Search Results - "Roher, Alex"

Morphological and pathological evolution of the brain microcirculation in aging and Alzheimer's disease by Hunter, Jesse M, Kwan, Jason, Malek-Ahmadi, Michael, Maarouf, Chera L, Kokjohn, Tyler A, Belden, Christine, Sabbagh, Marwan N, Beach, Thomas G, Roher, Alex E

“…Key pathological hallmarks of Alzheimer's disease (AD), including amyloid plaques, cerebral amyloid angiopathy (CAA) and neurofibrillary tangles do not…”
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Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program by Beach, Thomas G., Adler, Charles H., Sue, Lucia I., Serrano, Geidy, Shill, Holly A., Walker, Douglas G., Lue, LihFen, Roher, Alex E., Dugger, Brittany N., Maarouf, Chera, Birdsill, Alex C., Intorcia, Anthony, Saxon-Labelle, Megan, Pullen, Joel, Scroggins, Alexander, Filon, Jessica, Scott, Sarah, Hoffman, Brittany, Garcia, Angelica, Caviness, John N., Hentz, Joseph G., Driver-Dunckley, Erika, Jacobson, Sandra A., Davis, Kathryn J., Belden, Christine M., Long, Kathy E., Malek-Ahmadi, Michael, Powell, Jessica J., Gale, Lisa D., Nicholson, Lisa R., Caselli, Richard J., Woodruff, Bryan K., Rapscak, Steven Z., Ahern, Geoffrey L., Shi, Jiong, Burke, Anna D., Reiman, Eric M., Sabbagh, Marwan N.

“…The Brain and Body Donation Program (BBDP) at Banner Sun Health Research Institute (http://www.brainandbodydonationprogram.org) started in 1987 with brain‐only…”
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APP/Aβ structural diversity and Alzheimer's disease pathogenesis by Roher, Alex E., Kokjohn, Tyler A., Clarke, Steven G., Sierks, Michael R., Maarouf, Chera L., Serrano, Geidy E., Sabbagh, Marwan S., Beach, Thomas G.

“…The amyloid cascade hypothesis of Alzheimer's disease (AD) proposes amyloid- β (Aβ) is a chief pathological element of dementia. AD therapies have targeted…”
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Characterizing Apolipoprotein E ε4 Carriers and Noncarriers With the Clinical Diagnosis of Mild to Moderate Alzheimer Dementia and Minimal β-Amyloid Peptide Plaques by Monsell, Sarah E, Kukull, Walter A, Roher, Alex E, Maarouf, Chera L, Serrano, Geidy, Beach, Thomas G, Caselli, Richard J, Montine, Thomas J, Reiman, Eric M

“…β-Amyloid peptide (Aβ) plaques are a cardinal neuropathologic feature of Alzheimer disease (AD), yet more than one-third of apolipoprotein E ε4 (APOE4)…”
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Amyloid precursor protein transgenic mouse models and Alzheimer's disease: Understanding the paradigms, limitations, and contributions by Kokjohn, Tyler A, Roher, Alex E

“…Abstract Transgenic (Tg) mice that overexpress mutant familial Alzheimer's disease (AD) amyloid precursor protein (APP) genes have contributed to an…”
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Cerebral blood flow in Alzheimer's disease by Roher, Alex E, Debbins, Josef P, Malek-Ahmadi, Michael, Chen, Kewei, Pipe, James G, Maze, Sharmeen, Belden, Christine, Maarouf, Chera L, Thiyyagura, Pradeep, Mo, Hua, Hunter, Jesse M, Kokjohn, Tyler A, Walker, Douglas G, Kruchowsky, Jane C, Belohlavek, Marek, Sabbagh, Marwan N, Beach, Thomas G

“…Alzheimer's disease (AD) dementia is a consequence of heterogeneous and complex interactions of age-related neurodegeneration and vascular-associated…”
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Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging by Maarouf, Chera L, Daugs, Ian D, Kokjohn, Tyler A, Walker, Douglas G, Hunter, Jesse M, Kruchowsky, Jane C, Woltjer, Randy, Kaye, Jeffrey, Castaño, Eduardo M, Sabbagh, Marwan N, Beach, Thomas G, Roher, Alex E

“…The amyloid cascade hypothesis provides an economical mechanistic explanation for Alzheimer's disease (AD) dementia and correlated neuropathology. However,…”
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Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE ε4 allele, the major late-onset Alzheimer's susceptibility gene by Valla, Jon, Yaari, Roy, Wolf, Andrew B, Kusne, Yael, Beach, Thomas G, Roher, Alex E, Corneveaux, Jason J, Huentelman, Matthew J, Caselli, Richard J, Reiman, Eric M

“…In vivo PET imaging studies of young-adult carriers of the apolipoprotein E ε4 allele (APOEε4), the major Alzheimer's disease (AD) susceptibility gene, have…”
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Antibody responses, amyloid-beta peptide remnants and clinical effects of AN-1792 immunization in patients with AD in an interrupted trial by Kokjohn, Tyler A, Roher, Alex E

“…Post mortem examinations of AN-1792-vaccinated humans revealed this therapy produced focal senile plaque disruption. Despite the dispersal of substantial…”
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Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities by Pistollato, Francesca, Ohayon, Elan L, Lam, Ann, Langley, Gillian R, Novak, Thomas J, Pamies, David, Perry, George, Trushina, Eugenia, Williams, Robin S B, Roher, Alex E, Hartung, Thomas, Harnad, Stevan, Barnard, Neal, Morris, Martha Clare, Lai, Mei-Chun, Merkley, Ryan, Chandrasekera, P Charukeshi

