Search Results - "Rohani, Nazanin"

Microenvironment-triggered multimodal precision diagnostics by Hao, Liangliang, Rohani, Nazanin, Zhao, Renee T., Pulver, Emilia M., Mak, Howard, Kelada, Olivia J., Ko, Henry, Fleming, Heather E., Gertler, Frank B., Bhatia, Sangeeta N.

“…Therapeutic outcomes in oncology may be aided by precision diagnostics that offer early detection, localization and the opportunity to monitor response to…”
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Variable combinations of specific ephrin ligand/Eph receptor pairs control embryonic tissue separation by Rohani, Nazanin, Parmeggiani, Andrea, Winklbauer, Rudolf, Fagotto, François

“…Ephrins and Eph receptors are involved in the establishment of vertebrate tissue boundaries. The complexity of the system is puzzling, however in many…”
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A Molecular Base for Cell Sorting at Embryonic Boundaries: Contact Inhibition of Cadherin Adhesion by Ephrin/Eph-Dependent Contractility by Fagotto, François, Rohani, Nazanin, Touret, Anne-Sophie, Li, Rui

“…The mechanism responsible for subdividing the embryo into individual tissues is a fundamental, yet still poorly understood, question in developmental biology…”
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Measuring learning gain during a one-day introductory bronchoscopy course by Colt, Henri G., Davoudi, Mohsen, Murgu, Septimiu, Zamanian Rohani, Nazanin

“…Background Rigorous assessment of medical knowledge and technical skill inspires learning, reinforces confidence, and reassures the public. Identifying…”
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Structure-based dual affinity optimization of a SARS-CoV-1/2 cross-reactive single-domain antibody by Sulea, Traian, Baardsnes, Jason, Stuible, Matthew, Rohani, Nazanin, Tran, Anh, Parat, Marie, Cepero Donates, Yuneivy, Duchesne, Mélanie, Plante, Pierre, Kour, Guneet, Durocher, Yves

“…The SARS coronavirus 2 (SARS-CoV-2) spike (S) protein binding to the human ACE2 receptor is the molecular event that initiates viral entry into host cells and…”
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Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment by Sulea, Traian, Rohani, Nazanin, Baardsnes, Jason, Corbeil, Christopher R, Deprez, Christophe, Cepero-Donates, Yuneivy, Robert, Alma, Schrag, Joseph D, Parat, Marie, Duchesne, Mélanie, Jaramillo, Maria L, Purisima, Enrico O, Zwaagstra, John C

“…Recent development of monoclonal antibodies as mainstream anticancer agents demands further optimization of their safety for use in humans. Potent targeting…”
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EpCAM Controls Actomyosin Contractility and Cell Adhesion by Direct Inhibition of PKC by Maghzal, Nadim, Kayali, Hulya A., Rohani, Nazanin, Kajava, Andrey V., Fagotto, François

“…Epithelial cell adhesion molecule (EpCAM) is a cell-surface protein highly expressed in embryonic tissues and in malignant carcinomas. We report that EpCAM…”
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Tuning the immune response: sulfated archaeal glycolipid archaeosomes as an effective vaccine adjuvant for induction of humoral and cell-mediated immunity towards the SARS-CoV-2 Omicron variant of concern by Renner, Tyler M, Akache, Bassel, Stuible, Matthew, Rohani, Nazanin, Cepero-Donates, Yuneivy, Deschatelets, Lise, Dudani, Renu, Harrison, Blair A, Baardsnes, Jason, Koyuturk, Izel, Hill, Jennifer J, Hemraz, Usha D, Régnier, Sophie, Lenferink, Anne E G, Durocher, Yves, McCluskie, Michael J

“…Liposomes composed of sulfated lactosyl archaeol (SLA) have been shown to be a safe and effective vaccine adjuvant with a multitude of antigens in preclinical…”
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Immunogenicity of SARS-CoV-2 spike antigens derived from Beta & Delta variants of concern by Akache, Bassel, Renner, Tyler M., Stuible, Matthew, Rohani, Nazanin, Cepero-Donates, Yuneivy, Deschatelets, Lise, Dudani, Renu, Harrison, Blair A., Gervais, Christian, Hill, Jennifer J., Hemraz, Usha D., Lam, Edmond, Régnier, Sophie, Lenferink, Anne E. G., Durocher, Yves, McCluskie, Michael J.

