Search Results - "Rogler, Leslie E."

MicroRNA‐23b cluster microRNAs regulate transforming growth factor‐beta/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads by Rogler, Charles E., LeVoci, Lauretta, Ader, Tammy, Massimi, Aldo, Tchaikovskaya, Tatyana, Norel, Raquel, Rogler, Leslie E.

“…Transforming growth factor‐beta / bone morphogenetic protein (TGFβ/BMP) signaling has a gradient of effects on cell fate choice in the fetal mouse liver. The…”
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Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB by Connolly, Erin C, Van Doorslaer, Koenraad, Rogler, Leslie E, Rogler, Charles E

“…Metastasis is a multistep process that involves the deregulation of oncogenes and tumor suppressors beyond changes required for primary tumor formation. RHOB…”
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Elevated Expression of the miR-17–92 Polycistron and miR-21 in Hepadnavirus-Associated Hepatocellular Carcinoma Contributes to the Malignant Phenotype by Connolly, Erin, Melegari, Margherita, Landgraf, Pablo, Tchaikovskaya, Tatyana, Tennant, Bud C, Slagle, Betty L, Rogler, Leslie E, Zavolan, Mihaela, Tuschl, Thomas, Rogler, Charles E

“…Alterations in microRNA (miRNA) expression in both human and animal models have been linked to many forms of cancer. Such miRNAs, which act directly as…”
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Identification of hepatocytic and bile ductular cell lineages and candidate stem cells in bipolar ductular reactions in cirrhotic human liver by Zhou, Hongchao, Rogler, Leslie E., Teperman, Lewis, Morgan, Glyn, Rogler, Charles E.

“…Hepatocyte function and regeneration are severely compromised in severe liver disease, and a common sequela is cirrhosis. Structural changes caused by…”
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Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage–hair hypoplasia by Rogler, Leslie E., Kosmyna, Brian, Moskowitz, David, Bebawee, Remon, Rahimzadeh, Joseph, Kutchko, Katrina, Laederach, Alain, Notarangelo, Luigi D., Giliani, Silvia, Bouhassira, Eric, Frenette, Paul, Roy-Chowdhury, Jayanta, Rogler, Charles E.

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New cell surface markers for murine fetal hepatic stem cells identified through high density complementary DNA microarrays by Nierhoff, Dirk, Levoci, Lauretta, Schulte, Sigrid, Goeser, Tobias, Rogler, Leslie E., Shafritz, David A.

“…Isolation of hepatic stem cells from the adult liver (AL) has not yet been achieved due to the lack of specific cell surface markers. To identify new surface…”
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cDNA microarray analysis of HBV transgenic mouse liver identifies genes in lipid biosynthetic and growth control pathways affected by HBV by Hajjou, Mustapha, Norel, Raquel, Carver, Robert, Marion, Patricia, Cullen, John, Rogler, Leslie E., Rogler, Charles E.

“…Hepatitis B virus (HBV) transgenic mice that replicate HBV in the liver generally do not exhibit gross liver pathology, while maintaining a high level (107 or…”
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Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage-hair hypoplasia by Rogler, Leslie E, Kosmyna, Brian, Moskowitz, David, Bebawee, Remon, Rahimzadeh, Joseph, Kutchko, Katrina, Laederach, Alain, Notarangelo, Luigi D, Giliani, Silvia, Bouhassira, Eric, Frenette, Paul, Roy-Chowdhury, Jayanta, Rogler, Charles E

“…Post-transcriptional processing of some long non-coding RNAs (lncRNAs) reveals that they are a source of miRNAs. We show that the 268-nt non-coding RNA…”
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Triple Staining Including FOXA2 Identifies Stem Cell Lineages Undergoing Hepatic and Biliary Differentiation in Cirrhotic Human Liver by Rogler, Charles E., Bebawee, Remon, Matarlo, Joe, Locker, Joseph, Pattamanuch, Nicole, Gupta, Sanjeev, Rogler, Leslie E.

“…Recent investigations have reported many markers associated with human liver stem/progenitor cells, “oval cells,” and identified “niches” in diseased livers…”
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Knockdown of miR-23, miR-27, and miR-24 Alters Fetal Liver Development and Blocks Fibrosis in Mice by Rogler, Charles E., Matarlo, Joe S., Kosmyna, Brian, Fulop, Daniel, Rogler, Leslie E.

