Search Results - "Rogachevskii, V. V."
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New approaches to the design of analgesic medicinal substances
Published in Canadian journal of physiology and pharmacology (01-01-2022)“…A gamma-pyrone derivative, comenic acid, activates the opioid-like receptor-mediated signaling pathway that modulates the Na 1.8 channels in the primary…”
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Role of the Guanidinium Groups in Ligand–Receptor Binding of Arginine-Containing Short Peptides to the Slow Sodium Channel: Quantitative Approach to Drug Design of Peptide Analgesics
Published in International journal of molecular sciences (13-09-2022)“…Several arginine-containing short peptides have been shown by the patch-clamp method to effectively modulate the NaV1.8 channel activation gating system, which…”
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Arginine-Containing Tripeptides as Analgesic Substances: The Possible Mechanism of Ligand-Receptor Binding to the Slow Sodium Channel
Published in International journal of molecular sciences (26-05-2022)“…Two short arginine-containing tripeptides, H-Arg-Arg-Arg-OH (TP1) and Ac-Arg-Arg-Arg-NH (TP2), have been shown by the patch-clamp method to modulate the Na 1.8…”
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Electron Microscopy of Stable Electrophoretic Fractions of Natural Humic Acids as a Key to the Understanding of Their Structural Organization
Published in Russian journal of bioorganic chemistry (2024)“…Objective: Natural humic substances (HS) make up a significant part of the organic carbon of the biosphere. Considering the numerous significant ecological…”
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Role of the Rhamnosyl Residue of Ouabain in the Activation of the Na,K-ATPase Signaling Function
Published in Life (Basel, Switzerland) (01-07-2023)“…The signaling or non-pumping Na,K-ATPase function was first observed by us in the nociceptive neuron; Na,K-ATPase transduced the signals from the opioid-like…”
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Short Lysine-Containing Tripeptide as Analgesic Substance: The Possible Mechanism of Ligand-Receptor Binding to the Slow Sodium Channel
Published in Life (Basel, Switzerland) (01-10-2024)“…A possible molecular mechanism of the ligand-receptor binding of Ac-Lys-Lys-Lys-NH (Ac-KKK-NH ) to the Na 1.8 channel that is responsible for nociceptive…”
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Analgesic Effect of the Lysine-Containing Short Peptide Is Due to Modulation of the NaV1.8 Channel Activation Gating System
Published in Life (Basel, Switzerland) (24-08-2023)“…The present work continues our recent series of articles that aim to elucidate the ligand–receptor binding mechanism of short cationic peptides to the NaV1.8…”
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Molecular mechanisms and signaling by comenic acid in nociceptive neurons influence the pathophysiology of neuropathic pain
Published in Pathophysiology (Amsterdam) (01-09-2019)“…Comenic acid (CA), a specific agonist of opioid-like receptors, effectively and safely relieves neuropathic pain by decreasing the NaV1.8 channel voltage…”
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Possible Mechanism of Infrared Radiation Reception: The Role of the Temperature Factor
Published in Technical physics (01-02-2018)“…The role of the temperature factor in the mechanism of reception of the CO 2 laser low-power infrared (IR) radiation (λ = 10.6 μm) by a sensory neuron membrane…”
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Modulation of Voltage Sensitivity of Slow Sodium Channels by a Synthetic Cyclic Peptide
Published in Human physiology (01-09-2021)“…Effects of a synthetic cyclic peptide on the primary sensory neuron responses are investigated. A decrease in the Na V 1.8 channel voltage sensitivity upon…”
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Three-dimensional reconstruction of synapses and dendritic spines in the rat and ground squirrel hippocampus: new structural-functional paradigms for synaptic function
Published in Neuroscience and behavioral physiology (01-05-2005)“…Published data are reviewed along with our own data on synaptic plasticity and rearrangements of synaptic organelles in the central nervous system…”
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A method of mesa trimming with glass knives for obtaining large series of ultrathin sections
Published in Cell and tissue biology (01-09-2013)“…Ultrastructural analysis of tissue based on 3D reconstruction from serial ultrathin sections is one of the most adequate methods in studies of spatial…”
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Changes of activity of the protein-synthesizing system of brain neurons of the ground squirrel Citellus undulatus during hibernation and hypothermia
Published in Journal of evolutionary biochemistry and physiology (01-05-2006)“…Using fluorescent and electron microscopy a comparative analysis was performed of components of the protein-synthesizing system of hippocampal neurons both in…”
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Umbilical Cord Blood for Autologous Transfusion in the Early Postnatal Ontogeny: Analysis of Cell Composition and Viability during Long-Term Culturing
Published in Bulletin of experimental biology and medicine (01-02-2015)“…Changes in cell composition and viability as well as the content and functional activity of hemopoietic progenitor cells were analyzed during long-term (up to…”
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Changes in titin and myosin heavy chain isoform composition in skeletal muscles of Mongolian Gerbil (Meriones unguiculatus) after 12-day spaceflight
Published in Biophysics (Oxford) (01-09-2012)“…Changes of titin and myosin heavy chain isoform composition in skeletal muscles (m. soleus, m. gastrocnemius, m. tibialis anterior, m. psoas major) in…”
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Quantum-chemical study on calcium(II) chelates with ouabagenin
Published in Russian journal of organic chemistry (2011)“…Complete conformational analysis of 1: 1 calcium(II) chelates with ouabagenin was performed ab initio. Analysis of the effect of complex formation on the…”
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In vitro and in vivo effects of a perfluorocarbon emulsion on cells of the rat central nervous system
Published in Doklady. Biological sciences (01-11-2000)Get full text
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Electromagnetic loads of synchronous machines in asynchronous modes (taking into consideration current distribution in the damping winding)
Published in Russian electrical engineering (01-10-2012)“…Methods of studies are based on solving a nonlinear system of equations of magnetically connected circuits. Determination of the currents in elements of…”
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