Search Results - "Rogers, Chris A"

Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial by Chakravarthy, Usha, Prof, Harding, Simon P, Prof, Rogers, Chris A, PhD, Downes, Susan M, MD, Lotery, Andrew J, Prof, Culliford, Lucy A, PhD, Reeves, Barnaby C, Prof

“…Summary Background Bevacizumab has been suggested to have similar effectiveness to ranibizumab for treatment of neovascular age-related macular degeneration…”
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Increased Mortality, Postoperative Morbidity, and Cost After Red Blood Cell Transfusion in Patients Having Cardiac Surgery by MURPHY, Gavin J, REEVES, Barnaby C, ROGERS, Chris A, RIZVI, Syed I. A, CULLIFORD, Lucy, ANGELINI, Gianni D

“…Red blood cell transfusion can both benefit and harm. To inform decisions about transfusion, we aimed to quantify associations of transfusion with clinical…”
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Malperfusion rather than merely timing of operative repair determines early and late outcome in type A aortic dissection by Narayan, Pradeep, FRCS[CTh], Rogers, Chris A., PhD, Benedetto, Umberto, MD, Caputo, Massimo, MD, Angelini, Gianni D., FRCS, Bryan, Alan J., FRCS[CTh]

“…Abstract Background Although generally better outcomes are reported in patients undergoing early repair of type A aortic dissection, patients who survive the…”
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Impact of video-assisted thoracoscopic lobectomy versus open lobectomy for lung cancer on recovery assessed using self-reported physical function: VIOLET RCT by Lim, Eric, Harris, Rosie A, McKeon, Holly E, Batchelor, Timothy Jp, Dunning, Joel, Shackcloth, Michael, Anikin, Vladimir, Naidu, Babu, Belcher, Elizabeth, Loubani, Mahmoud, Zamvar, Vipin, Dabner, Lucy, Brush, Timothy, Stokes, Elizabeth A, Wordsworth, Sarah, Paramasivan, Sangeetha, Realpe, Alba, Elliott, Daisy, Blazeby, Jane, Rogers, Chris A

“…Lung cancer is the leading cause of cancer death. Surgery remains the main method of managing early-stage disease. Minimal-access video-assisted thoracoscopic…”
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Efficacy of propofol-supplemented cardioplegia on biomarkers of organ injury in patients having cardiac surgery using cardiopulmonary bypass: a statistical analysis plan for the ProMPT-2 randomised controlled trial by Smartt, Helena, Angelini, Gianni D, Gibbison, Ben, Rogers, Chris A

“…The ProMPT-2 trial (Propofol for Myocardial Protection Trial #2) aims to compare the safety and efficacy of low- and high-dose propofol supplementation of the…”
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Emulating the MERINO randomised control trial using data from an observational cohort and trial of rapid diagnostic (BSI-FOO) by Evans, Rebecca N, Harris, Jessica, Rogers, Chris A, MacGowan, Alasdair

“…The aim of this study was to emulate the MERINO trial of piperacillin-tazobactam vs meropenem for the definitive treatment of bloodstream infection (BSI)…”
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Approaches to multiplicity in publicly funded pragmatic randomised controlled trials: a survey of clinical trials units and a rapid review of published trials by Pike, Katie, Reeves, Barnaby C, Rogers, Chris A

“…Opinions and practices vary around the issue of performing multiple statistical tests in randomised controlled trials (RCTs). We carried out a study to collate…”
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Conveying Equipoise during Recruitment for Clinical Trials: Qualitative Synthesis of Clinicians' Practices across Six Randomised Controlled Trials by Rooshenas, Leila, Elliott, Daisy, Wade, Julia, Jepson, Marcus, Paramasivan, Sangeetha, Strong, Sean, Wilson, Caroline, Beard, David, Blazeby, Jane M, Birtle, Alison, Halliday, Alison, Rogers, Chris A, Stein, Rob, Donovan, Jenny L

“…Randomised controlled trials (RCTs) are essential for evidence-based medicine and increasingly rely on front-line clinicians to recruit eligible patients…”
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Analytical challenges in estimating the effect of exposures that are bounded by follow-up time: experiences from the Blood Stream Infection-Focus on Outcomes study by Evans, Rebecca, Pike, Katie, MacGowan, Alasdair, Rogers, Chris A

“…To illustrate the challenges of estimating the effect of an exposure that is bounded by duration of follow-up on all-cause 28-day mortality, whilst…”
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The EQ-5D-5L is a valid approach to measure health related quality of life in patients undergoing bariatric surgery by Fermont, Jilles M, Blazeby, Jane M, Rogers, Chris A, Wordsworth, Sarah

“…Bariatric surgery is considered an effective treatment for individuals with severe and complex obesity. Besides reducing weight and improving obesity related…”
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Integrating expert opinions with clinical trial data to analyse low-powered subgroup analyses: a Bayesian analysis of the VeRDiCT trial by Thirard, Russell, Ascione, Raimondo, Blazeby, Jane M, Rogers, Chris A

“…Typically, subgroup analyses in clinical trials are conducted by comparing the intervention effect in each subgroup by means of an interaction test. However,…”
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Home-monitoring for neovascular age-related macular degeneration in older adults within the UK: the MONARCH diagnostic accuracy study by Hogg, Ruth E, Wickens, Robin, O'Connor, Sean, Gidman, Eleanor, Ward, Elizabeth, Treanor, Charlene, Peto, Tunde, Burton, Ben, Knox, Paul, Lotery, Andrew J, Sivaprasad, Sobha, Donnelly, Michael, Rogers, Chris A, Reeves, Barnaby C

