Search Results - "Rokhlin, Oskar"

p53 is a suppressor of inflammatory response in mice by Komarova, Elena A, Krivokrysenko, Vadim, Wang, Kaihua, Neznanov, Nickolay, Chernov, Mikhail V, Komarov, Pavel G, Brennan, Marie-Luise, Golovkina, Tatiana V, Rokhlin, Oskar W, Kuprash, Dmitry V, Nedospasov, Sergei A, Hazen, Stanley L, Feinstein, Elena, Gudkov, Andrei V

“…ABSTRACTChronic inflammation is known to promote cancer, suggesting that negative regulation of inflammation is likely to be tumor suppressive. We found that…”
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MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer by Rokhlin, Oskar W, Scheinker, Vladimir S, Taghiyev, Agshin F, Bumcrot, David, Glover, Rebecca A, Cohen, Michael B.

“…We investigated whether knocking down AR expression effects apoptosis after treatment with different apoptosis-inducing agents. We found that siRNA AR (si-AR)…”
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Mechanisms of prostate cancer cell survival after inhibition of AR expression by Cohen, Michael B., Rokhlin, Oskar W.

“…Recent reports have shown that the AR is the key determinant of the molecular changes required for driving prostate cancer cells from an androgen‐dependent to…”
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TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status by Guseva, Natalya V., Rokhlin, Oskar W., Glover, Rebecca A., Cohen, Michael B.

“…A key player in prostate cancer development and progression is the androgen receptor (AR). Tumor-associated lipogenesis can protect cancer cells from…”
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Calcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival by Rokhlin, Oskar, Taghiyev, Agshin F., Bayer, K. Ulrich, Bumcrot, David, Kotelianski, Victor E, Glover, Rebecca A., Cohen, Michael B.

“…It has recently been shown that the androgen receptor (AR) is the main factor that required for prostate cancer cells survival. We show that knocking down AR…”
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KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer by Rokhlin, Oskar, Guseva, Natalya V., Taghiyev, Agshin F., Glover, Rebecca A., Cohen, Michael B.

“…It has been suggested that the down-regulation of AR expression should be considered the principal strategy for the treatment of hormone-refractory prostate…”
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Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor by Guseva, Natalya V, Rokhlin, Oskar W, Bair, Thomas B, Glover, Rebecca B, Cohen, Michael B

“…The androgen receptor (AR) is known to play a critical role in prostate cancer (PC). p53 likely also plays a role given that p53 mutations are commonly found…”
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P53 and the proteasome regulate androgen receptor activity by Guseva, Natalya V., Rokhlin, Oskar W., Glover, Rebecca A., Cohen, Michael B.

“…Mutual regulation of expression between p53 and AR has been reported. To further investigate the role of p53 in the regulation of AR expression, an…”
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Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis by Komarov, Andrei P, Rokhlin, Oskar W, Yu, Chang-An, Gudkov, Andrei V

“…Functional selection of genetic suppressor elements (GSEs), engineered gene fragments that interfere with the function of a particular gene product, was used…”
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Chemotherapeutic Agents Up-regulate the Cytomegalovirus Promoter : Implications for Bioluminescence Imaging of Tumor Response to Therapy by SVENSSON, Robert U, BARNES, J. Matthew, ROKHLIN, Oskar W, COHEN, Michael B, HENRY, Michael D

“…Bioluminescence imaging is widely used to evaluate tumor growth and response to therapy in living animals. In cells expressing luciferase under the control of…”
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Mechanisms of Cell Death Induced by Histone Deacetylase Inhibitors in Androgen Receptor–Positive Prostate Cancer Cells by Rokhlin, Oskar W, Glover, Rebecca B, Guseva, Natalya V, Taghiyev, Agshin F, Kohlgraf, Karl G, Cohen, Michael B

