Search Results - "Rogel, Anne"

Fcγ receptor binding is required for maximal immunostimulation by CD70-Fc by Dadas, Osman, Allen, Joel D, Buchan, Sarah L, Kim, Jinny, Chan, H T Claude, Mockridge, C Ian, Duriez, Patrick J, Rogel, Anne, Crispin, Max, Al-Shamkhani, Aymen

“…T cell expressed CD27 provides costimulation upon binding to inducible membrane expressed trimeric CD70 and is required for protective CD8 T cell responses…”
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Fcγ receptor-mediated cross-linking codefines the immunostimulatory activity of anti-human CD96 antibodies by Rogel, Anne, Ibrahim, Fathima M, Thirdborough, Stephen M, Renart-Depontieu, Florence, Birts, Charles N, Buchan, Sarah L, Preville, Xavier, King, Emma V, Al-Shamkhani, Aymen

“…New strategies that augment T cell responses are required to broaden the therapeutic arsenal against cancer. CD96, TIGIT, and CD226 are receptors that bind to…”
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MELOE-1 antigen contains multiple HLA class II T cell epitopes recognized by Th1 CD4+ T cells from melanoma patients by Bobinet, Mathilde, Vignard, Virginie, Rogel, Anne, Khammari, Amir, Dreno, Brigitte, Lang, Francois, Labarriere, Nathalie

“…MELOE-1 is an overexpressed melanoma antigen containing a HLA-A2 restricted epitope, involved in melanoma immunosurveillance of patients adoptively transferred…”
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The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy by Buchan, Sarah L., Rogel, Anne, Al-Shamkhani, Aymen

“…In recent years, monoclonal antibodies (mAbs) able to reinvigorate antitumor T-cell immunity have heralded a paradigm shift in cancer treatment. The most high…”
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PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8 + T-Cell-Driven Antitumor Immunity by Buchan, Sarah L, Fallatah, Mohannad, Thirdborough, Stephen M, Taraban, Vadim Y, Rogel, Anne, Thomas, Lawrence J, Penfold, Christine A, He, Li-Zhen, Curran, Michael A, Keler, Tibor, Al-Shamkhani, Aymen

“…PD-1 checkpoint blockade has revolutionized the field of cancer immunotherapy, yet the frequency of responding patients is limited by inadequate T-cell priming…”
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Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function by Buchan, Sarah L., Dou, Lang, Remer, Marcus, Booth, Steven G., Dunn, Stuart N., Lai, Chester, Semmrich, Monika, Teige, Ingrid, Mårtensson, Linda, Penfold, Christine A., Chan, H.T. Claude, Willoughby, Jane E., Mockridge, C. Ian, Dahal, Lekh N., Cleary, Kirstie L.S., James, Sonya, Rogel, Anne, Kannisto, Päivi, Jernetz, Mats, Williams, Emily L., Healy, Eugene, Verbeek, J. Sjef, Johnson, Peter W.M., Frendéus, Björn, Cragg, Mark S., Glennie, Martin J., Gray, Juliet C., Al-Shamkhani, Aymen, Beers, Stephen A.

“…The costimulatory receptor 4-1BB is expressed on activated immune cells, including activated T cells. Antibodies targeting 4-1BB enhance the proliferation and…”
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Akt signaling is critical for memory CD8⁺ T-cell development and tumor immune surveillance by Rogel, Anne, Willoughby, Jane E., Buchan, Sarah L., Leonard, Henry J., Thirdborough, Stephen M., Al-Shamkhani, Aymen

“…Memory CD8⁺ T cells confer long-term immunity against tumors, and anticancer vaccines therefore should maximize their generation. Multiple memory CD8⁺ T-cell…”
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OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence by Buchan, Sarah, Manzo, Teresa, Flutter, Barry, Rogel, Anne, Edwards, Noha, Zhang, Lei, Sivakumaran, Shivajanani, Ghorashian, Sara, Carpenter, Ben, Bennett, Clare, Freeman, Gordon J, Sykes, Megan, Croft, Michael, Al-Shamkhani, Aymen, Chakraverty, Ronjon

“…Exhaustion of chronically stimulated CD8(+) T cells is a significant obstacle to immune control of chronic infections or tumors. Although coinhibitory…”
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Differential impact of CD27 and 4-1BB costimulation on effector and memory CD8 T cell generation following peptide immunization by Willoughby, Jane E, Kerr, Jonathan P, Rogel, Anne, Taraban, Vadim Y, Buchan, Sarah L, Johnson, Peter W M, Al-Shamkhani, Aymen

“…The factors that determine differentiation of naive CD8 T cells into memory cells are not well understood. A greater understanding of how memory cells are…”
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CD137 on inflamed lymphatic endothelial cells enhances CCL21‐guided migration of dendritic cells by Teijeira, Álvaro, Palazón, Asís, Garasa, Saray, Marré, Diego, Aubá, Cristina, Rogel, Anne, Murillo, Ohiana, Martínez‐Forero, Iván, Lang, François, Melero, Ignacio, Rouzaut, Ana

“…ABSTRACT CD137/TNFR9/41BB was originally described as a surface molecule present on activated T and NK cells. However, its expression is broader among…”
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PD-1 blockade and CD27 stimulation activate distinct transcriptional programs that synergize for CD8+ T-cell driven anti-tumor immunity by Buchan, Sarah L., Fallatah, Mohannad, Thirdborough, Stephen M., Taraban, Vadim Y., Rogel, Anne, Thomas, Lawrence J., Penfold, Christine A., He, Li-Zhen, Curran, Michael A., Keler, Tibor, Al-Shamkhani, Aymen

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long peptide from MELOE-1 contains multiple HLA class II T cell epitopes in addition to the HLA-A0201 epitope: an attractive candidate for melanoma vaccination by Rogel, Anne, Vignard, Virginie, Bobinet, Mathilde, Labarriere, Nathalie, Lang, François

“…CD4⁺ T cells contribute importantly to the antitumor T cell response, and thus, long peptides comprising CD4 and CD8 epitopes may be efficient cancer vaccines…”
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OX40- and CD27-mediated co-stimulation synergize with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence by Buchan, Sarah, Manzo, Teresa, Flutter, Barry, Rogel, Anne, Edwards, Noha, Zhang, Lei, Sivakumaran, Shivajanani, Ghorashian, Sara, Carpenter, Ben, Bennett, Clare, Freeman, Gordon J., Sykes, Megan, Croft, Michael, Al-Shamkhani, Aymen, Chakraverty, Ronjon

“…Exhaustion of chronically stimulated CD8 + T cells is a significant obstacle to immune control of chronic infections or tumors. Although co-inhibitory…”
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