Search Results - "Roger Chammas"

Phosphatidylcholine-Derived Lipid Mediators: The Crosstalk Between Cancer Cells and Immune Cells by Saito, Renata de Freitas, Andrade, Luciana Nogueira de Sousa, Bustos, Silvina Odete, Chammas, Roger

“…To become resistant, cancer cells need to activate and maintain molecular defense mechanisms that depend on an energy trade-off between resistance and…”
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Emerging Autophagy Functions Shape the Tumor Microenvironment and Play a Role in Cancer Progression - Implications for Cancer Therapy by Bustos, Silvina Odete, Antunes, Fernanda, Rangel, Maria Cristina, Chammas, Roger

“…The tumor microenvironment (TME) is a complex environment where cancer cells reside and interact with different types of cells, secreted factors, and the…”
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Mannose receptor 1 expression does not determine the uptake of high-density mannose dendrimers by activated macrophages populations by Kovacs, Luciana, Cabral, Pablo, Chammas, Roger

“…The presence of a high number of macrophages within solid tumors is often significantly associated with poor prognosis and predict treatment failure for…”
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deltaXpress (ΔXpress): a tool for mapping differentially correlated genes using single-cell qPCR data by Murillo Carrasco, Alexis Germán, Furuya, Tatiane Katsue, Uno, Miyuki, Citrangulo Tortelli, Tharcisio, Chammas, Roger

“…High-throughput experiments provide deep insight into the molecular biology of different species, but more tools need to be developed to handle this type of…”
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Rethinking approaches of science, technology, and innovation in healthcare during the COVID-19 pandemic: the challenge of translating knowledge infrastructures to public needs by da Silva, Renan Gonçalves Leonel, Chammas, Roger, Novaes, Hillegonda Maria Dutilh

“…The coronavirus disease 2019 (COVID-19) outbreak made it clear that despite the potential of science, technology, and innovation (ST&I) to positively impact…”
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Sialylation of β1 Integrins Blocks Cell Adhesion to Galectin-3 and Protects Cells against Galectin-3-induced Apoptosis by Zhuo, Ya, Chammas, Roger, Bellis, Susan L.

“…In previous studies, we determined that β1 integrins from human colon tumors have elevated levels of α2-6 sialylation, a modification added by β-galactosamide…”
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Editorial: Pharmacology of gangliosides by Zhuang, Hongda, Huang, Zhendong, Birklé, Stéphane, Chammas, Roger, Tikkanen, Ritva, Chen, Yong

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The role of kinin receptors in cancer and therapeutic opportunities by da Costa, Patrícia L.N, Sirois, Pierre, Tannock, Ian F, Chammas, Roger

“…Abstract Kinins are generated within inflammatory tissue microenvironments, where they exert diverse functions, including cell proliferation, leukocyte…”
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Resistance Mechanisms Influencing Oncolytic Virotherapy, a Systematic Analysis by Bhatt, Darshak K., Chammas, Roger, Daemen, Toos

“…Resistance to therapy is a frequently observed phenomenon in the treatment of cancer, and as with other cancer therapeutics, therapies based on oncolytic…”
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Pre- and postnatal exposure of mice to concentrated urban PM2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life by de Barros Mendes Lopes, Thais, Groth, Espen E., Veras, Mariana, Furuya, Tatiane K., de Souza Xavier Costa, Natalia, Ribeiro Júnior, Gabriel, Lopes, Fernanda Degobbi, de Almeida, Francine M., Cardoso, Wellington V., Saldiva, Paulo Hilario Nascimento, Chammas, Roger, Mauad, Thais

“…Gestational exposure to air pollution is associated with negative outcomes in newborns and children. In a previous study, we demonstrated a synergistic…”
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PAF receptor and tumor growth by Jancar, Sonia, Chammas, Roger

“…The receptor for the lipid mediator PAF (PAFR) is a G-protein coupled receptor expressed in several cell types. Besides PAF, a series of oxidized phospholipids…”
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Association of COX-inhibitors with cancer patients' survival under chemotherapy and radiotherapy regimens: a real-world data retrospective cohort analysis by Flausino, Lucas E, Ferreira, Isabella N, Tuan, Wen-Jan, Estevez-Diz, Maria Del Pilar, Chammas, Roger

