Search Results - "Roffel, Sanne"

Stimulation of oral fibroblast chemokine receptors identifies CCR3 and CCR4 as potential wound healing targets by Buskermolen, Jeroen K., Roffel, Sanne, Gibbs, Susan

“…The focus of this study was to determine which chemokine receptors are present on oral fibroblasts and whether these receptors influence proliferation,…”
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Multi-species oral biofilm promotes reconstructed human gingiva epithelial barrier function by Shang, Lin, Deng, Dongmei, Buskermolen, Jeroen Kees, Janus, Marleen Marga, Krom, Bastiaan Philip, Roffel, Sanne, Waaijman, Taco, van Loveren, Cor, Crielaard, Wim, Gibbs, Susan

“…Since the oral mucosa is continuously exposed to abundant microbes, one of its most important defense features is a highly proliferative, thick, stratified…”
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Nickel allergy is associated with a broad spectrum cytokine response by De Graaf, Niels P. J., Roffel, Sanne, Gibbs, Susan, Kleverlaan, Cees J., Lopez Gonzalez, Marta, Rustemeyer, Thomas, Feilzer, Albert J., Bontkes, Hetty J.

“…Background Nickel‐induced proliferation or cytokine release by peripheral blood mononuclear cells may be used for in vitro diagnosis of nickel allergy…”
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Commensal and Pathogenic Biofilms Alter Toll-Like Receptor Signaling in Reconstructed Human Gingiva by Shang, Lin, Deng, Dongmei, Buskermolen, Jeroen Kees, Roffel, Sanne, Janus, Marleen Marga, Krom, Bastiaan Philip, Crielaard, Wim, Gibbs, Susan

“…The balance between the host and microbe is pivotal for oral health. A dysbiotic oral microbiome and the subsequent host inflammatory response are causes for…”
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Stable reconstructed human gingiva-microbe interaction model: Differential response to commensals and pathogens by Zhang, Yan, Shang, Lin, Roffel, Sanne, Krom, Bastiaan P, Gibbs, Susan, Deng, Dongmei

“…To investigate human oral health and disease, models are required which represent the interactions between the oral mucosa and microbiome. Our aim was to…”
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Different wound healing properties of dermis, adipose, and gingiva mesenchymal stromal cells by Boink, Mireille A., van den Broek, Lenie J., Roffel, Sanne, Nazmi, Kamran, Bolscher, Jan G.M., Gefen, Amit, Veerman, Enno C.I., Gibbs, Susan

“…Oral wounds heal faster and with better scar quality than skin wounds. Deep skin wounds where adipose tissue is exposed, have a greater risk of forming…”
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Saliva-derived microcosm biofilms grown on different oral surfaces in vitro by Li, Xiaolan, Shang, Lin, Brandt, Bernd W., Buijs, Mark J., Roffel, Sanne, van Loveren, Cor, Crielaard, Wim, Gibbs, Susan, Deng, Dong Mei

“…The microbial composition of a specific oral niche could be influenced by initial bacterial adherence, nutrient and physiological property of the local…”
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The Influence of Chronic Wound Extracts on Inflammatory Cytokine and Histatin Stability by Boink, Mireille A, Roffel, Sanne, Nazmi, Kamran, van Montfrans, Catherine, Bolscher, Jan G M, Gefen, Amit, Veerman, Enno C I, Gibbs, Susan

“…Chronic ulcers represent a major health burden in our society. Despite many available therapies, a large number of ulcers do not heal. Protein based therapies…”
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Human saliva stimulates skin and oral wound healing in vitro by Rodrigues Neves, Charlotte, Buskermolen, Jeroen, Roffel, Sanne, Waaijman, Taco, Thon, Maria, Veerman, Enno, Gibbs, Susan

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Saliva-Derived Host Defense Peptides Histatin1 and LL-37 Increase Secretion of Antimicrobial Skin and Oral Mucosa Chemokine CCL20 in an IL-1α-Independent Manner by Veerman, Enno C. I., Bolscher, Jan G. M., Nazmi, Kamran, Roffel, Sanne, Boink, Mireille A., Gibbs, Susan

