Search Results - "Rokach, J"

Biochemistry, biology and chemistry of the 5-lipoxygenase product 5-oxo-ETE by Powell, William S., Rokach, Joshua

“…5-Oxo-ETE (5-oxo-6,8,11,14-eicosatetraenoic acid) is an arachidonic acid metabolite formed by the oxidation of 5 S-hydroxy-6,8,11,14-eicosatetraenoic acid…”
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Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning by Kadiiska, M B, Gladen, B C, Baird, D D, Graham, L B, Parker, C E, Ames, B N, Basu, S, Fitzgerald, G A, Lawson, J A, Marnett, L J, Morrow, J D, Murray, D M, Plastaras, J, Roberts, 2nd, L J, Rokach, J, Shigenaga, M K, Sun, J, Walter, P B, Tomer, K B, Barrett, J C, Mason, R P

“…Plasma and urinary levels of malondialdehyde-like products (MDA) and isoprostanes were identified as markers of in vivo lipid peroxidation in an animal model…”
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Localization of distinct F2-isoprostanes in human atherosclerotic lesions by Praticò, D, Iuliano, L, Mauriello, A, Spagnoli, L, Lawson, J A, Rokach, J, Maclouf, J, Violi, F, FitzGerald, G A

“…F2-Isoprostanes are prostaglandin (PG) isomers formed in situ in cell membranes by peroxidation of arachidonic acid. 8-epi PGF2alpha and IPF2alpha-I are…”
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The Isoprostanes: A Perspective by Rokach, J., Khanapure, S.P., Hwang, S.-W., Adiyaman, M., Lawson, J.A., FitzGerald, G.A.

“…The isoprostanes are a new class of natural products produced in vivo by a non-enzymatic free-radical-induced peroxidation of polyunsaturated fatty acid. In…”
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Leukotrienes, lipoxins, and hydroxyeicosatetraenoic acids by Spokas, E G, Rokach, J, Wong, P Y

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Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist by Jones, T R, Zamboni, R, Belley, M, Champion, E, Charette, L, Ford-Hutchinson, A W, Frenette, R, Gauthier, J Y, Leger, S, Masson, P

“…L-660,711 (3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl) ((3-dimethyl amino-3-oxo propyl)thio)methyl)thio)propanoic acid is a potent and selective competitive…”
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L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor by Gillard, J, Ford-Hutchinson, A W, Chan, C, Charleson, S, Denis, D, Foster, A, Fortin, R, Leger, S, McFarlane, C S, Morton, H

“…L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid) is a potent inhibitor of leukotriene (LT) biosynthesis in…”
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Arachidonic acid metabolism in purified human lung mast cells by Peters, SP, MacGlashan, DW, Jr, Schulman, ES, Schleimer, RP, Hayes, EC, Rokach, J, Adkinson, NF, Jr, Lichtenstein, LM

“…Arachidonic acid metabolism has been explored in preparations of purified human lung mast cells prelabeled with arachidonic acid (AA). Cells were of 83 to…”
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Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor by Monneret, Guillaume, Gravel, Sylvie, Diamond, Michael, Rokach, Joshua, Powell, William S.

“…Prostaglandin D2 (PGD2) is released following exposure of asthmatics to allergen and acts via the adenylyl cyclase–coupled receptor for PGD2 (DP receptor). In…”
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Quantification of Lipid Mediator Metabolites in Human Urine from Asthma Patients by Electrospray Ionization Mass Spectrometry: Controlling Matrix Effects by Balgoma, David, Larsson, Johan, Rokach, Joshua, Lawson, John A, Daham, Kameran, Dahlén, Barbro, Dahlén, Sven-Erik, Wheelock, Craig E

“…Eicosanoids (e.g., prostaglandins and leukotrienes) are inflammatory signaling molecules that are metabolized and excreted in urine. The quantification of…”
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Effects of metabolites of leukotriene B4 on human neutrophil migration and cytosolic calcium levels by Powell, W S, Rokach, J, Khanapure, S P, Manna, S, Hashefi, M, Gravel, S, Macleod, R J, Falck, J R, Bhatt, R K

“…Leukotriene B4 (LTB4) is metabolized by beta-oxidation, omega-oxidation and the 12-hydroxyeicosanoid dehydrogenase/delta 10-reductase pathway. We have…”
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Measuring leukotrienes of slow reacting substance of anaphylaxis: development of a specific radioimmunoassay by Hayes, EC, Lombardo, DL, Girard, Y, Maycock, AL, Rokach, J, Rosenthal, AS, Young, RN, Egan, RW, Zweerink, HJ

“…Rabbits were immunized with leukotriene C4 (LTC4) coupled to thiolated keyhole limpet hemocyanin (KLH) by using 6-N-maleimidohexanoic acid as a spacer…”
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Development of a novel series of styrylquinoline compounds as high-affinity leukotriene D4 receptor antagonists: synthetic and structure-activity studies leading to the discovery of (.+-.)-3-[[[3-[2-(7-chloro-2-quinolinyl)-(E)-ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid by Zamboni, R, Belley, M, Champion, E, Charette, L, DeHaven, R, Frenette, R, Gauthier, J. Y, Jones, T. R, Leger, S

“…Based on LTD4 receptor antagonist activity of 3-(2-quinolinyl-(E)-ethenyl)pyridine (2) found in broad screening, structure-activity studies were carried out…”
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Increased F 2 ‐isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo by Pratico, Domenico, Lee, Virginia M.-Y., Trojanowski, John Q., Rokach, Joshua, Fitzgerald, Garret A.

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Stereochemical requirements for substrate specificity of LTB4 20-hydroxylase by Soberman, R J, Okita, R T, Fitzsimmons, B, Rokach, J, Spur, B, Austen, K F

“…LTB4 20-hydroxylase (P-450LTB) is the cytochrome P-450 in the microsomes of human polymorphonuclear leukocytes that catalyzes the omega-oxidation of…”
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Isoprostanes: Formation, Analysis and Use As Indices of Lipid Peroxidation in Vivo by Lawson, John A., FitzGerald, Garret A., Rokach, Joshua

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Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice by FitzGerald, Garret A, Praticò, Domenico, Tangirala, Rajendra K, Rader, Daniel J, Rokach, Joshua

“…Oxidative modification of low density lipoprotein (LDL) has been implicated in atherogenesis. Evidence consistent with this hypothesis includes the presence of…”
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Effects of Vitamin E on Lipid Peroxidation in Healthy Persons by Meagher, Emma A, Barry, Orla P, Lawson, John A, Rokach, Joshua, FitzGerald, Garret A

“…CONTEXT Oxidative stress may play a role in the development or exacerbation of many common diseases. However, results of prospective controlled trials of the…”
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Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trials by Quinn, Joseph, Kulhanek, Doris, Nowlin, Jessica, Jones, Richard, Praticò, Domenico, Rokach, Joshua, Stackman, Robert

“…Melatonin has been proposed as a treatment for Alzheimer's disease based on the demonstration of antioxidant and “anti-amyloid” effects in vitro and in vivo…”
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Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid by GRANT, Gail E, RUBINO, Stephen, GRAVEL, Sylvie, XIAOPING WANG, PATEL, Pranav, ROKACH, Joshua, POWELL, William S

“…The 5-lipoxygenase (5-LO) product 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), which is a potent chemoattractant for myeloid cells, is known to promote…”
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