“…We conducted an extensive, sex-oriented real-world data analysis to explore the impact and safety of non-steroidal anti-inflammatory drugs (NSAIDs) and…”
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Deciphering the Functional Status of Breast Cancers through the Analysis of Their Extracellular Vesicles by Murillo Carrasco, Alexis Germán, Otake, Andreia Hanada, Macedo-da-Silva, Janaina, Feijoli Santiago, Veronica, Palmisano, Giuseppe, Andrade, Luciana Nogueira de Sousa, Chammas, Roger

“…Breast cancer (BC) accounts for the highest incidence of tumor-related mortality among women worldwide, justifying the growing search for molecular tools for…”
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Plasma Exosome-Derived microRNAs as Potential Diagnostic and Prognostic Biomarkers in Brazilian Pancreatic Cancer Patients by Marin, Anelis Maria, Mattar, Sibelle Botogosque, Amatuzzi, Rafaela Ferreira, Chammas, Roger, Uno, Miyuki, Zanette, Dalila Luciola, Aoki, Mateus Nóbrega

“…Pancreatic cancer represents one of the leading causes of oncological death worldwide. A combination of pancreatic cancer aggressiveness and late diagnosis are…”
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Arg72Pro TP53 polymorphism and cancer susceptibility: A comprehensive meta‐analysis of 302 case‐control studies by Francisco, Guilherme, Menezes, Paulo Rossi, Eluf‐Neto, José, Chammas, Roger

“…Arg72Pro is a common polymorphism in TP53, showing differences in its biological functions. Case‐control studies have been performed to elucidate the role of…”
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Melatonin Regulates the Daily Levels of Plasma Amino Acids, Acylcarnitines, Biogenic Amines, Sphingomyelins, and Hexoses in a Xenograft Model of Triple Negative Breast Cancer by Junior, Rubens Paula, Chuffa, Luiz Gustavo de Almeida, Simão, Vinicius Augusto, Sonehara, Nathália Martins, Chammas, Roger, Reiter, Russel J., Zuccari, Debora Aparecida Pires de Campos

“…Metabolic dysregulation as a reflection of specific metabolite production and its utilization is a common feature of many human neoplasms. Melatonin, an…”
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Galectin-3 up-regulation in hypoxic and nutrient deprived microenvironments promotes cell survival by Ikemori, Rafael Yamashita, Machado, Camila Maria Longo, Furuzawa, Karina Mie, Nonogaki, Suely, Osinaga, Eduardo, Umezawa, Kazuo, de Carvalho, Marcelo Alex, Verinaud, Liana, Chammas, Roger

“…Galectin-3 (gal-3) is a β-galactoside binding protein related to many tumoral aspects, e.g. angiogenesis, cell growth and motility and resistance to cell…”
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Emerging technologies in extracellular vesicle-based molecular diagnostics by Jia, Shidong, Zocco, Davide, Samuels, Michael L, Chou, Michael F, Chammas, Roger, Skog, Johan, Zarovni, Natasa, Momen-Heravi, Fatemeh, Kuo, Winston Patrick

“…Extracellular vesicles (EVs), including exosomes and microvesicles, have been shown to carry a variety of biomacromolecules including mRNA, microRNA and other…”
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Repurposing an atherosclerosis targeting peptide for tumor imaging by Kovacs, Luciana, Davis, Ryan A., Ganguly, Tanushree, Chammas, Roger, Sutcliffe, Julie L.

“…Cancer and atherosclerosis are chronic diseases that share common characteristics at both early and advanced stages and can arise from multiple factors. Both…”
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Screening of Exosome-Derived Proteins and Their Potential as Biomarkers in Diagnostic and Prognostic for Pancreatic Cancer by Marin, Anelis Maria, Batista, Michel, Korte de Azevedo, Alexandre Luiz, Bombardelli Gomig, Talita Helen, Soares Caldeira Brant, Rodrigo, Chammas, Roger, Uno, Miyuki, Dias Araújo, Diogo, Zanette, Dalila Luciola, Nóbrega Aoki, Mateus

“…In the oncological area, pancreatic cancer is one of the most lethal diseases, with 5-year survival rising just 10% in high-development countries. This disease…”
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