Search Results - "Rojo, I."

Inflammation in Parkinson's Disease: Mechanisms and Therapeutic Implications by Pajares, Marta, I Rojo, Ana, Manda, Gina, Boscá, Lisardo, Cuadrado, Antonio

“…Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized by the death of dopaminergic neurons that project from the substantia…”
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Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases by Cuadrado, Antonio, Rojo, Ana I., Wells, Geoffrey, Hayes, John D., Cousin, Sharon P., Rumsey, William L., Attucks, Otis C., Franklin, Stephen, Levonen, Anna-Liisa, Kensler, Thomas W., Dinkova-Kostova, Albena T.

“…The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2 ) and its principal negative regulator, the E3 ligase adaptor Kelch-like…”
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Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases by Pajares, Marta, Cuadrado, Antonio, Rojo, Ana I.

“…Neurodegenerative diseases are linked to the accumulation of specific protein aggregates, suggesting an intimate connection between injured brain and loss of…”
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Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A by Pajares, Marta, Rojo, Ana I, Arias, Esperanza, Díaz-Carretero, Antonio, Cuervo, Ana María, Cuadrado, Antonio

“…Chaperone-mediated autophagy (CMA) is a selective degradative process for cytosolic proteins that contributes to the maintenance of proteostasis. The signaling…”
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SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner by Rada, Patricia, Rojo, Ana I., Chowdhry, Sudhir, McMahon, Michael, Hayes, John D., Cuadrado, Antonio

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes by Pajares, Marta, Jiménez-Moreno, Natalia, García-Yagüe, Ángel J., Escoll, Maribel, de Ceballos, María L., Van Leuven, Fred, Rábano, Alberto, Yamamoto, Masayuki, Rojo, Ana I., Cuadrado, Antonio

“…Autophagy is a highly coordinated process that is controlled at several levels including transcriptional regulation. Here, we identify the transcription factor…”
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Redox control of microglial function: molecular mechanisms and functional significance by Rojo, Ana I, McBean, Gethin, Cindric, Marina, Egea, Javier, López, Manuela G, Rada, Patricia, Zarkovic, Neven, Cuadrado, Antonio

“…Neurodegenerative diseases are characterized by chronic microglial over-activation and oxidative stress. It is now beginning to be recognized that reactive…”
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Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism by Jazwa, Agnieszka, Rojo, Ana I, Innamorato, Nadia G, Hesse, Marlen, Fernández-Ruiz, Javier, Cuadrado, Antonio

“…Current therapies for motor symptoms of Parkinson's disease (PD) are based on dopamine replacement. However, the disease progression remains unaffected,…”
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On the Clinical Pharmacology of Reactive Oxygen Species by Casas, Ana I, Nogales, Cristian, Mucke, Hermann A M, Petraina, Alexandra, Cuadrado, Antonio, Rojo, Ana I, Ghezzi, Pietro, Jaquet, Vincent, Augsburger, Fiona, Dufrasne, Francois, Soubhye, Jalal, Deshwal, Soni, Di Sante, Moises, Kaludercic, Nina, Di Lisa, Fabio, Schmidt, Harald H H W

“…Reactive oxygen species (ROS) have been correlated with almost every human disease. Yet clinical exploitation of these hypotheses by pharmacological modulation…”
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Functional Connectivity Hypersynchronization in Relatives of Alzheimer’s Disease Patients: An Early E/I Balance Dysfunction? by Ramírez-Toraño, F, Bruña, R, de Frutos-Lucas, J, Rodríguez-Rojo, I C, Marcos de Pedro, S, Delgado-Losada, M L, Gómez-Ruiz, N, Barabash, A, Marcos, A, López Higes, R, Maestú, F

“…Abstract Alzheimer’s disease (AD) studies on animal models, and humans showed a tendency of the brain tissue to become hyperexcitable and hypersynchronized,…”
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NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology by Rojo, Ana I., Pajares, Marta, Rada, Patricia, Nuñez, Angel, Nevado-Holgado, Alejo J., Killik, Richard, Van Leuven, Fred, Ribe, Elena, Lovestone, Simon, Yamamoto, Masayuki, Cuadrado, Antonio