“…Using our strongly immunogenic SmT1 SARS-CoV-2 spike antigen platform, we developed antigens based on the Beta & Delta variants of concern (VOC). These…”
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EphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment by Rohani, Nazanin, Canty, Laura, Luu, Olivia, Fagotto, François, Winklbauer, Rudolf

“…The primordial organization of the metazoan body is achieved during gastrulation by the establishment of the germ layers. Adhesion differences between…”
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Comparative effectiveness of low- and high-fidelity bronchoscopy simulation for training in conventional transbronchial needle aspiration and user preferences by Davoudi, Mohsen, Wahidi, Momen M, Zamanian Rohani, Nazanin, Colt, Henri G

“…Conventional transbronchial needle aspiration (TBNA) can be learned using high-fidelity virtual-reality platforms and low-fidelity models comprised of molded…”
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Use of competency-based metrics to determine effectiveness of a postgraduate thoracoscopy course by Colt, Henri G, Davoudi, Mohsen, Quadrelli, Silvia, Zamanian Rohani, Nazanin

“…Despite the paradigm shift from process to competency-based education, no study has explored how competency-based metrics might be used to assess short-term…”
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Ephrin-Eph signaling in embryonic tissue separation by Fagotto, Francois, Winklbauer, Rudolf, Rohani, Nazanin

“…The physical separation of the embryonic regions that give rise to the tissues and organs of multicellular organisms is a fundamental aspect of morphogenesis…”
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Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes by Rohani, Nazanin, Hao, Liangliang, Alexis, Maria S, Joughin, Brian A, Krismer, Konstantin, Moufarrej, Mira N, Soltis, Anthony R, Lauffenburger, Douglas A, Yaffe, Michael B, Burge, Christopher B, Bhatia, Sangeeta N, Gertler, Frank B

“…Acidosis is a fundamental feature of the tumor microenvironment, which directly regulates tumor cell invasion by affecting immune cell function, clonal cell…”
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Abstract B041: Mimicking tumor acidic and hypoxic microenvironment in vitro towards generation of more predictive screening platform for solid tumors by Larijani, Nazanin Rohani, Huot, Marielle, Lenferink, Anne, Raynal, Noël R.

“…Abstract The drug discovery process in oncology relies mainly on screening and preclinical validation platforms that use human cancer cells that are grown in…”
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Abstract PO-049: Exploiting tumor acidic microenvironment for improved therapeutics by Larijani, Nazanin Rohani, Sulea, Traian, Ghahroudi, Mehdi Arbabi, Roc, Beatrice Paul, Gosselin, Mylene, Sheff, Joey, Zwaagstra, John C., Lenferink, Anne E.G.

“…Abstract The tumor acidic microenvironment is a fundamental characteristic of solid tumors which distinguishes the tumor from adjacent normal tissues. This…”
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Variable Combinations of Specific Ephrin Ligand/Eph Receptor Pairs Control Embryonic Tissue Separation: e1001955 by Rohani, Nazanin, Parmeggiani, Andrea, Winklbauer, Rudolf, Fagotto, François

“…Ephrins and Eph receptors are involved in the establishment of vertebrate tissue boundaries. The complexity of the system is puzzling, however in many…”
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Characterization of the expression of the pro-metastatic Mena(INV) isoform during breast tumor progression by Oudin, Madeleine J, Hughes, Shannon K, Rohani, Nazanin, Moufarrej, Mira N, Jones, Joan G, Condeelis, John S, Lauffenburger, Douglas A, Gertler, Frank B

“…Several functionally distinct isoforms of the actin regulatory Mena are produced by alternative splicing during tumor progression. Forced expression of the…”
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Characterization of the expression of the pro-metastatic Mena^sup INV^ isoform during breast tumor progression by Oudin, Madeleine J, Hughes, Shannon K, Rohani, Nazanin, Moufarrej, Mira N, Jones, Joan G, Condeelis, John S, Lauffenburger, Douglas A, Gertler, Frank B

“…Several functionally distinct isoforms of the actin regulatory Mena are produced by alternative splicing during tumor progression. Forced expression of the…”
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Characterization of the expression of the pro-metastatic MenaINV isoform during breast tumor progression by Oudin, Madeleine J., Hughes, Shannon K., Rohani, Nazanin, Moufarrej, Mira N., Jones, Joan G., Condeelis, John S., Lauffenburger, Douglas A., Gertler, Frank B.

“…Several functionally distinct isoforms of the actin regulatory Mena are produced by alternative splicing during tumor progression. Forced expression of the…”
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