Search Results - "Rogers, Kelly L."

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis by McArthur, Kate, Whitehead, Lachlan W, Heddleston, John M, Li, Lucy, Padman, Benjamin S, Oorschot, Viola, Geoghegan, Niall D, Chappaz, Stephane, Davidson, Sophia, San Chin, Hui, Lane, Rachael M, Dramicanin, Marija, Saunders, Tahnee L, Sugiana, Canny, Lessene, Romina, Osellame, Laura D, Chew, Teng-Leong, Dewson, Grant, Lazarou, Michael, Ramm, Georg, Lessene, Guillaume, Ryan, Michael T, Rogers, Kelly L, van Delft, Mark F, Kile, Benjamin T

“…Mitochondrial apoptosis is mediated by BAK and BAX, two proteins that induce mitochondrial outer membrane permeabilization, leading to cytochrome c release and…”
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MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis by Samson, Andre L., Zhang, Ying, Geoghegan, Niall D., Gavin, Xavier J., Davies, Katherine A., Mlodzianoski, Michael J., Whitehead, Lachlan W., Frank, Daniel, Garnish, Sarah E., Fitzgibbon, Cheree, Hempel, Anne, Young, Samuel N., Jacobsen, Annette V., Cawthorne, Wayne, Petrie, Emma J., Faux, Maree C., Shield-Artin, Kristy, Lalaoui, Najoua, Hildebrand, Joanne M., Silke, John, Rogers, Kelly L., Lessene, Guillaume, Hawkins, Edwin D., Murphy, James M.

“…Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is…”
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Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes by Volz, Jennifer C., Yap, Alan, Sisquella, Xavier, Thompson, Jenn K., Lim, Nicholas T.Y., Whitehead, Lachlan W., Chen, Lin, Lampe, Marko, Tham, Wai-Hong, Wilson, Danny, Nebl, Thomas, Marapana, Danushka, Triglia, Tony, Wong, Wilson, Rogers, Kelly L., Cowman, Alan F.

“…Plasmodium falciparum parasites in the merozoite stage invade human erythrocytes and cause malaria. Invasion requires multiple interactions between merozoite…”
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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands by Duckworth, Brigette C., Lafouresse, Fanny, Wimmer, Verena C., Broomfield, Benjamin J., Dalit, Lennard, Alexandre, Yannick O., Sheikh, Amania A., Qin, Raymond Z., Alvarado, Carolina, Mielke, Lisa A., Pellegrini, Marc, Mueller, Scott N., Boudier, Thomas, Rogers, Kelly L., Groom, Joanna R.

“…T cells dynamically interact with multiple, distinct cellular subsets to determine effector and memory differentiation. Here, we developed a platform to…”
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Monosodium Urate Crystals Generate Nuclease-Resistant Neutrophil Extracellular Traps via a Distinct Molecular Pathway by Chatfield, Simon M, Grebe, Kathrin, Whitehead, Lachlan W, Rogers, Kelly L, Nebl, Thomas, Murphy, James M, Wicks, Ian P

“…Neutrophil extracellular traps (NETs) and the cell death associated with it (NETosis) have been implicated in numerous diseases. Mechanistic studies of NETosis…”
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A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells by Samson, André L., Fitzgibbon, Cheree, Patel, Komal M., Hildebrand, Joanne M., Whitehead, Lachlan W., Rimes, Joel S., Jacobsen, Annette V., Horne, Christopher R., Gavin, Xavier J., Young, Samuel N., Rogers, Kelly L., Hawkins, Edwin D., Murphy, James M.

“…Necroptosis is a lytic, inflammatory cell death pathway that is dysregulated in many human pathologies. The pathway is executed by a core machinery comprising…”
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Deficiency in coatomer complex I causes aberrant activation of STING signalling by Steiner, Annemarie, Hrovat-Schaale, Katja, Prigione, Ignazia, Yu, Chien-Hsiung, Laohamonthonkul, Pawat, Harapas, Cassandra R., Low, Ronnie Ren Jie, De Nardo, Dominic, Dagley, Laura F., Mlodzianoski, Michael J., Rogers, Kelly L., Zillinger, Thomas, Hartmann, Gunther, Gantier, Michael P., Gattorno, Marco, Geyer, Matthias, Volpi, Stefano, Davidson, Sophia, Masters, Seth L.

