Search Results - "Rohrer, SP"

Immunolocalization of Estrogen Receptor β in the Mouse Brain: Comparison with Estrogen Receptor α by Mitra, Sudha Warrier, Hoskin, Elena, Yudkovitz, Joel, Pear, Lisset, Wilkinson, Hilary A, Hayashi, Shinji, Pfaff, Donald W, Ogawa, Sonoko, Rohrer, Susan P, Schaeffer, James M, McEwen, Bruce S, Alves, Stephen E

“…Estrogen receptor α (ERα) and ERβ are members of the steroid nuclear receptor family that modulate gene transcription in an estrogen-dependent manner. ER mRNA…”
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Distinct effects of the antiestrogen Faslodex on the stability of estrogen receptors-alpha and -beta in the breast cancer cell line MCF-7 by Peekhaus, NT, Chang, T, Hayes, EC, Wilkinson, HA, Mitra, SW, Schaeffer, JM, Rohrer, SP

“…The effects of estrogen receptor (ER) ligands on the stability and transcriptional activity of ERbeta in the breast cancer cell lines MCF-7 and HeLa were…”
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17 Beta-estradiol-induced antidepressant-like effect in the forced swim test is absent in estrogen receptor-beta knockout (BERKO) mice by Rocha, Beatriz A, Fleischer, Rebecca, Schaeffer, James M, Rohrer, Susan P, Hickey, Gerry J

“…The decrease in levels of estrogens (ER) that occurs in menopause has been correlated with depressive disorders, probably due to ER direct and/or indirect…”
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6H-Benzo[c]chromen-6-one derivatives as selective ERβ agonists by Sun, Wanying, Cama, Lovji D., Birzin, Elizabeth T., Warrier, Sudha, Locco, Louis, Mosley, Ralph, Hammond, Milton L., Rohrer, Susan P.

“…A series of 6H-benzo[c]chromen-6-one and 6H-benzo[c]chromene derivatives were prepared. Many of the analogs were found to be potent and selective ERβ agonists…”
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Identification of somatostatin receptors controlling growth hormone and thyrotropin secretion in the chicken using receptor subtype-specific agonists by Geris, KL, de Groef, B, Rohrer, SP, Geelissen, S, Kuhn, ER, Darras, VM

“…Somatostatin (SRIH) functions as an endocrine mediator in processes such as growth, immune resistance and reproduction. Five SRIH receptors (sstr1-5) have been…”
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Estrogen receptor-β regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe by Gundlah, Chrisana, Alves, Stephen E., Clark, Janet A., Pai, Lee-Yuh, Schaeffer, James M., Rohrer, Susan P.

“…Distinct expression patterns of estrogen receptor (ER)-α and ER-β are displayed in the murine central nervous system. ER-β is the predominant form of the…”
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Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry by Rohrer, Susan P., Birzin, Elizabeth T., Mosley, Ralph T., Berk, Scott C., Hutchins, Steven M., Shen, Dong-Ming, Xiong, Yusheng, Hayes, Edward C., Parmar, Rupa M., Foor, Forrest, Mitra, Sudha W., Degrado, Sylvia J., Shu, Min, Klopp, John M., Cai, Sheng-Jian, Blake, Allan, Wanda W. S. Chan, Pasternak, Alex, Yang, Lihu, Patchett, Arthur A., Smith, Roy G., Chapman, Kevin T., Schaeffer, James M.

“…Nonpeptide agonists of each of the five somatostatin receptors were identified in combinatorial libraries constructed on the basis of molecular modeling of…”
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Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor α Modulators by Kim, Seongkon, Wu, Jane Y, Birzin, Elizabeth T, Frisch, Katalin, Chan, Wanda, Pai, Lee-Yuh, Yang, Yi Tien, Mosley, Ralph T, Fitzgerald, Paula M. D, Sharma, Nandini, Dahllund, Johanna, Thorsell, Ann-Gerd, DiNinno, Frank, Rohrer, Susan P, Schaeffer, James M, Hammond, Milton L

“…The discovery and synthesis of dihydrobenzoxathiins as potent, ERα subtype selective ligands are described. The most active analogue, 4-D, was found to be…”
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Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus by Clark, Janet A., Pai, Lee-Yuh, Flick, Rosemarie Beth, Rohrer, Susan P.

“…Recently a novel tryptophan hydroxylase isoform (TPH2) was identified and shown to be highly expressed in the central nervous system (CNS). Hormonal effects on…”
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Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers by Blizzard, Timothy A., DiNinno, Frank, Morgan, Jerry D., Chen, Helen Y., Wu, Jane Y., Kim, Seongkon, Chan, Wanda, Birzin, Elizabeth T., Yang, Yi Tien, Pai, Lee-Yuh, Fitzgerald, Paula M.D., Sharma, Nandini, Li, Ying, Zhang, Zhoupeng, Hayes, Edward C., DaSilva, Carolyn A., Tang, Wei, Rohrer, Susan P., Schaeffer, James M., Hammond, Milton L.

“…A series of benzoxathiin SERAMs was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity,…”
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The discovery of tetrahydrofluorenones as a new class of estrogen receptor β-subtype selective ligands by Wilkening, R.R., Ratcliffe, R.W., Tynebor, E.C., Wildonger, K.J., Fried, A.K., Hammond, M.L., Mosley, R.T., Fitzgerald, P.M.D., Sharma, N., McKeever, B.M., Nilsson, S., Carlquist, M., Thorsell, A., Locco, L., Katz, R., Frisch, K., Birzin, E.T., Wilkinson, H.A., Mitra, S., Cai, S., Hayes, E.C., Schaeffer, J.M., Rohrer, S.P.

