Search Results - "Rokita, Steven E."

Dynamic Cross-Linking Is Retained in Duplex DNA after Multiple Exchange of Strands by Wang, Huan, Rokita, Steven E

“…Strands may come and go, but cross‐linking is forever: Dynamic combinatorial chemistry can respond to changing environments, a characteristic that is now…”
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Inducible Alkylation of DNA by a Quinone Methide–Peptide Nucleic Acid Conjugate by Liu, Yang, Rokita, Steven E

“…The reversibility of alkylation by a quinone methide intermediate (QM) avoids the irreversible consumption that plagues most reagents based on covalent…”
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A new solvatochromic fluorophore for exploring nonpolar environments created by biopolymers by Fakhari M, Abulfazl, Rokita, Steven E

“…The fluorescence of a new aminocyanonaphthalene exhibits exquisite sensitivity to its environment and responds to a solvent change from water to hexane with…”
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A Mammalian Reductive Deiodinase has Broad Power to Dehalogenate Chlorinated and Brominated Substrates by McTamney, Patrick M, Rokita, Steven E

“…Iodotyrosine deiodinase is essential for iodide homeostasis and proper thyroid function in mammals. This enzyme promotes a net reductive deiodination of…”
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Few constraints limit the design of quinone methide-oligonucleotide self-adducts for directing DNA alkylation by Rossiter, Clifford S, Modica, Emilia, Kumar, Dalip, Rokita, Steven E

“…Nucleotide sequences minimally containing adenosine, cytosine or guanosine are sufficient to form intrastrand oligonucleotide quinone methide self-adducts…”
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Immortalizing a Transient Electrophile for DNA Cross-Linking by Wang, Huan, Wahi, Manvinder S, Rokita, Steven E

“…Who wants to live forever? Compounds that act as strong nucleophiles and good leaving groups repeatedly capture and release a transient quinone methide to…”
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Oxidative Quenching of Quinone Methide Adducts Reveals Transient Products of Reversible Alkylation in Duplex DNA by McCrane, Michael P, Hutchinson, Mark A, Ad, Omer, Rokita, Steven E

“…ortho-Quinone methides (ortho-QM) and para-quinone methides are generated by xenobiotic metabolism of numerous compounds including environmental toxins and…”
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Polar Interactions between Substrate and Flavin Control Iodotyrosine Deiodinase Function by Lemen, Daniel, Rokita, Steven E.

“…Flavin cofactors offer a wide range of chemical mechanisms to support a great diversity in catalytic function. As a corollary, such diversity necessitates…”
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Crystal Structure of Iodotyrosine Deiodinase, a Novel Flavoprotein Responsible for Iodide Salvage in Thyroid Glands by Thomas, Seth R., McTamney, Patrick M., Adler, Jennifer M., LaRonde-LeBlanc, Nicole, Rokita, Steven E.

“…The flavoprotein iodotyrosine deiodinase (IYD) salvages iodide from mono- and diiodotyrosine formed during the biosynthesis of the thyroid hormone thyroxine…”
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Efficient use and recycling of the micronutrient iodide in mammals by Rokita, Steven E., Adler, Jennifer M., McTamney, Patrick M., Watson, James A.

“…Daily ingestion of iodide alone is not adequate to sustain production of the thyroid hormones, tri- and tetraiodothyronine. Proper maintenance of iodide in…”
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Excess Electron Transfer from an Internally Conjugated Aromatic Amine to 5-Bromo-2‘-deoxyuridine in DNA by Ito, Takeo, Rokita, Steven E

“…DNA duplexes containing an N,N,N ‘,N ‘-tetramethyl-1,5-diaminonaphthalene analogue and 5-bromo-2‘-deoxyuridine (BrdU) provide a readily accessible system for…”
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Criteria for Efficient Transport of Excess Electrons in DNA by Ito, Takeo, Rokita, Steven E.

“…Better molecular wires could result from an improved understanding of the effects of nucleotide sequence on the efficiency of excess electron transfer in DNA…”
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Changing Selectivity of DNA Oxidation from Deoxyribose to Guanine by Ligand Design and a New Binuclear Copper Complex by Li, Lei, Karlin, Kenneth D, Rokita, Steven E

“…A dinuclear copper complex [CuII 2(PD‘O)(H2O)2]3+ (1) (where PD‘OH is a pyridylalkylamine containing binucleating ligand) promotes guanine oxidation in…”
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Hydrogen Peroxide and Dioxygen Activation by Dinuclear Copper Complexes in Aqueous Solution: Hydroxyl Radical Production Initiated by Internal Electron Transfer by Zhu, Qing, Lian, Yuxiang, Thyagarajan, Sunita, Rokita, Steven E, Karlin, Kenneth D, Blough, Neil V

“…Dinuclear Cu(II) complexes, CuII 2 N n ( n = 4 or 5), were recently found to specifically cleave DNA in the presence of a reducing thiol and O2 or in the…”
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Targeted Strand Scission of DNA Substrates by a Tricopper(II) Coordination Complex by Humphreys, Kristi J, Karlin, Kenneth D, Rokita, Steven E

“…A trinuclear copper complex, [Cu3 II(L)(H2O)3(NO3)2](NO3)4·5H2O (1) (L = 2,2‘,2‘ ‘-tris(dipicolylamino)triethylamine), with pyridyl and alkylamine coordination…”
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Single Amino Acid Switch between a Flavin-Dependent Dehalogenase and Nitroreductase by Mukherjee, Arnab, Rokita, Steven E

“…A single mutation within a flavo­protein is capable of switching the catalytic activity of a dehalogenase into a nitro­reductase. This change in function…”
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Misregulation of bromotyrosine compromises fertility in male Drosophila by Su, Qi, Xu, Bing, Chen, Xin, Rokita, Steven E

“…Biological regulation often depends on reversible reactions such as phosphorylation, acylation, methylation, and glycosylation, but rarely halogenation. A…”
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A General Strategy for Target-Promoted Alkylation in Biological Systems by Zhou, Qibing, Rokita, Steven E.

“…Selective alkylation of a chosen sequence of DNA typically relies on ligand-directed delivery of a compound that expresses an intrinsic reactivity. A…”
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Substrate Electronics Dominate the Rate of Reductive Dehalogenation Promoted by the Flavin-Dependent Iodotyrosine Deiodinase by Kozyryev, Anton, Lemen, Daniel, Dunn, Jessica, Rokita, Steven E.

“…Iodotyrosine deiodinase (IYD) is unusual in its reliance on flavin to promote reductive dehalogenation of halotyrosines under aerobic conditions. Applications…”
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A Switch between One- and Two-electron Chemistry of the Human Flavoprotein Iodotyrosine Deiodinase Is Controlled by Substrate by Hu, Jimin, Chuenchor, Watchalee, Rokita, Steven E.

“…Reductive dehalogenation is not typical of aerobic organisms but plays a significant role in iodide homeostasis and thyroid activity. The flavoprotein…”
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