“…Coatomer complex I (COPI) mediates retrograde vesicular trafficking from Golgi to the endoplasmic reticulum (ER) and within Golgi compartments. Deficiency in…”
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4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation by Geoghegan, Niall D., Evelyn, Cindy, Whitehead, Lachlan W., Pasternak, Michal, McDonald, Phoebe, Triglia, Tony, Marapana, Danushka S., Kempe, Daryan, Thompson, Jennifer K., Mlodzianoski, Michael J., Healer, Julie, Biro, Maté, Cowman, Alan F., Rogers, Kelly L.

“…Host membrane remodeling is indispensable for viruses, bacteria, and parasites, to subvert the membrane barrier and obtain entry into cells. The malaria…”
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Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte by Riglar, David T, Richard, Dave, Wilson, Danny W, Boyle, Michelle J, Dekiwadia, Chaitali, Turnbull, Lynne, Angrisano, Fiona, Marapana, Danushka S, Rogers, Kelly L, Whitchurch, Cynthia B, Beeson, James G, Cowman, Alan F, Ralph, Stuart A, Baum, Jake

“…Erythrocyte invasion by the merozoite is an obligatory stage in Plasmodium parasite infection and essential to malaria disease progression. Attempts to study…”
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Transcriptional modification of host cells harboring Toxoplasma gondii bradyzoites prevents IFN gamma-mediated cell death by Seizova, Simona, Ruparel, Ushma, Garnham, Alexandra L., Bader, Stefanie M., Uboldi, Alessandro D., Coffey, Michael J., Whitehead, Lachlan W., Rogers, Kelly L., Tonkin, Christopher J.

“…Toxoplasma gondii develops a latent infection in the muscle and central nervous system that acts as a reservoir for acute-stage reactivation in vulnerable…”
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Neutrophil-Delivered Myeloperoxidase Dampens the Hydrogen Peroxide Burst after Tissue Wounding in Zebrafish by Pase, Luke, Layton, Judith E., Wittmann, Christine, Ellett, Felix, Nowell, Cameron J., Reyes-Aldasoro, Constantino Carlos, Varma, Sony, Rogers, Kelly L., Hall, Chris J., Keightley, M. Cristina, Crosier, Philip S., Grabher, Clemens, Heath, Joan K., Renshaw, Stephen A., Lieschke, Graham J.

“…Prompt neutrophil arrival is critical for host defense immediately after injury [1–3]. Following wounding, a hydrogen peroxide (H2O2) burst generated in…”
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Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission by Lopaticki, Sash, McConville, Robyn, John, Alan, Geoghegan, Niall, Mohamed, Shihab Deen, Verzier, Lisa, Steel, Ryan W. J., Evelyn, Cindy, O’Neill, Matthew T., Soler, Niccolay Madiedo, Scott, Nichollas E., Rogers, Kelly L., Goddard-Borger, Ethan D., Boddey, Justin A.

“…Tryptophan C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that Plasmodium falciparum expresses a…”
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Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1 by Dans, Madeline G., Boulet, Coralie, Watson, Gabrielle M., Nguyen, William, Dziekan, Jerzy M., Evelyn, Cindy, Reaksudsan, Kitsanapong, Mehra, Somya, Razook, Zahra, Geoghegan, Niall D., Mlodzianoski, Michael J., Goodman, Christopher Dean, Ling, Dawson B., Jonsdottir, Thorey K., Tong, Joshua, Famodimu, Mufuliat Toyin, Kristan, Mojca, Pollard, Harry, Stewart, Lindsay B., Brandner-Garrod, Luke, Sutherland, Colin J., Delves, Michael J., McFadden, Geoffrey I., Barry, Alyssa E., Crabb, Brendan S., de Koning-Ward, Tania F., Rogers, Kelly L., Cowman, Alan F., Tham, Wai-Hong, Sleebs, Brad E., Gilson, Paul R.

