Search Results - "Rokosh, Gregg D"

Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial by Bolli, Roberto, Prof, Chugh, Atul R, MD, D'Amario, Domenico, MD, Loughran, John H, MD, Stoddard, Marcus F, Prof, Ikram, Sohail, Prof, Beache, Garth M, MD, Wagner, Stephen G, MD, Leri, Annarosa, MD, Hosoda, Toru, MD, Sanada, Fumihiro, MD, Elmore, Julius B, MD, Goichberg, Polina, PhD, Cappetta, Donato, PhD, Solankhi, Naresh K, MD, Fahsah, Ibrahim, MD, Rokosh, D Gregg, PhD, Slaughter, Mark S, Prof, Kajstura, Jan, PhD, Anversa, Piero, Prof

“…Summary Background c-kit-positive, lineage-negative cardiac stem cells (CSCs) improve post-infarction left ventricular (LV) dysfunction when administered to…”
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Cardioprotective and Antiapoptotic Effects of Heme Oxygenase-1 in the Failing Heart by GUANGWU WANG, HAMID, Tariq, FORD, Rachael, SPINALE, Francis G, RIGGS, Daniel W, SRIVASTAVA, Sanjay, BHATNAGAR, Aruni, BOLLI, Roberto, PRABHU, Sumanth D, KEITH, Rachel J, GUIHUA ZHOU, PARTRIDGE, Charles R, XILIN XIANG, KINGERY, Justin R, LEWIS, Robert K, QIANHONG LI, ROKOSH, D. Gregg

“…Heme oxygenase-1 (HO-1) is an inducible stress-response protein that imparts antioxidant and antiapoptotic effects. However, its pathophysiological role in…”
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Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia–Reperfusion Injury by Conklin, Daniel J, Guo, Yiru, Jagatheesan, Ganapathy, Kilfoil, Peter J, Haberzettl, Petra, Hill, Bradford G, Baba, Shahid P, Guo, Luping, Wetzelberger, Karin, Obal, Detlef, Rokosh, D Gregg, Prough, Russell A, Prabhu, Sumanth D, Velayutham, Murugesan, Zweier, Jay L, Hoetker, J David, Riggs, Daniel W, Srivastava, Sanjay, Bolli, Roberto, Bhatnagar, Aruni

“…RATIONALE:Myocardial ischemia–reperfusion (I/R) results in the generation of oxygen-derived free radicals and the accumulation of lipid peroxidation–derived…”
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Cardiac Progenitor Cells and Bone Marrow-Derived Very Small Embryonic-Like Stem Cells for Cardiac Repair After Myocardial Infarction by Tang, Xian-Liang, Rokosh, D. Gregg, Guo, Yiru, Bolli, Roberto

“…Heart failure after myocardial infarction (MI) continues to be the most prevalent cause of morbidity and mortality worldwide. Although pharmaceutical agents…”
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The cardioprotection of the late phase of ischemic preconditioning is enhanced by postconditioning via a COX-2-mediated mechanism in conscious rats by Sato, Hiroshi, Bolli, Roberto, Rokosh, Gregg D, Bi, Qiuli, Dai, Shujing, Shirk, Gregg, Tang, Xian-Liang

“…The present study sought to determine whether the combination of late preconditioning (PC) with postconditioning enhances the reduction in infarct size…”
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Autonomous and Growth Factor–Induced Hypertrophy in Cultured Neonatal Mouse Cardiac Myocytes: Comparison With Rat by Deng, Xing-Fei, Rokosh, D Gregg, Simpson, Paul C

“…ABSTRACT—Cultured neonatal rat cardiac myocytes have been used extensively to study cellular and molecular mechanisms of cardiac hypertrophy. However, there…”
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Knockout of the α1A/C-Adrenergic Receptor Subtype: The α1A/C is Expressed in Resistance Arteries and is Required to Maintain Arterial Blood Pressure by Rokosh, D. Gregg, Simpson, Paul C.

“…α1-adrenergic receptors (ARs) play a major role in blood pressure regulation. The three α1-AR subtypes (A/C, B, and D) stimulate contraction of isolated…”
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Gene Transfer of Inducible Nitric Oxide Synthase Affords Cardioprotection by Upregulating Heme Oxygenase-1 Via a Nuclear Factor-κB-Dependent Pathway by QIANHONG LI, YIRU GUO, SHINMURA, Ken, ROKOSH, Gregg D, SHUYAN WANG, BOLLI, Roberto, QINGHUI OU, CHUANJUE CUI, WU, Wen-Jian, WEI TAN, XIAOPING ZHU, LANCETA, Lilibeth B, SANGANALMATH, Santosh K, DAWN, Buddhadeb

“…Background— Although inducible nitric oxide synthase (iNOS) is known to impart powerful protection against myocardial infarction, the mechanism for this…”
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The α1A/C- and α1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse by O’Connell, Timothy D., Ishizaka, Shinji, Nakamura, Akihiro, Swigart, Philip M., Rodrigo, M.C., Simpson, Gregory L., Cotecchia, Susanna, Rokosh, D. Gregg, Grossman, William, Foster, Elyse, Simpson, Paul C.

“…Catecholamines and α 1 -adrenergic receptors (α 1 -ARs) cause cardiac hypertrophy in cultured myocytes and transgenic mice, but heart size is normal in single…”
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Cigarette smoke adversely affects functions and cell membrane integrity in c-kit+ cardiac stem cells by Sumanasekera, Wasana K., Tran, David M., Sumanasekera, Thimira U., Le, Nolan, Dao, Halle T., Rokosh, Gregg D.