“…Histone deacetylase inhibitors (HDACI) are potential therapeutic agents that inhibit tumor cell growth and survival. Although there are several publications…”
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Androgen regulates apoptosis induced by TNFR family ligands via multiple signaling pathways in LNCaP by ROKHLIN, Oskar W, TAGHIYEV, Agshin F, GUSEVA, Natalya V, GLOVER, Rebecca A, CHUMAKOV, Peter M, KRAVCHENKO, Julia E, COHEN, Michael B

“…It has been suggested in many studies that combined treatment with chemotherapeutic agents and apoptosis-inducing ligands belonging to TNFR family is a more…”
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Unique resistance of breast carcinoma cell line T47D to TRAIL but not anti-Fas is linked to p43cFLIP(L) by Guseva, Natalya V, Rokhlin, Oskar W, Taghiyev, Agshin F, Cohen, Michael B

“…The majority of breast cancer cell lines are resistant to tumor necrosis factor -related apoptosis inducing ligand (TRAIL) induced apoptosis. TRAIL and Fas…”
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Unique resistance of breast carcinoma cell line T47D to TRAIL but not anti-Fas is linked to p43cFLIPL by Guseva, Natalya V., Rokhlin, Oskar W., Taghiyev, Agshin F., Cohen, Michael B.

“…The majority of breast cancer cell lines are resistant to tumor necrosis factor -related apoptosis inducing ligand (TRAIL) induced apoptosis. TRAIL and Fas…”
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Caspase-2-Based Regulation of the Androgen Receptor and Cell Cycle in the Prostate Cancer Cell Line LNCaP by Taghiyev, Agshin F, Rokhlin, Oskar W, Glover, Rebecca B

“…Caspase-2 can induce apoptosis in response to extrinsic and intrinsic signals. Unlike other caspases, this protein is not expressed solely in nonnuclear…”
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Trichostatin a (TSA) sensitizes the human prostatic cancer cell line DU145 to death receptor ligands treatment by Taghiyev, Agshin F., Guseva, Natalya V., Sturm, Mary T., Rokhlin, Oskar, Cohen, Michael B.

“…The human prostatic carcinoma cell line DU145 has previously been found to be resistant to treatment with TNF-family ligands. However, TRAIL, TNF-α, and…”
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Prostate cancer-specific monoclonal antibody 5D4 significantly enhances the cytotoxicity of doxorubicin-loaded liposomes against target cells in vitro by Sawant, Rishikesh M., Cohen, Michael B., Torchilin, Vladimir P., Rokhlin, Oskar W.

“…Long-circulating liposomes loaded with doxorubicin (Dox) were additionally modified with the prostate cell-specific monoclonal antibody 5D4 (mAb 5D4). The…”
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Stress-induced secretion of growth inhibitors : a novel tumor suppressor function of p53 by KOMAROVA, E. A, DIATCHENKO, L, ROKHLIN, O. W, HILL, J. E, WANG, Z. J, KRIVOKRYSENKO, V. I, FEINSTEIN, E, GUDKOV, A. V

“…p53 tumor suppressor gene controls cell response to a variety of stresses inducing growth arrest or apoptosis in damaged cells. It largely determines the…”
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Death receptor-induced cell death in prostate cancer by Guseva, Natalya V., Taghiyev, Agshin F., Rokhlin, Oskar W., Cohen, Michael B.

“…Prostate cancer mortality results from metastasis and is often coupled with progression from androgen‐dependent to androgen‐independent growth. Unfortunately,…”
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Fas-mediated apoptosis in human prostatic carcinoma cell lines by ROKHLIN, O. W, BISHOP, G. A, HOSTAGER, B. S, WALDSCHMIDT, T. J, SIDORENKO, S. P, PAVLOFF, N, KIEFER, M. C, UMANSKY, S. R, GLOVER, R. A, COHEN, M. B

“…Of six prostatic carcinoma cell lines examined (ALVA31, DU145, JCA1, LNCaP, ND1, and PC3) by flow cytometric analysis, all were found to be positive for Fas…”
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