Search Results - "Roivas, Pekka"

SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers by Lilja, Johanna, Kaivola, Jasmin, Conway, James R. W., Vuorio, Joni, Parkkola, Hanna, Roivas, Pekka, Dibus, Michal, Chastney, Megan R., Varila, Taru, Jacquemet, Guillaume, Peuhu, Emilia, Wang, Emily, Pentikäinen, Ulla, Martinez D. Posada, Itziar, Hamidi, Hellyeh, Najumudeen, Arafath K., Sansom, Owen J., Barsukov, Igor L., Abankwa, Daniel, Vattulainen, Ilpo, Salmi, Marko, Ivaska, Johanna

“…The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS…”
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The Interaction Mechanism of Intrinsically Disordered PP2A Inhibitor Proteins ARPP-16 and ARPP-19 With PP2A by Thapa, Chandan, Roivas, Pekka, Haataja, Tatu, Permi, Perttu, Pentikäinen, Ulla

“…Protein phosphatase 2A (PP2A) activity is critical for maintaining normal physiological cellular functions. PP2A is inhibited by endogenous inhibitor proteins…”
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Interaction mechanism of endogenous PP2A inhibitor protein ENSA with PP2A by Thapa, Chandan, Roivas, Pekka, Haataja, Tatu, Permi, Perttu, Pentikäinen, Ulla

“…The vast diversity of protein phosphatase 2A (PP2A) holoenzyme composition ensures its multifaceted role in the regulation of cellular growth and signal…”
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