Pilot study: immunohistochemistry expressions of vitamin D receptor associated with severity of disease in psoriasis patients

Pilot study: immunohistochemistry expressions of vitamin D receptor associated with severity of disease in psoriasis patients

Background Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation, differentiation abnormalities, and resistance to apoptosis. There are several factors that can affect psoriasis and vitamin D is one of the recently arisen. The role of vitamin D is mediate...

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Bibliographic Details
Published in:International journal of dermatology Vol. 59; no. 9; pp. 1092 - 1097
Main Authors: Chandra, Rudi, Roesyanto‐Mahadi, Irma D., Yosi, Ariyati
Format: Journal Article
Language:English
Published: England Blackwell Publishing Ltd 01-09-2020
Subjects:
Abnormalities
Adult
Apoptosis
Calciferol
Correlation analysis
Correlation coefficient
Correlation coefficients
Cross-Sectional Studies
Differentiation
Female
Humans
Immunohistochemistry
Keratinocytes
Male
Middle Aged
Pilot Projects
Psoriasis
Receptors
Receptors, Calcitriol - genetics
Severity of Illness Index
Skin diseases
Statistical analysis
Vitamin D
Vitamin D receptors
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Summary:Background Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation, differentiation abnormalities, and resistance to apoptosis. There are several factors that can affect psoriasis and vitamin D is one of the recently arisen. The role of vitamin D is mediated by vitamin D receptors (VDR) in target cells. VDR is a nuclear hormone that is involved in the antiproliferation and pro‐differentiation pathways in keratinocytes. However, until now vitamin D/VDR signaling in psoriasis has not been fully understood. Methods A cross‐sectional study that involved 28 skin specimens from psoriasis patients to assess the immunohistochemistry expressions of VDR as well as their association with severity and duration of psoriasis. Statistical analyses were performed using Spearman's correlation coefficients, with P <0.05 was considered statistically significant. Results In total, 28 specimens from psoriasis patients consisting of 60.7% women and 39.3% men, with mean age 41.28 ± 14.97 years, predominantly age group 46–55 years (25%), mean duration of disease 6.64 ± 4.26 years, and mean Psoriasis Area and Severity Index (PASI) score 19.23 ± 11.30. The immunohistochemistry expressions of VDR were predominantly strong (57.1%) and located in the basal layer (53.6%). There were a significant negative correlation between the expressions of VDR and PASI score (P <0.001, r = −0.719) and between the expressions of VDR and duration of disease in psoriasis (P = 0.020, r = −0.438). Conclusion VDR expressions and severity of psoriasis showed a strong significant negative correlation and also a moderate significant negative correlation between VDR expressions and duration of disease.
Bibliography:Conflict of interest: None.
Funding source: None.
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content type line 23
ISSN:0011-9059
1365-4632
DOI:10.1111/ijd.15018