Search Results - "Roh, Eun Joo"

AKF-D52, a Synthetic Phenoxypyrimidine-Urea Derivative, Triggers Extrinsic/Intrinsic Apoptosis and Cytoprotective Autophagy in Human Non-Small Cell Lung Cancer Cells by Gil, Hyo-Sun, Lee, Jeong-Hun, Farag, Ahmed K., Hassan, Ahmed H. E., Chung, Kyung-Sook, Choi, Jung-Hye, Roh, Eun-Joo, Lee, Kyung-Tae

“…Previously, we discovered that 1-(3,5-dimethoxyphenyl)-3-(4-(3-methoxyphenoxy)-2-((4-morpholinophenyl)amino)pyrimidin-5-yl)urea (AKF-D52), a synthetic…”
Get full text

MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice by Hechler, Béatrice, Nonne, Christelle, Roh, Eun Joo, Cattaneo, Marco, Cazenave, Jean-Pierre, Lanza, François, Jacobson, Kenneth A, Gachet, Christian

“…The platelet P2Y(1) ADP receptor is an attractive target for new antiplatelet drugs. However, because of the lack of strong and stable antagonists, only a few…”
Get more information

Death‐associated protein kinase (DAPK) family modulators: Current and future therapeutic outcomes by Farag, Ahmed Karam, Roh, Eun Joo

“…Serine/threonine kinases (STKs) represent the majority of discovered kinases to date even though a few Food and Drug Administration approved STKs inhibitors…”
Get full text

Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments by Antar, Samar A., Ashour, Nada A., Sharaky, Marwa, Khattab, Muhammad, Ashour, Naira A., Zaid, Roaa T., Roh, Eun Joo, Elkamhawy, Ahmed, Al-Karmalawy, Ahmed A.

“…Nowadays, diabetes mellitus has emerged as a significant global public health concern with a remarkable increase in its prevalence. This review article focuses…”
Get full text

P2Y1 Antagonists:  Combining Receptor-Based Modeling and QSAR for a Quantitative Prediction of the Biological Activity Based on Consensus Scoring by Costanzi, Stefano, Tikhonova, Irina G, Ohno, Michihiro, Roh, Eun Joo, Joshi, Bhalchandra V, Colson, Anny-Odile, Houston, Dayle, Maddileti, Savitri, Harden, T. Kendall, Jacobson, Kenneth A

“…P2Y1 is an ADP-activated G protein-coupled receptor (GPCR). Its antagonists impede platelet aggregation in vivo and are potential antithrombotic agents…”
Get full text

Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R by Kang, Seokmin, Hong, Jinpyo, Lee, Jung Moo, Moon, Hyo Eun, Jeon, Borami, Choi, Jungil, Yoon, Nal Ae, Paek, Sun Ha, Roh, Eun Joo, Lee, C Justin, Kang, Sang Soo

“…Calcium (Ca ) signaling is an important signaling process, implicated in cancer cell proliferation and motility of the deadly glioblastomas that aggressively…”
Get full text

Design, Synthesis and Biological Evaluation of 1,3,5-Triazine Derivatives Targeting hA1 and hA3 Adenosine Receptor by Park, Sujin, Ahn, Yujin, Kim, Yongchan, Roh, Eun Joo, Lee, Yoonji, Han, Chaebin, Yoo, Hee Min, Yu, Jinha

“…Adenosine mediates various physiological activities in the body. Adenosine receptors (ARs) are widely expressed in tumors and the tumor microenvironment (TME),…”
Get full text

Discovery of N-benzylbenzamide-based allosteric inhibitors of Aurora kinase A by Lee, Hyomin, Kim, Euijung, Hwang, Narae, Yoo, Jesik, Nam, Yunju, Hwang, Injeoung, Park, Jin-Gyeong, Park, Sang-Eun, Chung, Kyung-Sook, Won Chung, Hwan, Song, Chiman, Ji, Mi-Jung, Park, Hyun-Mee, Lee, In-Kyun, Lee, Kyung-Tae, Joo Roh, Eun, Hur, Wooyoung

“…[Display omitted] •Novel AurkA allosteric inhibitors of N-benzylbenzamide backbone were designed and synthesized.•The most potent analogue 6h (AurkA…”
Get full text

Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights by Al-Sanea, Mohammad M., Elkamhawy, Ahmed, Paik, Sora, Lee, Kyeong, El Kerdawy, Ahmed M., Syed Nasir Abbas, Bukhari, Joo Roh, Eun, Eldehna, Wagdy M., Elshemy, Heba A.H., Bakr, Rania B, Ali Farahat, Ibrahim, Alzarea, Abdulaziz I., Alzarea, Sami I., Alharbi, Khalid S., Abdelgawad, Mohamed A.

“…Three series of 4-anilinoquinoline derivatives bearing a sulfonamide moiety (5a-d, 9a-d and 11a-d) were designed and synthesized as potential novel dual Aurora…”
Get full text

Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity by Mourad, Mai A. E., Abo Elmaaty, Ayman, Zaki, Islam, Mourad, Ahmed A. E., Hofni, Amal, Khodir, Ahmed E., Aboubakr, Esam M., Elkamhawy, Ahmed, Roh, Eun Joo, Al-Karmalawy, Ahmed A.