“…Most neovascular age-related macular degeneration treatments involve long-term follow-up of disease activity. Home monitoring would reduce the burden on…”
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A Core Outcome Set for the Benefits and Adverse Events of Bariatric and Metabolic Surgery: The BARIACT Project by Coulman, Karen D, Hopkins, James, Brookes, Sara T, Chalmers, Katy, Main, Barry, Owen-Smith, Amanda, Andrews, Robert C, Byrne, James, Donovan, Jenny L, Mazza, Graziella, Reeves, Barnaby C, Rogers, Chris A, Thompson, Janice L, Welbourn, Richard, Wordsworth, Sarah, Blazeby, Jane M

“…Bariatric and metabolic surgery is used as a treatment for patients with severe and complex obesity. However, there is a need to improve outcome selection and…”
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Using trials of caloric restriction and bariatric surgery to explore the effects of body mass index on the circulating proteome by Goudswaard, Lucy J., Smith, Madeleine L., Hughes, David A., Taylor, Roy, Lean, Michael, Sattar, Naveed, Welsh, Paul, McConnachie, Alex, Blazeby, Jane M., Rogers, Chris A., Suhre, Karsten, Zaghlool, Shaza B., Hers, Ingeborg, Timpson, Nicholas J., Corbin, Laura J.

“…Thousands of proteins circulate in the bloodstream; identifying those which associate with weight and intervention-induced weight loss may help explain…”
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Supraglottic airway device versus tracheal intubation in the initial airway management of out-of-hospital cardiac arrest: the AIRWAYS-2 cluster RCT by Benger, Jonathan R, Kirby, Kim, Black, Sarah, Brett, Stephen J, Clout, Madeleine, Lazaroo, Michelle J, Nolan, Jerry P, Reeves, Barnaby C, Robinson, Maria, Scott, Lauren J, Smartt, Helena, South, Adrian, Stokes, Elizabeth A, Taylor, Jodi, Thomas, Matthew, Voss, Sarah, Wordsworth, Sarah, Rogers, Chris A

“…When a cardiac arrest occurs, cardiopulmonary resuscitation should be started immediately. However, there is limited evidence about the best approach to airway…”
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Strategies to address recruitment to a randomised trial of surgical and non-surgical treatment for cancer: results from a complex recruitment intervention within the Mesothelioma and Radical Surgery 2 (MARS 2) study by Mills, Nicola, Farrar, Nicola, Warnes, Barbara, Ashton, Kate E, Harris, Rosie, Rogers, Chris A, Lim, Eric, Elliott, Daisy

“…ObjectivesRecruiting to randomised trials is often challenging particularly when the intervention arms are markedly different. The Mesothelioma and Radical…”
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Development of a framework to improve the process of recruitment to randomised controlled trials (RCTs): the SEAR (Screened, Eligible, Approached, Randomised) framework by Wilson, Caroline, Rooshenas, Leila, Paramasivan, Sangeetha, Elliott, Daisy, Jepson, Marcus, Strong, Sean, Birtle, Alison, Beard, David J, Halliday, Alison, Hamdy, Freddie C, Lewis, Rebecca, Metcalfe, Chris, Rogers, Chris A, Stein, Robert C, Blazeby, Jane M, Donovan, Jenny L

“…Research has shown that recruitment to trials is a process that stretches from identifying potentially eligible patients, through eligibility assessment, to…”
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An open randomized controlled trial of median sternotomy versus anterolateral left thoracotomy on morbidity and health care resource use in patients having off-pump coronary artery bypass surgery: The Sternotomy Versus Thoracotomy (STET) trial by Rogers, Chris A., PhD, Pike, Katie, MSc, Angelini, Gianni D., FRCS, Reeves, Barnaby C., DPhil, Glauber, Mattia, MD, Ferrarini, Matteo, MD, Murphy, Gavin J., FRCS

“…Objective Our objective was to compare off-pump coronary artery bypass surgery carried out via a left anterolateral thoracotomy (ThoraCAB) or via a…”
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Working under short timescales to deliver a national trial: a case study of the ComFluCOV trial from a statistician's perspective by Harris, Rosie, Thirard, Russell, Baos, Sarah, Lazarus, Rajeka, Todd, Rachel, Kirwan, Jana, Joyce, Katherine, Hutton, David, Clout, Maddie, Cappel-Porter, Heike, Culliford, Lucy, Rogers, Chris A

“…In early 2021, the Department of Health and Social Care in the UK called for research on the safety and immunogenicity of concomitant administration of…”
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Delivering COVID-19 vaccine trials at speed: the implementation of a phase IV UK multi-centre randomised controlled trial to determine safety and immunogenicity of COVID-19 vaccines co-administered with seasonal influenza vaccines (ComFluCOV) by Baos, Sarah, Todd, Rachel, Thirard, Russell, Harris, Rosie, Kirwan, Jana, Joyce, Katherine, Hutton, David, Finn, Adam, Clout, Madeleine, Cappel-Porter, Heike, Rogers, Chris A, Lazarus, Rajeka, Culliford, Lucy

“…In February 2021, the UK Department of Health and Social Care sought evidence on the safety and immunogenicity of COVID-19 and influenza vaccine…”
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