Search Results - "Rokad, Dharmin"

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein by Harischandra, Dilshan S, Rokad, Dharmin, Neal, Matthew L, Ghaisas, Shivani, Manne, Sireesha, Sarkar, Souvarish, Panicker, Nikhil, Zenitsky, Gary, Jin, Huajun, Lewis, Mechelle, Huang, Xuemei, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G

“…The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of certain neurodegenerative disorders, collectively termed…”
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Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells by Sarkar, Souvarish, Rokad, Dharmin, Malovic, Emir, Luo, Jie, Harischandra, Dilshan S, Jin, Huajun, Anantharam, Vellareddy, Huang, Xuemei, Lewis, Mechelle, Kanthasamy, Arthi, Kanthasamy, Anumantha G

“…Chronic, sustained inflammation underlies many pathological conditions, including neurodegenerative diseases. Divalent manganese (Mn ) exposure can stimulate…”
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Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events by Singh, Neeraj, Lawana, Vivek, Luo, Jie, Phong, Phang, Abdalla, Ahmed, Palanisamy, Bharathi, Rokad, Dharmin, Sarkar, Souvarish, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Anumantha G., Kanthasamy, Arthi

“…The organophosphate (OP) pesticide chlorpyrifos (CPF), used in agricultural settings, induces developmental and neurological impairments. Recent studies using…”
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Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease by Gordon, Richard, Singh, Neeraj, Lawana, Vivek, Ghosh, Anamitra, Harischandra, Dilshan S, Jin, Huajun, Hogan, Colleen, Sarkar, Souvarish, Rokad, Dharmin, Panicker, Nikhil, Anantharam, Vellareddy, Kanthasamy, Anumantha G, Kanthasamy, Arthi

“…Abstract Chronic microglial activation has been linked to the progressive degeneration of the nigrostriatal dopaminergic neurons evidenced in Parkinson's…”
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Epitranscriptomic reader YTHDF2 regulates SEK1(MAP2K4)-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress by Malovic, Emir, Ealy, Alyssa, Miller, Cameron, Jang, Ahyoung, Hsu, Phillip J., Sarkar, Souvarish, Rokad, Dharmin, Goeser, Cody, Hartman, Aleah Kristen, Zhu, Allen, Palanisamy, Bharathi, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, He, Chuan, Kanthasamy, Anumantha G.

“…As the most abundant glial cells in the central nervous system (CNS), astrocytes dynamically respond to neurotoxic stress, however, the key molecular…”
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Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia by Panicker, Nikhil, Sarkar, Souvarish, Harischandra, Dilshan S, Neal, Matthew, Kam, Tae-In, Jin, Huajun, Saminathan, Hariharan, Langley, Monica, Charli, Adhithiya, Samidurai, Manikandan, Rokad, Dharmin, Ghaisas, Shivani, Pletnikova, Olga, Dawson, Valina L, Dawson, Ted M, Anantharam, Vellareddy, Kanthasamy, Anumantha G, Kanthasamy, Arthi

“…Persistent microglia-mediated neuroinflammation is a major pathophysiological contributor to the progression of Parkinson's disease (PD), but the…”
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Exosomes in Toxicology: Relevance to Chemical Exposure and Pathogenesis of Environmentally Linked Diseases by Harischandra, Dilshan S, Ghaisas, Shivani, Rokad, Dharmin, Kanthasamy, Anumantha G

“…Chronic exposure to environmental toxins has been known to initiate or aggravate various neurological disorders, carcinomas and other adverse health effects…”
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Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease by Sarkar, Souvarish, Nguyen, Hai M, Malovic, Emir, Luo, Jie, Langley, Monica, Palanisamy, Bharathi N, Singh, Neeraj, Manne, Sireesha, Neal, Matthew, Gabrielle, Michelle, Abdalla, Ahmed, Anantharam, Poojya, Rokad, Dharmin, Panicker, Nikhil, Singh, Vikrant, Ay, Muhammet, Charli, Adhithiya, Harischandra, Dilshan, Jin, Lee-Way, Jin, Huajun, Rangaraju, Srikant, Anantharam, Vellareddy, Wulff, Heike, Kanthasamy, Anumantha G

“…Characterization of the key cellular targets contributing to sustained microglial activation in neurodegenerative diseases, including Parkinson's disease (PD),…”
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Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal neurotoxicity by Harischandra, Dilshan S., Ghaisas, Shivani, Rokad, Dharmin, Zamanian, Mostafa, Jin, Huajun, Anantharam, Vellareddy, Kimber, Michael, Kanthasamy, Arthi, Kanthasamy, Anumantha G.

