Search Results - "Rofstad, Einar K."

Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma by Huang, Ruixia, Rofstad, Einar K

“…Integrins are a large family of adhesion molecules that mediate cell-cell and cell-extracellular matrix interactions. Among the 24 integrin isoforms, many have…”
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Antifibrotic therapy to normalize the tumor microenvironment by Hauge, Anette, Rofstad, Einar K

“…Most tumors develop abnormal fibrotic regions consisting of fibroblasts, immune cells, and a dense extracellular matrix (ECM) immersed in a viscous…”
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Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice by Rofstad, Einar K, Mathiesen, Berit, Kindem, Kristil, Galappathi, Kanthi

“…Extracellular pH (pH(e)) is lower in many tumors than in the corresponding normal tissue. The significance of acidic pH(e) in the development of metastatic…”
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Tumor Interstitial Fluid Pressure—A Link between Tumor Hypoxia, Microvascular Density, and Lymph Node Metastasis by Rofstad, Einar K, Galappathi, Kanthi, Mathiesen, Berit S

“…Abstract High microvascular density (MVD) in the primary tumor has been shown to be associated with increased incidence of lymph node metastases and poor…”
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Interstitial Fluid Pressure and Associated Lymph Node Metastasis Revealed in Tumors by Dynamic Contrast-Enhanced MRI by HOMPLAND, Tord, ELLINGSEN, Christine, ØVREBØ, Kirsti Marie, ROFSTAD, Einar K

“…Elevated interstitial fluid pressure (IFP) in tumors can cause metastatic dissemination and treatment resistance, but its study poses a challenge because of a…”
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Assessment of Hypoxic Tissue Fraction and Prediction of Survival in Cervical Carcinoma by Dynamic Contrast-Enhanced MRI by Gaustad, Jon-Vidar, Rofstad, Einar K.

“…Tumor hypoxia is a major cause of treatment resistance and poor survival in locally-advanced cervical carcinoma (LACC). It has been suggested that K trans and…”
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Bevacizumab treatment of meningeal melanoma metastases by Simonsen, Trude G, Gaustad, Jon-Vidar, Rofstad, Einar K

“…Melanoma patients with metastatic growth in the meninges have poor prognosis and few treatment options. Although treatment with BRAF inhibitors or immune…”
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Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination by Rofstad, Einar K., Gaustad, Jon‐Vidar, Egeland, Tormod A.M., Mathiesen, Berit, Galappathi, Kanthi

“…Clinical studies have shown that patients with highly hypoxic primary tumors may have poor disease‐free and overall survival rates. Studies of experimental…”
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Assessment of Intratumor Heterogeneity in Parametric Dynamic Contrast-Enhanced MR Images: A Comparative Study of Novel and Established Methods by Gaustad, Jon-Vidar, Rofstad, Einar K.

“…Intratumor heterogeneity is associated with aggressive disease and poor survival rates in several types of cancer. A novel method for assessing intratumor…”
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DCE-MRI–Derived Measures of Tumor Hypoxia and Interstitial Fluid Pressure Predict Outcomes in Cervical Carcinoma by Simonsen, Trude G., Lund, Kjersti V., Hompland, Tord, Kristensen, Gunnar B., Rofstad, Einar K.

“…The poor outcome of locally advanced cervical cancer has been associated with extensive hypoxia and high interstitial fluid pressure (IFP) in the primary…”
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Vascular abnormalities and development of hypoxia in microscopic melanoma xenografts by Gaustad, Jon-Vidar, Simonsen, Trude G, Andersen, Lise Mari K, Rofstad, Einar K

“…Studies investigating the oxygenation status and the development of hypoxia in microscopic tumors are sparse. The purpose of this study was to measure the…”
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DCE-MRI of the hypoxic fraction, radioresponsiveness, and metastatic propensity of cervical carcinoma xenografts by Ellingsen, Christine, Hompland, Tord, Galappathi, Kanthi, Mathiesen, Berit, Rofstad, Einar K

“…Abstract Background and purpose Locoregional treatment failure and poor survival rates are associated with extensive hypoxia in the primary tumor in advanced…”
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Metastatic pathway and the microvascular and physicochemical microenvironments of human melanoma xenografts by Huang, Ruixia, Andersen, Lise Mari K, Rofstad, Einar K

“…Malignant melanoma of the skin can metastasize through blood vessels and lymphatics. The primary tumor develops a vascular microenvironment characterized by…”
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DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts by Wegner, Catherine S., Hauge, Anette, Simonsen, Trude G., Gaustad, Jon-Vidar, Andersen, Lise Mari K., Rofstad, Einar K.

“…The purpose of this study was dual: to investigate (a) whether sunitinib may induce changes in tumor microvasculature and hypoxia in pancreatic ductal…”
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DCE-MRI of locally-advanced carcinoma of the uterine cervix: Tofts analysis versus non-model-based analyses by Lund, Kjersti V, Simonsen, Trude G, Kristensen, Gunnar B, Rofstad, Einar K

“…Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may provide biomarkers of the outcome of locally-advanced cervical carcinoma (LACC). There is,…”
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Fluctuating and Diffusion-Limited Hypoxia in Hypoxia-Induced Metastasis by Rofstad, Einar K, Galappathi, Kanthi, Mathiesen, Berit, Ruud, Else-Beate M

“…Purpose: Most tumors develop regions with hypoxic cells during growth, owing to permanent limitations in oxygen diffusion (chronic or diffusion-limited…”
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High interstitial fluid pressure is associated with tumor-line specific vascular abnormalities in human melanoma xenografts by Simonsen, Trude G, Gaustad, Jon-Vidar, Leinaas, Marit N, Rofstad, Einar K

“…Interstitial fluid pressure (IFP) is highly elevated in many solid tumors. High IFP has been associated with low radiocurability and high metastatic frequency…”
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Metastasis in Melanoma Xenografts Is Associated with Tumor Microvascular Density Rather than Extent of Hypoxia by Rofstad, Einar K., Mathiesen, Berit

“…The development of metastases has been shown to be associated with the microvascular density of the primary tumor in some clinical studies and with the extent…”
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Vascularization, Oxygenation, and the Effect of Sunitinib Treatment in Pancreatic Ductal Adenocarcinoma Xenografts by Gaustad, Jon-Vidar, Simonsen, Trude G., Wegner, Catherine S., Rofstad, Einar K.

“…The purpose of the study was to investigate vascularization, oxygenation, and the effect of sunitinib treatment in pancreatic ductal adenocarcinoma (PDAC)…”
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DCE-MRI of patient-derived xenograft models of uterine cervix carcinoma: associations with parameters of the tumor microenvironment by Hauge, Anette, Wegner, Catherine S, Gaustad, Jon-Vidar, Simonsen, Trude G, Andersen, Lise Mari K, Rofstad, Einar K

“…Abnormalities in the tumor microenvironment are associated with resistance to treatment, aggressive growth, and poor clinical outcome in patients with advanced…”
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