qing, Casali, Karina R, Casali, Adenauer G, Rol, Nina, Szulcek, Robert, dos Remedios, Cris, Guignabert, Christophe, Tu, Ly, Dorfmüller, Peter, Humbert, Marc, Wijnker, Paul J.M, Kuster, Diederik W.D, van der Velden, Jolanda, Goumans, Marie-José, Bogaard, Harm-Jan, Vonk-Noordegraaf, Anton, de Man, Frances S, Handoko, M Louis

“…BACKGROUND:The beneficial effects of parasympathetic stimulation have been reported in left heart failure, but whether it would be beneficial for pulmonary…”
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Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage by Szulcek, Robert, Happé, Chris M, Rol, Nina, Fontijn, Ruud D, Dickhoff, Chris, Hartemink, Koen J, Grünberg, Katrien, Tu, Ly, Timens, Wim, Nossent, George D, Paul, Marinus A, Leyen, Thomas A, Horrevoets, Anton J, de Man, Frances S, Guignabert, Christophe, Yu, Paul B, Vonk-Noordegraaf, Anton, van Nieuw Amerongen, Geerten P, Bogaard, Harm J

“…Altered pulmonary hemodynamics and fluid flow-induced high shear stress (HSS) are characteristic hallmarks in the pathogenesis of pulmonary arterial…”
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Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension by Rol, Nina, de Raaf, Michiel A, Sun, Xiaoqing Q, Kuiper, Vincent P, da Silva Gonçalves Bos, Denielli, Happé, Chris, Kurakula, Kondababu, Dickhoff, Chris, Thuillet, Raphael, Tu, Ly, Guignabert, Christophe, Schalij, Ingrid, Lodder, Kirsten, Pan, Xiaoke, Herrmann, Franziska E, van Nieuw Amerongen, Geerten P, Koolwijk, Pieter, Vonk-Noordegraaf, Anton, de Man, Frances S, Wollin, Lutz, Goumans, Marie-José, Szulcek, Robert, Bogaard, Harm J

“…Abstract Aims Pulmonary arterial hypertension (PAH) is associated with increased levels of circulating growth factors and corresponding receptors such as…”
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Vascular remodelling in the pulmonary circulation after major lung resection by Rol, Nina, Happé, Chris, Beliën, Jeroen A M, de Man, Frances S, Westerhof, Nico, Vonk-Noordegraaf, Anton, Grünberg, Katrien, Bogaard, Harm J

“…Lung resection is a standard treatment in patients with clinical stages I and II and selected patients with stage IIIA nonsmall cell lung cancer [1]. Major…”
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Abstract 19602: Characterization of Tgfβ/BMP-axis in Multiple Animal Models of PH by Happé, Chris, Rol, Nina, Da Silva Goncalves Bos, Denielli, van der Bruggen, Cathelijne, Vonk-Noordegraaf, Anton, de Man, Frances, Bogaard, Harm Jan

“…IntroductionMutations in the bone morphogenetic protein recptor type 2 (BMPR2) comprise a large portion of familial Pulmonary Arterial Hypertension (PAH)…”
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Vascular narrowing in pulmonary arterial hypertension is heterogeneous: rethinking resistance by Rol, Nina, Timmer, Esther M., Faes, Theo J.C., Vonk Noordegraaf, Anton, Grünberg, Katrien, Bogaard, Harm‐Jan, Westerhof, Nico

“…In idiopathic pulmonary arterial hypertension (PAH), increased pulmonary vascular resistance is associated with structural narrowing of small (resistance)…”
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Abstract 10300: The Effects of the Bone Morphogenetic Protein Receptor Type 2 Mutation on the Right Ventricle in Pulmonary Arterial Hypertension by van der Bruggen, Cathelijne E, Happé, Chris, Trip, Pia, Spruijt, Onno A, Rol, Nina, Houweling, Arjan C, Girerd, Barbara, Dorfmüller, Peter, Mercier, Olaf, Humbert, Marc, Handoko, Louis M, van der Velden, Jolanda, Vonk Noordegraaf, Anton, Bogaard, Harm Jan, Goumans, Marie José, de Man, Frances S

“…IntroductionThe effects of a mutation in the bone morphogenetic protein receptor 2 gene (BMPR2) gene on right ventricular (RV)adaptation are currently unknown…”
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In idiopathic pulmonary arterial hypertension arterial narrowing is limited and heterogeneous by Rol, Nina, Timmer, Esther, Faes, Theo, Bogaard, Harm Jan, Noordegraaf, Anton Vonk, Grünberg, Katrien, Westerhof, Nico

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