SEND-PD in Parkinsonian Syndromes: Results of a Monocentric Cross-Sectional Study

Neuropsychiatric symptoms in particular impair health-related quality of life (QoL) of patients with Parkinson's disease and atypical Parkinsonian syndromes. For this reason, various scales have been developed for detection of neuropsychiatric symptoms, such as the Scale for evaluation of neuro...

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Published in:	Neuropsychiatric disease and treatment Vol. 20; pp. 1849 - 1859
Main Authors:	Veith Sanches, Linda, Greten, Stephan, Doll-Lee, Johanna, Rogozinski, Sophia Marie, Heine, Johanne, Krey, Lea, Ulaganathan, Sarana, Jensen, Ida, Höllerhage, Matthias, Sani, Sam Sadeghi, Höglinger, Günter U, Wegner, Florian, Klietz, Martin
Format:	Journal Article
Language:	English
Published:	New Zealand Dove Medical Press Limited 01-10-2024 Dove Dove Medical Press
Subjects:	Analysis Care and treatment Complications and side effects Diagnosis Mental illness neuropsychiatric symptoms Original Research Parkinson's disease parkinsonian syndromes Prevalence studies (Epidemiology) Prevention Psychological manifestations of general diseases Risk factors send-pd Germany neuropsychiatric symptoms SEND-PD Parkinsonian syndromes
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Summary:	Neuropsychiatric symptoms in particular impair health-related quality of life (QoL) of patients with Parkinson's disease and atypical Parkinsonian syndromes. For this reason, various scales have been developed for detection of neuropsychiatric symptoms, such as the Scale for evaluation of neuropsychiatric disorders in Parkinson's disease (SEND-PD). First, the objective of this study was to explore the interrelation between the SEND-PD and clinical parameters in patients with Parkinson's disease and thus confirm its validity. In addition, the applicability in a well-defined cohort of patients with atypical Parkinsonian syndromes was investigated for the very first time. A clinically well-defined cohort of 122 patients with Parkinson's disease (PD), 55 patients with Progressive Supranuclear Palsy (PSP) and 33 patients with Multiple System Atrophy (MSA) were analyzed. First, the SEND-PD was correlated with established disease-specific scores in patients with PD. Next, the results of the SEND-PD were compared between the different Parkinsonian syndromes. The SEND-PD showed a strong significant correlation with several scores, especially the UPDRS I (Rho = 0.655) and GDS-15 (Rho = 0.645). Depressive burden was significantly higher in MSA patients in comparison to the PD patient cohort (PD, 3.8 ± 3.3; MSA, 5.45 ± 3.87), while PSP patients showed significantly less psychotic (PD 1.6 ± 2.1; PSP 0.6 ± 0.9) and impulse control disorders (PD 0.3 ± 1.0; PSP 0.02 ± 0.1). The SEND-PD is a useful, brief and highly applicable screening tool for neuropsychiatric symptoms in PD, but not in atypical Parkinsonism, as their unique neuropsychiatric symptom composition is not fully captured.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work
ISSN:	1176-6328 1178-2021 1178-2021
DOI:	10.2147/NDT.S474584