“…Cigarette smoking is a major risk factor for numerous diseases including cardiovascular diseases. Exposure to cigarette smoke (CS) leads to increased…”
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RETRACTED: Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial by Bolli, Roberto, Chugh, Atul R, D'Amario, Domenico, Loughran, John H, Stoddard, Marcus F, Ikram, Sohail, Beache, Garth M, Wagner, Stephen G, Leri, Annarosa, Hosoda, Toru, Sanada, Fumihiro, Elmore, Julius B, Goichberg, Polina, Cappetta, Donato, Solankhi, Naresh K, Fahsah, Ibrahim, Rokosh, D Gregg, Slaughter, Mark S, Kajstura, Jan, Anversa, Piero

“…c-kit-positive, lineage-negative cardiac stem cells (CSCs) improve post-infarction left ventricular (LV) dysfunction when administered to animals. We undertook…”
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Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure by Rokosh, D Gregg, Simpson, Paul C

“…alpha 1-adrenergic receptors (ARs) play a major role in blood pressure regulation. The three alpha 1-AR subtypes (A/C, B, and D) stimulate contraction of…”
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Abstract 15555: Administration of c-Kit+ Cardiac Stem Cells (CSCs) Results in Increased Proliferation and Cardiac Content of CSCs 1 Year Later by Li, Qianhong, Chen, Ning, Luo, Li, Ou, Qinghui, Xie, Wei, Hunt, Gregory N, Tang, Xian-Liang, Rokosh, Gregg D, Bolli, Roberto

“…Abstract only Background: We have previously shown in rats that the beneficial effects of c-kit + CSCs on LV function and remodeling post-myocardial infarction…”
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The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse by O'Connell, Timothy D, Ishizaka, Shinji, Nakamura, Akihiro, Swigart, Philip M, Rodrigo, M C, Simpson, Gregory L, Cotecchia, Susanna, Rokosh, D Gregg, Grossman, William, Foster, Elyse, Simpson, Paul C

“…Catecholamines and alpha(1)-adrenergic receptors (alpha(1)-ARs) cause cardiac hypertrophy in cultured myocytes and transgenic mice, but heart size is normal in…”
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α1-Adrenergic Receptor Subtype mRNAs Are Differentially Regulated by α1-Adrenergic and Other Hypertrophic Stimuli in Cardiac Myocytes in Culture and In Vivo by Rokosh, D. Gregg, Stewart, Alexandre F.R., Chang, Kevin C., Bailey, Beth A., Karliner, Joel S., Camacho, S. Albert, Long, Carlin S., Simpson, Paul C.

“…The three cloned α1-adrenergic receptor (AR) subtypes, α1B, α1C, and α1D, can all couple to the same effector, phospholipase C, and the reason(s) for…”
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Effect of Cardiac Stem Cells in Patients with Ischemic Cardiomyopathy: Initial Results of the SCIPIO Trial by Bolli, Roberto, Chugh, Atul R., D’Amario, Domenico, Loughran, John H., Stoddard, Marcus F., Ikram, Sohail, Beache, Garth M., Wagner, Stephen G., Leri, Annarosa, Hosoda, Toru, Elmore, Julius B., Goihberg, Polina, Cappetta, Donato, Solankhi, Naresh K., Fahsah, Ibrahim, Rokosh, D. Gregg, Slaughter, Mark S., Kajstura, Jan, Anversa, Piero

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Abstract 1614: Inducible Nitric Oxide Synthase Upregulates Heme Oxygenase-1 (HO-1) in Myocardium by Enhancing Nrf2 Phosphorylation and Binding to the HO-1 Promoter by Li, Qianhong, Ou, Qinghui, Tan, Wei, Wu, Wen-Jian, Zhu, Xiaoping, Lanceta, Lilibeth B, Rokosh, Gregg D, Guo, Yiru, Bolli, Roberto

“…Abstract only Previous studies have shown that iNOS gene transfer leads to elevated expression of HO-1, which in turn protects against ischemic injury…”
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GENE TRANSFER OF INDUCIBLE NITRIC OXIDE SYNTHASE AFFORDS CARDIOPROTECTION BY UPREGULATING HEME OXYGENASE-1 VIA AN NF-κB-DEPENDENT PATHWAY by Li, Qianhong, Guo, Yiru, Ou, Qinghui, Cui, Chuanjue, Wu, Wen-Jian, Tan, Wei, Zhu, Xiaoping, Lanceta, Lilibeth B, Sanganalmath, Santosh K., Dawn, Buddhadeb, Shinmura, Ken, Rokosh, Gregg D., Wang, Shuyan, Bolli, Roberto

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CARDIOPROTECTIVE AND ANTI-APOPTOTIC EFFECTS OF HEME OXYGENASE-1 IN THE FAILING HEART by Wang, Guangwu, Hamid, Tariq, Keith, Rachel J., Zhou, Guihua, Partridge, Charles R., Xiang, Xilin, Kingery, Justin R., Lewis, Robert K., Li, Qianhong, Rokosh, D. Gregg, Ford, Rachael, Spinale, Francis G., Riggs, Daniel W., Srivastava, Sanjay, Bhatnagar, Aruni, Bolli, Roberto, Prabhu, Sumanth D.

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LV systolic performance improves with development of hypertrophy after transverse aortic constriction in mice by Nakamura, A, Rokosh, D G, Paccanaro, M, Yee, R R, Simpson, P C, Grossman, W, Foster, E

“…Transverse aortic constriction (TAC) is an effective technique for inducing left ventricular (LV) hypertrophy in mice. With the use of transthoracic…”
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