“…[Display omitted] •Exposure to an environmental neurotoxin, Mn, can actively modulate exosome RNA cargo.•Mn induces Rab27a to increase extracellular RNA via…”
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Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes by Sarkar, Souvarish, Malovic, Emir, Harischandra, Dilshan S., Ngwa, Hilary A., Ghosh, Anamitra, Hogan, Colleen, Rokad, Dharmin, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Anumantha G., Kanthasamy, Arthi

“…•Mn induces mitochondrial dysfunction in astrocytes.•Mn exposure induces inflammatory response in astrocytes and exacerbates αSynagg-induced inflammatory…”
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Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease by Sarkar, Souvarish, Malovic, Emir, Harishchandra, Dilshan S., Ghaisas, Shivani, Panicker, Nikhil, Charli, Adhithiya, Palanisamy, Bharathi N., Rokad, Dharmin, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G.

“…The NLRP3 inflammasome signaling pathway is a major contributor to the neuroinflammatory process in the central nervous system. Oxidative stress and…”
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Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson's disease by Harischandra, Dilshan S., Rokad, Dharmin, Ghaisas, Shivani, Verma, Saurabh, Robertson, Alan, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G.

“…Human-derived neuronal cell lines are progressively being utilized in understanding neurobiology and preclinical translational research as they are…”
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Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation by Rokad, Dharmin, Ghaisas, Shivani, Harischandra, Dilshan S, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G

“…Graphical abstract…”
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Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults by Sarkar, Souvarish, Malovic, Emir, Sarda, Deeksha, Lawana, Vivek, Rokad, Dharmin, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G.

“…•BV2s have a high basal inflammatory state and are desensitized cells.•MMCs are more suitable than BV2s for studying neuro-inflammation and -toxicology.•MMCs…”
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Manganese Exposure Enhances the Release of Misfolded α-Synuclein via Exosomes by Impairing Endosomal Trafficking and Protein Degradation Mechanisms by Rokad, Dharmin, Harischandra, Dilshan S., Samidurai, Manikandan, Chang, Yuan-Teng, Luo, Jie, Lawana, Vivek, Sarkar, Souvarish, Palanisamy, Bharathi N., Manne, Sireesha, Kim, Dongsuk, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Willette, Auriel, Kanthasamy, Arthi, Kanthasamy, Anumantha G.

“…Excessive exposure to manganese (Mn) increases the risk of chronic neurological diseases, including Parkinson’s disease (PD) and other related Parkinsonisms…”
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Exosomes as Mediators of Chemical-Induced Toxicity by Rokad, Dharmin, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G.

“…Purpose of Review This review provides information regarding how exosomes may contribute to environmental chemical-induced pathogenesis of chronic diseases. In…”
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Manganese Exposure Activates NLRP3 Inflammasome Signaling and Propagates Exosomal Release of ASC in Microglial Cells by Malovic, Emir, Sarkar, Souvarish, Rokad, Dharmin, Luo, Jie, Harischandra, Dilshan, Jin, Huajun, Anantharam, Vellareddy, Huang, Xuemei, Lewis, Mechelle, Kanthasamy, Arthi, Kanthasamy, Anumantha

“…Abnormal metal homeostasis is a key hallmark of multiple neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Toxicological exposure to…”
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Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to a-synuclein misfolding in metal neurotoxicity by Harischandra, Dilshan S, Ghaisas, Shivani, Rokad, Dharmin, Zamanian, Mostafa, Jin, Huajun, Anantharam, Vellareddy, Kimber, Michael, Kanthasamy, Arthi, Kanthasamy, Anumantha G

“…Many chronic neurodegenerative disorders share a common pathogenic mechanism involving the aggregation and deposition of misfolded proteins. Recently, it was…”
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Role of Manganese Toxicity on Endosomal Trafficking, Exosomal Proteins and Potential Biomarkers Identification for Parkinson’s Disease by Rokad, Dharmin Devendrabhai

“…Parkinson’s disease (PD) is an enduring multifaceted neurological condition affecting 1% of the populace more than 60 years old, and its prevalence increases…”
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Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease by Gordon, Richard, Singh, Neeraj, Lawana, Vivek, Ghosh, Anamitra, Harischandra, Dilshan S., Jin, Huajun, Hogan, Colleen, Sarkar, Souvarish, Rokad, Dharmin, Panicker, Nikhil, Anantharam, Vellareddy, Kanthasamy, Anumantha G., Kanthasamy, Arthi

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