“…Topoisomerases II are ubiquitous enzymes with significant genotoxic effects in many critical DNA processes. Additionally, epidermal growth factor receptor…”
Get full text

Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening by Elkamhawy, Ahmed, Ammar, Usama M., Paik, Sora, Abdellattif, Magda H., Elsherbeny, Mohamed H., Lee, Kyeong, Roh, Eun Joo

“…Recently, multitargeted drugs are considered a potential approach in treating cancer. In this study, twelve in-house indole-based derivatives were preliminary…”
Get full text

Reprofiling of pyrimidine-based DAPK1/CSF1R dual inhibitors: identification of 2,5-diamino-4-pyrimidinol derivatives as novel potential anticancer lead compounds by Farag, Ahmed K., Hassan, Ahmed H. E., Ahn, Byung Sun, Park, Ki Duk, Roh, Eun Joo

“…Hybridization of reported weakly active antiproliferative hit 5-amino-4-pyrimidinol derivative with 2-anilino-4-phenoxypyrimidines suggests a series of…”
Get full text

EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor by Elkamhawy, Ahmed, Hassan, Ahmed H.E., Paik, Sora, Sup Lee, Yong, Lee, Hwi-Ho, Shin, Ji-Sun, Lee, Kyung-Tae, Roh, Eun Joo

“…[Display omitted] •Compound 4d is an anti-inflammatory EGFR inhibitor.•Compound 4d inhibits LPS-induced NO, IL-1β, IL-6 and TNF-α production.•Compound 4d…”
Get full text

Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B by Elkamhawy, Ahmed, Paik, Sora, Kim, Hyeon Jeong, Park, Jong-Hyun, Londhe, Ashwini M., Lee, Kyeong, Pae, Ae Nim, Park, Ki Duk, Roh, Eun Joo

“…Herein, two new series of N-substituted indole-based analogues were rationally designed, synthesized via microwave heating technology, and evaluated as…”
Get full text

Synthesis and structure–activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer’s disease by Lee, Yun Suk, Kim, Hee, Kim, Young-Ho, Roh, Eun Joo, Han, Hogyu, Shin, Kye Jung

“…A series of thiazole derivatives were designed, and prepared to develop RAGE antagonist for the treatment of Alzheimer’s disease (AD). SAR studies were…”
Get full text

Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants by Lee, Elliot H., Park, Jung-eun, Gotina, Lizaveta, Han, Young-Eun, Viswanath, Ambily Nath Indu, Yoo, Seonguk, Moon, Bongjin, Hwang, Jin-Young, Park, Woo Kyu, Cho, Yoonjeong, Song, Chiman, Min, Sun-Joon, Hwang, Eun Mi, Lee, Hyunbeom, Pae, Ae Nim, Roh, Eun Joo, Oh, Soo-Jin

“…TREK-1 (TWIK-related potassium channel-1) is a subunit of the two-pore domain potassium (K2p) channel and is widely expressed in the brain. TREK-1 knockout…”
Get full text

Identification of Novel Aryl Carboxamide Derivatives as Death-Associated Protein Kinase 1 (DAPK1) Inhibitors with Anti-Proliferative Activities: Design, Synthesis, In Vitro, and In Silico Biological Studies by Elkamhawy, Ahmed, Paik, Sora, Ali, Eslam M. H, Hassan, Ahmed H. E, Kang, So Jin, Lee, Kyeong, Roh, Eun Joo

“…Death-associated protein kinase 1 (DAPK1) is a serine/threonine protein kinase involved in diverse fundamental cellular processes such as apoptosis and…”
Get full text

Caffeine-Mediated Inhibition of Calcium Release Channel Inositol 1,4,5-Trisphosphate Receptor Subtype 3 Blocks Glioblastoma Invasion and Extends Survival by SANG SOO KANG, HAN, Kyung-Seok, SEUNG HYUN YOO, CHUN KEE CHUNG, PARK, Sung-Hye, SUN HA PAEK, EUN JOO ROH, SUNG JOONG LEE, PARK, Jae-Yong, TRAYNELIS, Stephen F, LEE, C. Justin, BO MI KU, YEON KYUNG LEE, HONG, Jinpyo, HYE YOUNG SHIN, ALMONTE, Antoine G, DONG HO WOO, BRAT, Daniel J, EUN MI HWANG

“…Calcium signaling is important in many signaling processes in cancer cell proliferation and motility including in deadly glioblastomas of the brain that…”
Get full text

Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress by Elkamhawy, Ahmed, Woo, Jiyu, Gouda, Noha A., Kim, Jushin, Nada, Hossam, Roh, Eun Joo, Park, Ki Duk, Cho, Jungsook, Lee, Kyeong

“…Monoamine oxidase B (MAO-B) metabolizes dopamine and plays an important role in oxidative stress by altering the redox state of neuronal and glial cells. MAO-B…”
Get full text

Design, Synthesis, In Vitro, and In Silico Studies of New N5-Substituted-pyrazolo[3,4-d]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors by Zaki, Waheed A., El-Sayed, Selwan M., Alswah, Mohamed, El-Morsy, Ahmed, Bayoumi, Ashraf H., Mayhoub, Abrahman S., Moustafa, Walaa H., Awaji, Aeshah A., Roh, Eun Joo, Hassan, Ahmed H.E., Mahmoud, Kazem

“…CDK2 is a key player in cell cycle processes. It has a crucial role in the progression of various cancers. Hepatocellular carcinoma (HCC) and colorectal cancer…”
Get full text