“…Even though skin and oral mucosae are continuously in contact with commensal and opportunistic microorganisms, they generally remain healthy and uninflamed…”
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Evaluation of a FRET-peptide substrate to predict virulence in Pseudomonas aeruginosa by Kaman, Wendy E, Arkoubi-El Arkoubi, Nora El, Roffel, Sanne, Endtz, Hubert P, van Belkum, Alex, Bikker, Floris J, Hays, John P

“…Pseudomonas aeruginosa produces a number of proteases that are associated with virulence and disease progression. A substrate able to detect P…”
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Streptococcus mitis enhances metal-induced apoptosis in reconstructed human gingiva but not skin by Zhang, Yan, Shang, Lin, Roffel, Sanne, Spiekstra, Sander W., Deng, Dongmei, Gibbs, Susan

“…Commensal bacteria colonizing oral mucosa and skin play an essential role in maintaining host-microbiome homeostasis. It is unknown whether cytotoxicity…”
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Differential influence of Streptococcus mitis on host response to metals in reconstructed human skin and oral mucosa by Shang, Lin, Deng, Dongmei, Roffel, Sanne, Gibbs, Susan

“…Background Skin and oral mucosa are continuously exposed to potential metal sensitizers while hosting abundant microbes, which may influence the host response…”
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Evaluation of a novel oral mucosa in vitro implantation model for analysis of molecular interactions with dental abutment surfaces by Roffel, Sanne, Wu, Gang, Nedeljkovic, Ivana, Meyer, Michael, Razafiarison, Tojo, Gibbs, Susan

“…Background Abutment surfaces are being designed to promote gingival soft tissue attachment and integration. This forms a seal around prosthetics and…”
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Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts by Reijnders, Christianne M A, van Lier, Amanda, Roffel, Sanne, Kramer, Duco, Scheper, Rik J, Gibbs, Susan

“…Currently, human skin equivalents (HSEs) used for in vitro assays (e.g., for wound healing) make use of primary human skin cells. Limitations of primary…”
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Monocytes co-cultured with reconstructed keloid and normal skin models skew towards M2 macrophage phenotype by Limandjaja, Grace C., Waaijman, Taco, Roffel, Sanne, Niessen, Frank B., Gibbs, Susan

“…Several abnormalities have been reported in the peripheral blood mononuclear cells of keloid-forming patients and particularly in the monocyte cell fraction…”
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Saliva derived cariogenic and gingivitis biofilms show immune evasion potential compared to commensal biofilms in a human organotypic gingiva model by Gibbs, Sue, Buskermolen, Jeroen, Krom, Bastiaan, Janus, Marleen, Roffel, Sanne

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Human saliva stimulates skin and oral wound healing in vitro by Rodrigues Neves, Charlotte, Buskermolen, Jeroen, Roffel, Sanne, Waaijman, Taco, Thon, Maria, Veerman, Enno, Gibbs, Susan

“…Despite continuous exposure to environmental pathogens, injured mucosa within the oral cavity heals faster and almost scar free compared with skin. Saliva is…”
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Methods to study differences in cell mobility during skin wound healing in vitro by Monsuur, Hanneke N, Boink, Mireille A, Weijers, Ester M, Roffel, Sanne, Breetveld, Melanie, Gefen, Amit, van den Broek, Lenie J, Gibbs, Susan

“…Abstract Wound healing events which occur in humans are difficult to study in animals due to differences in skin physiology. Furthermore there are increasing…”
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Non–heat inactivated autologous serum increases accuracy of in vitro CFSE lymphocyte proliferation test (LPT) for nickel by Graaf, Niels P. J., Bontkes, Hetty J., Roffel, Sanne, Kleverlaan, Cornelis J., Rustemeyer, Thomas, Gibbs, Sue, Feilzer, Albert J.

“…Background Skin patch testing is still seen as the gold standard for the diagnosis of allergic hypersensitivity. For several metals and for patients with a…”
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