Search Results - "Rognoni, Lorenz"

Dynamic force sensing of filamin revealed in single-molecule experiments by Rognoni, Lorenz, Stigler, Johannes, Pelz, Benjamin, Ylänne, Jari, Rief, Matthias

“…Mechanical forces are important signals for cell response and development, but detailed molecular mechanisms of force sensing are largely unexplored. The…”
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SlyD Accelerates trans-to-cis Prolyl Isomerization in a Mechanosignaling Protein under Load by Sengupta, Abhigyan, Rognoni, Lorenz E, Merkel, Ulrich, Žoldák, Gabriel, Rief, Matthias

“…Prolyl isomerization is recognized as one of the key regulatory mechanisms, which plays a crucial role in cell signaling, ion channel gating, phage virus…”
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Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin by Rognoni, Lorenz, Möst, Tobias, Žoldák, Gabriel, Rief, Matthias

“…Proline switches, controlled by cis–trans isomerization, have emerged as a particularly effective regulatory mechanism in a wide range of biological processes…”
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Automated image analysis of NSCLC biopsies to predict response to anti-PD-L1 therapy by Althammer, Sonja, Tan, Tze Heng, Spitzmüller, Andreas, Rognoni, Lorenz, Wiestler, Tobias, Herz, Thomas, Widmaier, Moritz, Rebelatto, Marlon C, Kaplon, Helene, Damotte, Diane, Alifano, Marco, Hammond, Scott A, Dieu-Nosjean, Marie-Caroline, Ranade, Koustubh, Schmidt, Guenter, Higgs, Brandon W, Steele, Keith E

“…Immune checkpoint therapies (ICTs) targeting the programmed cell death-1 (PD1)/programmed cell death ligand-1 (PD-L1) pathway have improved outcomes for…”
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Measuring multiple parameters of CD8+ tumor-infiltrating lymphocytes in human cancers by image analysis by Steele, Keith E, Tan, Tze Heng, Korn, René, Dacosta, Karma, Brown, Charles, Kuziora, Michael, Zimmermann, Johannes, Laffin, Brian, Widmaier, Moritz, Rognoni, Lorenz, Cardenes, Ruben, Schneider, Katrin, Boutrin, Anmarie, Martin, Philip, Zha, Jiping, Wiestler, Tobias

“…Immuno-oncology and cancer immunotherapies are areas of intense research. The numbers and locations of CD8+ tumor-infiltrating lymphocytes (TILs) are important…”
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Abstract 4932: UltiAnalyzer.AI: An automatic and robust AI-Driven tool for the quantification of multiplex immunofluorescence whole slide images by Cardenes, Ruben, Wood, Douglas, Schulze, Martin, Lee, Je, Rognoni, Lorenz

“…Introduction: Whole slide multiplexed immunofluorescence (mIF) facilitates in-depth study of the tumor microenvironment with multi-channel images resulting in…”
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Abstract 4933: A workflow for cloud-based AI development of multiplex IF image analysis using the OMERO Plus platform by Cardenes, Ruben, Diel, Erin, Wood, Douglas, Lee, Je, Vasaturo, Angela, Schulze, Martin, Rognoni, Lorenz

“…Background: The advancement of AI in digital pathology is essential for analyzing image data containing billions of cells. This is true for digital pathology…”
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Filamin's Force Sensing Mechanism Revealed by Optical Tweezers by Rognoni, Lorenz E., Pentikäinen, Ulla, Ylänne, Jari, Rief, Matthias

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39 A multi-modal analysis approach leveraging multiplexed spatial phenotyping and multi-omics analysis to better understand the prognostic value of tertiary lymphoid structures in NSCLC by Berthe, Julie, Sridhar, Sriram, Segerer, Felix, Testori, Marco, Saraiya, Megha, Rognoni, Lorenz, Hessel, Harald, Andoni, Alma, Shumilov, Anatoliy, Spitzmüller, Andreas, Heininen-Brown, Mari, Blando, Jorge, Ng, Felicia, Jones, Emma, Willis, Sophie, Surace, Michael, Ven, Rieneke van de, Gruijl, Tanja de, Angell, Helen

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Novel Deep Learning Approach to Derive Cytokeratin Expression and Epithelium Segmentation from DAPI by Segerer, Felix Jakob, Nekolla, Katharina, Rognoni, Lorenz, Kapil, Ansh, Schick, Markus, Angell, Helen, Schmidt, Günter

“…Generative Adversarial Networks (GANs) are state of the art for image synthesis. Here, we present dapi2ck, a novel GAN-based approach to synthesize cytokeratin…”
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