“…Synthesis and derivatization of a series of substituted tetrahydrofluorenone analogs giving potent, ERβ subtype-selective ligands are described. Synthesis and…”
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Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice by Viollet, C., Vaillend, C., Videau, C., Bluet-Pajot, M. T., Ungerer, A., L'héritier, A., Kopp, C., Potier, B., Billard, J. -M., Schaeffer, J., Smith, R. G., Rohrer, S. P., Wilkinson, H., Zheng, H., Epelbaum, J.

“…Somatostatin (SRIF) controls many physiological and pathological processes in the central nervous system but the respective roles of the five receptor isotypes…”
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Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity by Chen, Helen Y., Dykstra, Kevin D., Birzin, Elizabeth T., Frisch, Katalin, Chan, Wanda, Yang, Yi T., Mosley, Ralph T., DiNinno, Frank, Rohrer, Susan P., Schaeffer, James M., Hammond, Milton L.

“…A class of flavanoids exhibiting a high degree of selectivity for ERα over ERβ has been discovered. The most active analogue 6 was found to be 66-fold…”
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Effects of Heterocyclic Aromatic Substituents on Binding Affinities at Two Distinct Sites of Somatostatin Receptors. Correlation with the Electrostatic Potential of the Substituents by Prasad, Vidya, Birzin, Elizabeth T, McVaugh, Cheryl T, van Rijn, Rachel D, Rohrer, Susan P, Chicchi, Gary, Underwood, Dennis J, Thornton, Edward R, Smith, Amos B, Hirschmann, Ralph

“…In our continuing program exploring glucose-based peptidomimetics of somatostatin (SRIF-14), we sought to improve the water solubility of our glycosides. This…”
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Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs by Tan, Qiang, Blizzard, Timothy A., Morgan, Jerry D., Birzin, Elizabeth T., Chan, Wanda, Yang, Yi Tien, Pai, Lee-Yuh, Hayes, Edward C., DaSilva, Carolyn A., Warrier, Sudha, Yudkovitz, Joel, Wilkinson, Hilary A., Sharma, Nandini, Fitzgerald, Paula M.D., Li, Susan, Colwell, Lawrence, Fisher, John E., Adamski, Sharon, Reszka, Alfred A., Kimmel, Donald, DiNinno, Frank, Rohrer, Susan P., Freedman, Leonard P., Schaeffer, James M., Hammond, Milton L.

“…Chromanes I were discovered as SERAMs (Selective Estrogen Receptor Alpha Modulators) with the potential for the treatment of osteoporosis and cancer. The…”
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Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs by Chen, Helen Y., Kim, Seongkon, Wu, Jane Y., Birzin, Elizabeth T., Chan, Wanda, Yang, Yi Tien, Dahllund, Johanna, DiNinno, Frank, Rohrer, Susan P., Schaeffer, James M., Hammond, Milton L.

“…A class of dihydrobenzoxathiins 1 exhibiting a high degree of selectivity for ERα over ERβ has been discovered. The SAR of dihydrobenzoxathiins with…”
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Synthesis and Biological Activities of Potent Peptidomimetics Selective for Somatostatin Receptor Subtype 2 by Yang, Lihu, Berk, Scott C., Rohrer, Susan P., Mosley, Ralph T., Guo, Liangqin, Underwood, Dennis J., Arison, Byron H., Birzin, Elizabeth T., Hayes, Edward C., Mitra, Sudha W., Parmar, Rupa M., Cheng, Kang, Wu, Tsuei-Ju, Butler, Bridgette S., Foor, Forrest, Pasternak, Alexander, Pan, Yanping, Silva, Maria, Freidinger, Roger M., Smith, Roy G., Chapman, Kevin, Schaeffer, James M., Patchett, Arthur A.

“…A series of nonpeptide somatostatin agonists which bind selectively and with high affinity to somatostatin receptor subtype 2 (sst2) have been synthesized. One…”
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Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans by Liu, Jian, Birzin, Elizabeth T., Chan, Wanda, Yang, Yi Tien, Pai, Lee-Yuh, DaSilva, Carolyn, Hayes, Edward C., Mosley, Ralph T., DiNinno, Frank, Rohrer, Susan P., Schaeffer, James M., Hammond, Milton L.

“…The isochroman and isothiochroman compounds were synthesized as potent estrogen receptor ligands. The ring oxygen and sulfur analogs of lasofoxifene, 1a and…”
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Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain by Blizzard, Timothy A., DiNinno, Frank, Chen, Helen Y., Kim, Seongkon, Wu, Jane Y., Chan, Wanda, Birzin, Elizabeth T., Yang, Yi Tien, Pai, Lee-Yuh, Hayes, Edward C., DaSilva, Carolyn A., Rohrer, Susan P., Schaeffer, James M., Hammond, Milton L.

“…An optimized side chain for dihydrobenzoxathiin SERAMs was discovered and attached to four dihydrobenzoxathiin platforms. The novel SERAMs show exceptional…”
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Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains by Blizzard, Timothy A, DiNinno, Frank, Morgan, Jerry D, Chen, Helen Y, Wu, Jane Y, Gude, Candido, Kim, Seongkon, Chan, Wanda, Birzin, Elizabeth T, Tien Yang, Yi, Pai, Lee-Yuh, Zhang, Zhoupeng, Hayes, Edward C, DaSilva, Carolyn A, Tang, Wei, Rohrer, Susan P, Schaeffer, James M, Hammond, Milton L

“…A series of benzoxathiin SERAMs was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in…”
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