Postmortem Analysis of Vitreous Urea Nitrogen, Creatinine, and Magnesium of Renal and Post-Renal Disease in Cats

Postmortem Analysis of Vitreous Urea Nitrogen, Creatinine, and Magnesium of Renal and Post-Renal Disease in Cats

Analysis of vitreous urea nitrogen (VUN) and creatinine (CREA) has been shown to be a useful indicator of azotemia in human postmortem examinations. Previous studies in cats, dogs, horses, and cattle have shown a good correlation between serum and postmortem ocular fluid for urea and creatinine. The...

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Bibliographic Details
Published in:Toxics (Basel) Vol. 11; no. 8; p. 685
Main Authors: Stern, Adam W, Roig, Daliana, Valerio, Courtney, Denagamage, Thomas
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-08-2023
MDPI
Subjects:
Analysis
Autopsies
Autopsy
cat
Cats
Communication
Creatinine
Development and progression
Diagnosis
Diseases
Electrolytes
Forensic pathology
Horses
Kidney diseases
Magnesium
Necrosis
Nitrogen
postmortem
Renal function
Risk factors
Statistical analysis
Urea
urea nitrogen
Uremia
Urethra
Urinary bladder
vitreous
Vitreous humor
Vitreous humour
United States
United States > US
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Summary:Analysis of vitreous urea nitrogen (VUN) and creatinine (CREA) has been shown to be a useful indicator of azotemia in human postmortem examinations. Previous studies in cats, dogs, horses, and cattle have shown a good correlation between serum and postmortem ocular fluid for urea and creatinine. The aim of this study was to evaluate differences in VUN, CREA, and magnesium (MG) concentrations in vitreous humor collected postmortem from cats that presented with renal or post-renal disease and cats without renal or post-renal disease. Nine cats with renal or post-renal disease and twenty cats without renal or post-renal disease that underwent autopsy were used in this study. Collection of postmortem vitreous humor was performed, and vitreous samples were frozen at −80 °C for a minimum of 24 h prior to analysis using an in-clinic dry chemistry analyzer. Overall, there were statistically significant differences for VUN, CREA, and MG between cats with renal or post-renal disease and cats without renal or post-renal disease. Analysis of vitreous humor from cats suspected to have renal or post-renal disease can provide useful diagnostic information pertaining to renal function and issues in the urethra and urinary bladder. Future studies exploring postmortem vitreous chemistry in cats are warranted.
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ISSN:2305-6304
2305-6304
DOI:10.3390/toxics11080685