“…Much of Alzheimer disease (AD) research has been traditionally based on the use of animals, which have been extensively applied in an effort to both improve…”
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Familial Presenilin Mutations and Sporadic Alzheimer's Disease Pathology: Is the Assumption of Biochemical Equivalence Justified? by Roher, Alex E, Maarouf, Chera L, Kokjohn, Tyler A

“…Studies of presenilin (PSEN) gene mutations producing early onset Alzheimer's disease (AD) have helped elucidate the pathogenic mechanisms of dementia and…”
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Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy by Roher, Alex E, Cribbs, David H, Kim, Ronald C, Maarouf, Chera L, Whiteside, Charisse M, Kokjohn, Tyler A, Daugs, Ian D, Head, Elizabeth, Liebsack, Carolyn, Serrano, Geidy, Belden, Christine, Sabbagh, Marwan N, Beach, Thomas G

“…The characteristic neuropathological changes associated with Alzheimer's disease (AD) and other lines of evidence support the amyloid cascade hypothesis…”
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The Presence of Select Tau Species in Human Peripheral Tissues and Their Relation to Alzheimer's Disease by Dugger, Brittany N, Whiteside, Charisse M, Maarouf, Chera L, Walker, Douglas G, Beach, Thomas G, Sue, Lucia I, Garcia, Angelica, Dunckley, Travis, Meechoovet, Bessie, Reiman, Eric M, Roher, Alex E

“…Tau becomes excessively phosphorylated in Alzheimer's disease (AD) and is widely studied within the brain. Further examination of the extent and types of tau…”
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Biochemical assessment of precuneus and posterior cingulate gyrus in the context of brain aging and Alzheimer's disease by Maarouf, Chera L, Kokjohn, Tyler A, Walker, Douglas G, Whiteside, Charisse M, Kalback, Walter M, Whetzel, Alexis, Sue, Lucia I, Serrano, Geidy, Jacobson, Sandra A, Sabbagh, Marwan N, Reiman, Eric M, Beach, Thomas G, Roher, Alex E

“…Defining the biochemical alterations that occur in the brain during "normal" aging is an important part of understanding the pathophysiology of…”
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Transcranial Doppler ultrasound blood flow velocity and pulsatility index as systemic indicators for Alzheimer’s disease by Roher, Alex E, Garami, Zsolt, Tyas, Suzanne L, Maarouf, Chera L, Kokjohn, Tyler A, Belohlavek, Marek, Vedders, Linda J, Connor, Donald, Sabbagh, Marwan N, Beach, Thomas G, Emmerling, Mark R

“…Abstract Background Multiple lines of evidence suggest that cardiovascular co-morbidities hasten the onset of Alzheimer’s disease (AD) or accelerate its…”
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Intracranial atherosclerosis as a contributing factor to Alzheimer’s disease dementia by Roher, Alex E, Tyas, Suzanne L, Maarouf, Chera L, Daugs, Ian D, Kokjohn, Tyler A, Emmerling, Mark R, Garami, Zsolt, Belohlavek, Marek, Sabbagh, Marwan N, Sue, Lucia I, Beach, Thomas G

“…Abstract Background A substantial body of evidence collected from epidemiologic, correlative, and experimental studies strongly associates atherosclerotic…”
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Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease by Roher, Alex E, Esh, Chera L, Kokjohn, Tyler A, Castaño, Eduardo M, Van Vickle, Gregory D, Kalback, Walter M, Patton, R. Lyle, Luehrs, Dean C, Daugs, Ian D, Kuo, Yu-Min, Emmerling, Mark R, Soares, Holly, Quinn, Joseph F, Kaye, Jeffrey, Connor, Donald J, Silverberg, Nina B, Adler, Charles H, Seward, James D, Beach, Thomas G, Sabbagh, Marwan N

“…Abstract Background We evaluated the amounts of amyloid beta (Aβ)) peptides in the central nervous system (CNS) and in reservoirs outside the CNS and their…”
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Circle of Willis atherosclerosis: association with Alzheimer's disease, neuritic plaques and neurofibrillary tangles by Beach, Thomas G, Wilson, Jeffrey R, Sue, Lucia I, Newell, Amanda, Poston, Marissa, Cisneros, Raquel, Pandya, Yoga, Esh, Chera, Connor, Donald J, Sabbagh, Marwan, Walker, Douglas G, Roher, Alex E

“…The role of intracranial atherosclerosis in Alzheimer's disease (AD) has been a subject of debate since the first decade of the last century. The initial…”
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Circle of Willis Atherosclerosis Is a Risk Factor for Sporadic Alzheimer’s Disease by Roher, Alex E, Esh, Chera, Kokjohn, Tyler A, Kalback, Walter, Luehrs, Dean C, Seward, James D, Sue, Lucia I, Beach, Thomas G

“…OBJECTIVES—We conducted a quantitative investigation of brain arterial atherosclerotic damage and its relationship to sporadic Alzheimer’s disease (AD)…”
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Comparative proteomics of cerebrospinal fluid in neuropathologically-confirmed Alzheimer's disease and non-demented elderly subjects by Castaño, Eduardo M., Roher, Alex E., Esh, Chera L., Kokjohn, Tyler A., Beach, Thomas

“…Objectives: Diagnostic tests able to reveal Alzheimer's disease (AD) in living patients before cognitive ability is destroyed are urgently needed. Such tests…”
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