Search Results - "Roh, K."
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Single-Dose Treatment with Rapamycin Preserves Post-Ischemic Cardiac Function through Attenuation of Fibrosis and Inflammation in Diabetic Rabbit
Published in International journal of molecular sciences (19-05-2023)“…Robust activation of mTOR (mammalian target of rapamycin) signaling in diabetes exacerbates myocardial injury following lethal ischemia due to accelerated…”
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Evaluation of anti-acne properties of phloretin in vitro and in vivo
Published in International journal of cosmetic science (01-02-2016)“…Synopsis Objective This study aimed to investigate the anti‐acne properties of phloretin in vitro and in vivo. Methods Anti‐microbial activity against…”
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Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cells
Published in Cell proliferation (01-12-2009)“…Objectives: Histone deacetylase (HDAC) is an important therapeutic target in cancer. Two of the main anticancer mechanisms of HDAC inhibitors are induction of…”
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Epigenetic Therapy Using Belinostat for Patients With Unresectable Hepatocellular Carcinoma: A Multicenter Phase I/II Study With Biomarker and Pharmacokinetic Analysis of Tumors From Patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group
Published in Journal of clinical oncology (20-09-2012)“…Epigenetic aberrations have been reported in hepatocellular carcinoma (HCC). In this study of patients with unresectable HCC and chronic liver disease,…”
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Effects of celecoxib on hematoma and edema volumes in primary intracerebral hemorrhage: a multicenter randomized controlled trial
Published in European journal of neurology (01-08-2013)“…Background and purpose We investigated the effect of celecoxib, a selective inhibitor of cyclo‐oxygenase 2, in patients with intracerebral hemorrhage (ICH)…”
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Decreased number and function of endothelial progenitor cells in patients with migraine
Published in Neurology (22-04-2008)“…Migraine carries an increased risk for cardiovascular and cerebrovascular diseases that cannot be explained by traditional cardiovascular risk factors. The…”
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Short-term biocompatibility of biphasic nanocolloids with potential use as anisotropic imaging probes
Published in Biomaterials (01-05-2007)“…Abstract Advances in nanotechnology, in particular the development of novel types of nanoparticles, will result in advanced tools for biomedical research and…”
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Alternative energy efficient membrane bioreactor using reciprocating submerged membrane
Published in Water science and technology (01-01-2014)“…A novel membrane bioreactor (MBR) pilot system, using membrane reciprocation instead of air scouring, was operated at constant high flux and daily fluctuating…”
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Accelerated maximum likelihood parameter estimation for stochastic biochemical systems
Published in BMC bioinformatics (01-05-2012)“…A prerequisite for the mechanistic simulation of a biochemical system is detailed knowledge of its kinetic parameters. Despite recent experimental advances,…”
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Changing ischaemic lesion patterns in adult moyamoya disease
Published in Journal of neurology, neurosurgery and psychiatry (01-01-2009)“…Objectives: Ischaemic stroke is a frequent manifestation in patients with adult moyamoya disease (MMD), but the relationship between the lesion pattern and…”
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Integrated Analysis of lncRNA-miRNA-mRNA Regulatory Network in Rapamycin-Induced Cardioprotection against Ischemia/Reperfusion Injury in Diabetic Rabbits
Published in Cells (Basel, Switzerland) (01-12-2023)“…The inhibition of mammalian target of rapamycin (mTOR) with rapamycin (RAPA) provides protection against myocardial ischemia/reperfusion (I/R) injury in…”
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Utility of digital subtraction angiography‐based collateral evaluation in medically treated acute symptomatic basilar artery stenosis
Published in European journal of neurology (01-09-2017)“…Background and purpose Although a stroke from atherosclerosis in the basilar artery (BA) often presents with mild initial stroke severity, it has heterogeneous…”
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A Randomized Phase II/III Study of Dalotuzumab in Combination With Cetuximab and Irinotecan in Chemorefractory, KRAS Wild-Type, Metastatic Colorectal Cancer
Published in JNCI : Journal of the National Cancer Institute (01-12-2015)“…Insulin-like growth factor type 1 receptor (IGF-1R) mediates resistance to epidermal growth factor receptor (EGFR) inhibition and may represent a therapeutic…”
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Survival benefit of combined curative resection of the stomach (D2 resection) and liver in gastric cancer patients with liver metastases
Published in Annals of oncology (01-06-2008)“…The benefit of surgical resection of liver metastases from gastric cancer has not been well established. The aim of this study was to evaluate the rationale…”
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Characteristic features of unruptured intracranial aneurysms: predictive risk factors for aneurysm rupture
Published in Journal of neurology, neurosurgery and psychiatry (01-05-2010)“…Background and purposeThe purpose of this study was to identify the risk factors predisposing to aneurysm rupture and to provide a reliable estimation for…”
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Differential Regulation of mTOR Complexes with miR-302a Attenuates Myocardial Reperfusion Injury in Diabetes
Published in iScience (18-12-2020)“…Persistent activation of mTOR (mammalian target of rapamycin) in diabetes increases the vulnerability of the heart to ischemia/reperfusion (I/R) injury. We…”
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Preclinical model of type 1 diabetes and myocardial ischemia/reperfusion injury in conscious rabbits—demonstration of cardioprotection with rapamycin
Published in STAR protocols (17-09-2021)“…We developed a preclinical model of myocardial ischemia/reperfusion (I/R) injury in conscious diabetic rabbits to identify an early pharmacological…”
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Reduced circulating angiogenic cells in Alzheimer disease
Published in Neurology (26-05-2009)“…Neurovascular dysfunction and senescent endothelium contribute to the progression of Alzheimer disease (AD). Circulating angiogenic cells (CACs), such as…”
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Association of the ABCB1 gene polymorphisms 2677G>T/A and 3435C>T with clinical outcomes of paclitaxel monotherapy in metastatic breast cancer patients
Published in Annals of oncology (01-02-2009)“…Background: ABCB1 is responsible for multidrug resistance, the principal mechanism by which many cancers develop resistance to chemotherapeutic drugs. There is…”
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