“…With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833…”
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Author Correction: Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1 by Dans, Madeline G., Boulet, Coralie, Watson, Gabrielle M., Nguyen, William, Dziekan, Jerzy M., Evelyn, Cindy, Reaksudsan, Kitsanapong, Mehra, Somya, Razook, Zahra, Geoghegan, Niall D., Mlodzianoski, Michael J., Goodman, Christopher Dean, Ling, Dawson B., Jonsdottir, Thorey K., Tong, Joshua, Famodimu, Mufuliat Toyin, Kristan, Mojca, Pollard, Harry, Stewart, Lindsay B., Brandner-Garrod, Luke, Sutherland, Colin J., Delves, Michael J., McFadden, Geoffrey I., Barry, Alyssa E., Crabb, Brendan S., de Koning-Ward, Tania F., Rogers, Kelly L., Cowman, Alan F., Tham, Wai-Hong, Sleebs, Brad E., Gilson, Paul R.

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Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics by Dans, Madeline G, Piirainen, Henni, Nguyen, William, Khurana, Sachin, Mehra, Somya, Razook, Zahra, Geoghegan, Niall D, Dawson, Aurelie T, Das, Sujaan, Parkyn Schneider, Molly, Jonsdottir, Thorey K, Gabriela, Mikha, Gancheva, Maria R, Tonkin, Christopher J, Mollard, Vanessa, Goodman, Christopher Dean, McFadden, Geoffrey I, Wilson, Danny W, Rogers, Kelly L, Barry, Alyssa E, Crabb, Brendan S, de Koning-Ward, Tania F, Sleebs, Brad E, Kursula, Inari, Gilson, Paul R

“…With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently…”
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Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice by Yang, Annie S.P., O’Neill, Matthew T., Jennison, Charlie, Lopaticki, Sash, Allison, Cody C., Armistead, Jennifer S., Erickson, Sara M., Rogers, Kelly L., Ellisdon, Andrew M., Whisstock, James C., Tweedell, Rebecca E., Dinglasan, Rhoel R., Douglas, Donna N., Kneteman, Norman M., Boddey, Justin A.

“…Malaria sporozoites are deposited into the skin by mosquitoes and infect hepatocytes. The molecular basis of how Plasmodium falciparum sporozoites migrate…”
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In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions by Atkin-Smith, Georgia K., Santavanond, Jascinta P., Light, Amanda, Rimes, Joel S., Samson, Andre L., Er, Jeremy, Liu, Joy, Johnson, Darryl N., Le Page, Mélanie, Rajasekhar, Pradeep, Yip, Raymond K. H., Geoghegan, Niall D., Rogers, Kelly L., Chang, Catherine, Bryant, Vanessa L., Margetts, Mai, Keightley, M. Cristina, Kilpatrick, Trevor J., Binder, Michele D., Tran, Sharon, Lee, Erinna F., Fairlie, Walter D., Ozkocak, Dilara C., Wei, Andrew H., Hawkins, Edwin D., Poon, Ivan K. H.

“…Endothelial cells are integral components of all vasculature within complex organisms. As they line the blood vessel wall, endothelial cells are constantly…”
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Publisher Correction: Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission by Lopaticki, Sash, McConville, Robyn, John, Alan, Geoghegan, Niall, Mohamed, Shihab Deen, Verzier, Lisa, Steel, Ryan W. J., Evelyn, Cindy, O’Neill, Matthew T., Soler, Niccolay Madiedo, Scott, Nichollas E., Rogers, Kelly L., Goddard-Borger, Ethan D., Boddey, Justin A.

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A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo by Potts, Kathryn S., Sargeant, Tobias J., Markham, John F., Shi, Wei, Biben, Christine, Josefsson, Emma C., Whitehead, Lachlan W., Rogers, Kelly L., Liakhovitskaia, Anna, Smyth, Gordon K., Kile, Benjamin T., Medvinsky, Alexander, Alexander, Warren S., Hilton, Douglas J., Taoudi, Samir

“…In this study, we test the assumption that the hematopoietic progenitor/colony-forming cells of the embryonic yolk sac (YS), which are endowed with…”
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