Search Results - "Rogalska, Malgorzata Ewa"

Improvement of SMN2 Pre-mRNA Processing Mediated by Exon-Specific U1 Small Nuclear RNA by Dal Mas, Andrea, Rogalska, Malgorzata Ewa, Bussani, Erica, Pagani, Franco

“…Exon-specific U1 snRNAs (ExSpe U1s) are modified U1 snRNAs that interact with intronic sequences downstream of the 5′ splice site (ss) by complementarity. This…”
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Therapeutic activity of modified U1 core spliceosomal particles by Rogalska, Malgorzata Ewa, Tajnik, Mojca, Licastro, Danilo, Bussani, Erica, Camparini, Luca, Mattioli, Chiara, Pagani, Franco

“…Modified U1 snRNAs bound to intronic sequences downstream of the 5′ splice site correct exon skipping caused by different types of mutations. Here we evaluate…”
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Molecular Basis and Therapeutic Strategies to Rescue Factor IX Variants That Affect Splicing and Protein Function by Tajnik, Mojca, Rogalska, Malgorzata Ewa, Bussani, Erica, Barbon, Elena, Balestra, Dario, Pinotti, Mirko, Pagani, Franco

“…Mutations that result in amino acid changes can affect both pre-mRNA splicing and protein function. Understanding the combined effect is essential for correct…”
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Evolutionary analysis reveals the role of a non-catalytic domain of peptidyl arginine deiminase 2 in transcriptional regulation by Villanueva-Cañas, José Luis, Fernandez-Fuentes, Narcis, Saul, Dominik, Kosinsky, Robyn Laura, Teyssier, Catherine, Rogalska, Malgorzata Ewa, Pérez, Ferran Pegenaute, Oliva, Baldomero, Notredame, Cedric, Beato, Miguel, Sharma, Priyanka

“…Peptidyl arginine deiminases (PADIs) catalyze protein citrullination, a post-translational conversion of arginine to citrulline. The most widely expressed…”
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IQGAP1 mediates the communication between the nucleus and the mitochondria via NDUFS4 alternative splicing by Papadaki, Vasiliki, Erpapazoglou, Zoi, Kokkori, Maria, Rogalska, Malgorzata Ewa, Potiri, Myrto, Birladeanu, Andrada, Tsakiri, Eleni N, Ashktorab, Hassan, Smoot, Duane T, Papanikolopoulou, Katerina, Samiotaki, Martina, Kafasla, Panagiota

“…Abstract Constant communication between mitochondria and nucleus ensures cellular homeostasis and adaptation to mitochondrial stress. Anterograde regulatory…”
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An Exon-Specific U1snRNA Induces a Robust Factor IX Activity in Mice Expressing Multiple Human FIX Splicing Mutants by Balestra, Dario, Scalet, Daniela, Pagani, Franco, Rogalska, Malgorzata Ewa, Mari, Rosella, Bernardi, Francesco, Pinotti, Mirko

“…In cellular models we have demonstrated that a unique U1snRNA targeting an intronic region downstream of a defective exon (Exon-specific U1snRNA, ExSpeU1) can…”
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Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects by Rogalska, Malgorzata Ewa, Vivori, Claudia, Valcárcel, Juan

“…The removal of introns from mRNA precursors and its regulation by alternative splicing are key for eukaryotic gene expression and cellular function, as…”
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Rescue of common exon‐skipping mutations in cystic fibrosis with modified U1 snRNAs by Donegà, Stefano, Rogalska, Malgorzata Ewa, Pianigiani, Giulia, Igreja, Susana, Amaral, Margarida Duarte, Pagani, Franco

“…In cystic fibrosis (CF), the correction of splicing defects represents an interesting therapeutic approach to restore normal CFTR function. In this study, we…”
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Proteomic study identifies Aurora-A mediated regulation of alternative splicing through multiple splicing factors by Prasath Damodaran, Arun, Gavard, Olivia, Gagné, Jean-Philippe, Rogalska, Malgorzata Ewa, Behera, Amit K., Mancini, Estefania, Bertolin, Giulia, Courtheoux, Thibault, Kumari, Bandana, Cailloce, Justine, Mereau, Agnès, Poirier, Guy G., Valcárcel, Juan, Gonatopoulos-Pournatzis, Thomas, Watrin, Erwan, Prigent, Claude

“…The cell cycle regulator Aurora-A kinase presents an attractive target for cancer therapies, though its inhibition is also associated with toxic side effects…”
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