“…Failure to translate successful neuroprotective preclinical data to a clinical setting in Alzheimer's disease (AD) indicates that amyloidopathy and tauopathy…”
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Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis by Rada, Patricia, Rojo, Ana I., Evrard-Todeschi, Nathalie, Innamorato, Nadia G., Cotte, Axelle, Jaworski, Tomasz, Tobón-Velasco, Julio C., Devijver, Herman, García-Mayoral, María Flor, Van Leuven, Fred, Hayes, John D., Bertho, Gildas, Cuadrado, Antonio

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Alpha band disruption in the AD-continuum starts in the Subjective Cognitive Decline stage: a MEG study by López-Sanz, D., Bruña, R., Garcés, P., Camara, C., Serrano, N., Rodríguez-Rojo, I. C., Delgado, M. L., Montenegro, M., López-Higes, R., Yus, M., Maestú, F.

“…The consideration of Subjective Cognitive Decline (SCD) as a preclinical stage of AD remains still a matter of debate. Alpha band alterations represent one of…”
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The PTEN/NRF2 axis promotes human carcinogenesis by Rojo, Ana I, Rada, Patricia, Mendiola, Marta, Ortega-Molina, Ana, Wojdyla, Katarzyna, Rogowska-Wrzesinska, Adelina, Hardisson, David, Serrano, Manuel, Cuadrado, Antonio

“…A recent study conducted in mice reported that liver-specific knockout of tumor suppressor Pten augments nuclear factor (erythroid-derived 2)-like 2 (NRF2)…”
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Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases by Manda, Gina, Rojo, Ana I, Martínez-Klimova, Elena, Pedraza-Chaverri, José, Cuadrado, Antonio

“…Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from , the creosote bush found in Mexico and USA deserts, that has been used in traditional…”
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Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3 by Rojo, Ana I., Medina-Campos, Omar Noel, Rada, Patricia, Zúñiga-Toalá, Adverqueydi, López-Gazcón, Areli, Espada, Sandra, Pedraza-Chaverri, José, Cuadrado, Antonio

“…Defense against oxidative stress is executed by an antioxidant program that is tightly controlled by the transcription factor Nrf2. The stability of Nrf2…”
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Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy by Rojo, Ana I., Pajares, Marta, García-Yagüe, Angel J., Buendia, Izaskun, Van Leuven, Fred, Yamamoto, Masayuki, López, Manuela G., Cuadrado, Antonio

“…Chronic neuroinflammation is a hallmark of the onset and progression of brain proteinopathies such as Alzheimer disease (AD) and it is suspected to participate…”
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Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1 by Innamorato, Nadia G, Jazwa, Agnieszka, Rojo, Ana I, García, Concepción, Fernández-Ruiz, Javier, Grochot-Przeczek, Anna, Stachurska, Anna, Jozkowicz, Alicja, Dulak, Jozef, Cuadrado, Antonio

“…The transcription factor Nrf2 (NF-E2-related factor 2) and its target gene products, including heme oxygenase-1 (HO-1), elicit an antioxidant response that may…”
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The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation by Innamorato, Nadia G, Rojo, Ana I, Garcia-Yague, Angel J, Yamamoto, Masayuki, de Ceballos, Maria L, Cuadrado, Antonio

“…Because chronic neuroinflammation is a hallmark of neurodegenerative diseases and compromises neuron viability, it is imperative to discover pharmacologic…”
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Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease by Rojo, Ana I., Innamorato, Nadia G., Martín-Moreno, Ana M., De Ceballos, María L., Yamamoto, Masayuki, Cuadrado, Antonio

“…Neural injury leads to inflammation and activation of microglia that in turn may participate in progression of neurodegeneration. The mechanisms involved in…”
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