“…MicroRNAs (miRNAs) regulate cell fate selection and cellular differentiation. miRNAs of the miR23b polycistron (miR-23b, miR-27b, and miR-24) target components…”
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Experimental Model for Successful Liver Cell Therapy by Lenti TTR-YapERT2 Transduced Hepatocytes with Tamoxifen Control of Yap Subcellular Location by Yovchev, Mladen, Jaber, Fadi L., Lu, Zhonglei, Patel, Shachi, Locker, Joseph, Rogler, Leslie E., Murray, John W., Sudol, Marius, Dabeva, Mariana D., Zhu, Liang, Shafritz, David A.

“…Liver repopulation by transplanted hepatocytes has not been achieved previously in a normal liver microenvironment. Here we report that adult rat hepatocytes…”
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Genes and Pathways Promoting Long‐Term Liver Repopulation by Ex Vivo hYAP‐ERT2 Transduced Hepatocytes and Treatment of Jaundice in Gunn Rats by Peterson, Esther A., Polgar, Zsuzsanna, Devakanmalai, Gnanapackiam S., Li, Yanfeng, Jaber, Fadi L., Zhang, Wei, Wang, Xia, Iqbal, Niloy J., Murray, John W., Roy‐Chowdhury, Namita, Quispe‐Tintaya, Wilber, Maslov, Alexander Y., Tchaikovskaya, Tatyana L., Sharma, Yogeshwar, Rogler, Leslie E., Gupta, Sanjeev, Zhu, Liang, Roy‐Chowdhury, Jayanta, Shafritz, David A.

“…Hepatocyte transplantation is an attractive alternative to liver transplantation. Thus far, however, extensive liver repopulation by adult hepatocytes has…”
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Clonal, cultured, murine fetal liver hepatoblasts maintain liver specification in chimeric mice by Rogler, Charles E., Zhou, Hong Chou, LeVoci, Lauretta, Rogler, Leslie E.

“…Recent studies have shown a pluripotential nature of stem cells that were previously thought to be committed to specific lineages. HBC‐3 cells are a clonal…”
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Selective Alterations in Organ Sizes in Mice with a Targeted Disruption of the Insulin-Like Growth Factor Binding Protein-2 Gene by Wood, Teresa L, Rogler, Leslie E, Czick, Maureen E, Schuller, Alwin G.P, Pintar, John E

“…Insulin-like growth factor binding protein 2 (IGFBP-2) is one member of the family of IGF binding proteins believed to have both endocrine functions elicited…”
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Selective bipotential differentiation of mouse embryonic hepatoblasts in vitro by Rogler, LE

“…A line of hepatic endoderm cells, hepatoblast cell line 3 (HBC-3), was derived from the liver diverticulum of the mouse on day 9.5 of gestation by culture on a…”
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RNA expression microarrays (REMs), a high-throughput method to measure differences in gene expression in diverse biological samples by Rogler, Charles E., Tchaikovskaya, Tatyana, Norel, Raquel, Massimi, Aldo, Plescia, Christopher, Rubashevsky, Eugeny, Siebert, Paul, Rogler, Leslie E.

“…We have developed RNA expression microarrays (REMs), in which each spot on a glass support is composed of a population of cDNAs synthesized from a cell or…”
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Genomic expression analysis implicates Wnt signaling pathway and extracellular matrix alterations in hepatic specification and differentiation of murine hepatic stem cells by Plescia, Christopher P., Rogler, Charles E., Rogler, Leslie E.

“…HBC-3 hepatic stem cells maintained in the undifferentiated state can be induced to differentiate along the hepatocyte lineage in response to DMSO (Rogler,…”
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Reactivation of the maternally imprinted IGF2 allele in TGFα induced hepatocellular carcinomas in mice by HARRIS, T. M, ROGLER, L. E, ROGLER, C. E

“…The Insulin like growth factor 2 (IGF2) gene is expressed in several types of tumors in humans and mice and has been implicated as an important growth factor…”
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271 Embryonic hepatoblasts share patterns of gene expression with other stem cell populations by Ader, Tammy, Norel, Rachel, Rogler, Charles E., Rogler, Leslie E.

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Transcriptional profiling implicates TGFβ/BMP and Notch signaling pathways in ductular differentiation of fetal murine hepatoblasts by Ader, Tammy, Norel, Raquel, Levoci, Lauretta, Rogler, Leslie E.

“…Bile duct morphogenesis involves sequential induction of biliary specific gene expression, bilayer generation, cell proliferation, remodeling and apoptosis…”
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