Search Results - "Roisman, L"

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke by Tuo, Q-z, Lei, P, Jackman, K A, Li, X-l, Xiong, H, Li, X-l, Liuyang, Z-y, Roisman, L, Zhang, S-t, Ayton, S, Wang, Q, Crouch, P J, Ganio, K, Wang, X-c, Pei, L, Adlard, P A, Lu, Y-m, Cappai, R, Wang, J-z, Liu, R, Bush, A I

“…Functional failure of tau contributes to age-dependent, iron-mediated neurotoxicity, and as iron accumulates in ischemic stroke tissue, we hypothesized that…”
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The micro-environmental cross talk between mast cells and lung cancer cells through cell-to-cell contact by Shemesh, R., Gorzalczany, Y., Sagi-Eisenberg, R., Geva, S., Roisman, L.R.C., Peled, N.

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New Structural and Functional Aspects of the Type I Interferon-Receptor Interaction Revealed by Comprehensive Mutational Analysis of the Binding Interface by Piehler, Jacob, Roisman, Laila C., Schreiber, Gideon

“…Type I interferons bind to two cell surface receptors, ifnar1 and ifnar2, as the first step in the activation of several signal transduction pathways that…”
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Mutational Analysis of the IFNAR1 Binding Site on IFN alpha 2 Reveals the Architecture of a Weak Ligand-Receptor Binding-site by Roisman, L C, Jaitin, DA, Baker, D P, Schreiber, G

“…Type I interferons activate cellular responses by forming a ternary complex with two receptor components, IFNAR1 and IFNAR2. While the binding of the IFNAR2…”
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Structure of the Interferon-Receptor Complex Determined by Distance Constraints from Double-Mutant Cycles and Flexible Docking by Roisman, Laila C., Piehler, Jacob, Trosset, Jean-Yves, Scheraga, Harold A., Schreiber, Gideon

“…The pleiotropic activity of type I interferons has been attributed to the specific interaction of IFN with the cell-surface receptor components ifnar1 and…”
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Optimizing the binding affinity of a carrier protein: a case study on the interaction between soluble ifnar2 and interferon beta by Peleg-Shulman, Tal, Roisman, Laila C, Zupkovitz, Gordin, Schreiber, Gideon

“…Prolonging the circulatory half-life of low mass protein drugs can be achieved either by administration of a pro-drug or through co-injection with a carrier…”
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13PThe micro-environmental cross talk between mast cells and lung cancer cells through cell-to-cell contact by Shemesh, R, Gorzalczany, Y, Sagi-Eisenberg, R, Geva, S, Roisman, L R C, Peled, N

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Perception of bronchial obstruction in asthmatic patients. Relationship with bronchial eosinophilic inflammation and epithelial damage and effect of corticosteroid treatment by Roisman, G L, Peiffer, C, Lacronique, J G, Le Cae, A, Dusser, D J

“…We studied the perception of bronchoconstriction in asthmatic subjects who were randomly treated with inhaled beta 2 agonist given either alone (n = 9) or…”
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Airway responsiveness to bradykinin is related to eosinophilic inflammation in asthma by Roisman, G L, Lacronique, J G, Desmazes-Dufeu, N, Carré, C, Le Cae, A, Dusser, D J

“…We investigated the relationship between airway inflammation and airway responsiveness, as assessed by PD15, to methacholine and to bradykinin in asthmatic…”
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Decreased expression of angiotensin-converting enzyme in the airway epithelium of asthmatic subjects is associated with eosinophil inflammation by Roisman, Gabriel L., Danel, Claire J., Lacronique, Jacques G., Alhenc-Gelas, François, Dusser, Daniel J.

“…Background: Angiotensin-converting enzyme (ACE) is a peptidase involved in the metabolism of several bioactive peptides. It may be involved in the airway…”
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A Molecular Basis for NKT Cell Recognition of CD1d-Self-Antigen by Mallevaey, Thierry, Clarke, Andrew J., Scott-Browne, James P., Young, Mary H., Roisman, Laila C., Pellicci, Daniel G., Patel, Onisha, Vivian, Julian P., Matsuda, Jennifer L., McCluskey, James, Godfrey, Dale I., Marrack, Philippa, Rossjohn, Jamie, Gapin, Laurent

“…The antigen receptor for natural killer T cells (NKT TCR) binds CD1d-restricted microbial and self-lipid antigens, although the molecular basis of self-CD1d…”
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Nedocromil sodium reduces cigarette smoke-induced bronchoconstrictor hyperresponsiveness to substance P in the guinea-pig by Dusser, DJ, Lacroix, H, Desmazes-Dufeu, N, Mordelet-Dambrine, M, Roisman, GL

“…Acute exposure to cigarette smoke provokes airway hyperresponsiveness to substance P and inactivates neutral endopeptidase (NEP). To determine whether…”
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Hydrogen peroxide inhibits lung neutral endopeptidase by Roisman, G L, Dusser, D J

“…Oxidants have been implicated in the pathogenesis of many inflammatory airway diseases. Neutral endopeptidase (also called enkephalinase, EC 3.4.24.11) is a…”
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Community foundations rally 'round a mental health project by Roisman, L

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Bronchial γδ T-lymphocytes and expression of heat shock proteins in mild asthma by FAJAC, I, ROISMAN, G. L, LACRONIQUE, J, POLLA, B. S, DUSSER, D. J

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Inquiring into the Differential Action of Interferons (IFNs): an IFN- alpha 2 Mutant with Enhanced Affinity to IFNAR1 Is Functionally Similar to IFN- beta by Jaitin, Diego A, Roisman, Laila C, Jaks, Eva, Gavutis, Martynas, Piehler, Jacob, Van der Heyden, Jose, Uze, Gilles, Schreiber, Gideon

“…Alpha and beta interferons (IFN- alpha and IFN- beta ) are multifunctional cytokines that exhibit differential activities through a common receptor composed of…”
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Bronchial gamma delta T-lymphocytes and expression of heat shock proteins in mild asthma by Fajac, I, Roisman, GL, Lacronique, J, Polla, BS, Dusser, DJ

“…Heat shock proteins (HSPs), which are important targets for gammadelta T-lymphocytes, are thought to play a role in inflammatory and immune diseases. The…”
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Earned-Secure Attachment Status in Retrospect and Prospect by Roisman, Glenn I., Padrón, Elena, Sroufe, L. Alan, Egeland, Byron

“…Past research with the Berkeley Adult Attachment Interview demonstrates that retrospectively defined earned-secures (who coherently describe negative childhood…”
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Irreversible pulmonary hypertension after correction of tetralogy of Fallot by Roisman, M L, Beller, B M, O'Keefe, J D

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Rare Variants of ATM and Risk for Hodgkin’s Disease and Radiation-associated Breast Cancers by OFFIT, Kenneth, GILAD, Shlomit, PIERCE, Heather Hanson, KAUFF, Noah D, EINAT, Paz, JHANWAR, Suresh, SATAGOPAN, Jaya M, ODDOUX, Carole, ELLIS, Nathan, SKALITER, Rami, YAHALOM, Joachim, PAGLIN, Shoshana, KOLACHANA, Prema, ROISMAN, Laila C, NAFA, Khedoudja, YEUGELEWITZ, Vincent, GONZALES, Maria, ROBSON, Mark, MCDERMOTT, Deborah

“…Purpose: In this study, we first sought to evaluate whetherindividuals heterozygous for ATM mutations may havean increased susceptibility to radiation-induced…”
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