Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer

Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer

The gut microbiome has increasingly been recognized as a critical and central factor in inflammatory bowel disease (IBD). Here, we review specific microorganisms that have been suggested to play a role in the pathogenesis of IBD and the current state of fecal microbial transplants as a therapeutic s...

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Bibliographic Details
Published in:Microorganisms (Basel) Vol. 10; no. 7; p. 1371
Main Authors: Gubatan, John, Boye, Theresa Louise, Temby, Michelle, Sojwal, Raoul S, Holman, Derek R, Sinha, Sidhartha R, Rogalla, Stephan R, Nielsen, Ole Haagen
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 07-07-2022
MDPI
Subjects:
Antibiotics
Bacteria
Colitis
Colon
Colon cancer
Complications and side effects
Crohn’s disease
Dark matter
diet
Genes
gut microbiome
Immune system
Inflammatory bowel disease
Inflammatory bowel diseases
Intestinal microflora
Intestine
Microbiomes
Microbiota
Microorganisms
Pathogenesis
Peptides
Physiological aspects
Remission (Medicine)
Review
Transplants
ulcerative colitis
Viruses
United States
gut microbiome
colon cancer
ulcerative colitis
diet
immunity
inflammatory bowel disease
Crohn’s disease
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Summary:The gut microbiome has increasingly been recognized as a critical and central factor in inflammatory bowel disease (IBD). Here, we review specific microorganisms that have been suggested to play a role in the pathogenesis of IBD and the current state of fecal microbial transplants as a therapeutic strategy in IBD. We discuss specific nutritional and dietary interventions in IBD and their effects on gut microbiota composition. Finally, we examine the role and mechanisms of the gut microbiome in mediating colitis-associated colon cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms10071371