Search Results - "Roering, Pia"

A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients by Tumiati, Manuela, Hietanen, Sakari, Hynninen, Johanna, Pietilä, Elina, Färkkilä, Anniina, Kaipio, Katja, Roering, Pia, Huhtinen, Kaisa, Alkodsi, Amjad, Li, Yilin, Lehtonen, Rainer, Erkan, Erdogan Pekcan, Tuominen, Minna M, Lehti, Kaisa, Hautaniemi, Sampsa K, Vähärautio, Anna, Grénman, Seija, Carpén, Olli, Kauppi, Liisa

“…Homologous recombination deficiency (HRD) correlates with platinum sensitivity in patients with ovarian cancer, which clinically is the most useful predictor…”
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Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status by Roering, Pia, Siddiqui, Arafat, Heuser, Vanina D., Potdar, Swapnil, Mikkonen, Piia, Oikkonen, Jaana, Li, Yilin, Pikkusaari, Sanna, Wennerberg, Krister, Hynninen, Johanna, Grenman, Seija, Huhtinen, Kaisa, Auranen, Annika, Carpén, Olli, Kaipio, Katja

“…Objective A major challenge in the treatment of platinum-resistant high-grade serous ovarian cancer (HGSOC) is lack of effective therapies. Much of ongoing…”
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REG4 Is Highly Expressed in Mucinous Ovarian Cancer: A Potential Novel Serum Biomarker by Lehtinen, Laura, Vesterkvist, Pia, Roering, Pia, Korpela, Taina, Hattara, Liisa, Kaipio, Katja, Mpindi, John-Patrick, Hynninen, Johanna, Auranen, Annika, Davidson, Ben, Haglund, Caj, Iljin, Kristiina, Grenman, Seija, Siitari, Harri, Carpen, Olli

“…Preoperative diagnostics of ovarian neoplasms rely on ultrasound imaging and the serum biomarkers CA125 and HE4. However, these markers may be elevated in…”
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Targeting DNA Homologous Repair Proficiency With Concomitant Topoisomerase II and c-Abl Inhibition by Siddiqui, Arafat, Tumiati, Manuela, Joko, Alia, Sandholm, Jouko, Roering, Pia, Aakko, Sofia, Vainionpää, Reetta, Kaipio, Katja, Huhtinen, Kaisa, Kauppi, Liisa, Tuomela, Johanna, Hietanen, Sakari

“…Critical DNA repair pathways become deranged during cancer development. This vulnerability may be exploited with DNA-targeting chemotherapy. Topoisomerase II…”
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Postoperative human epididymis protein 4 predicts primary therapy outcome in advanced epithelial ovarian cancer by Vallius, Tuulia, Hynninen, Johanna, Auranen, Annika, Matomäki, Jaakko, Oksa, Sinikka, Roering, Pia, Grènman, Seija

“…Primary chemotherapy treatment response monitoring in advanced epithelial ovarian cancer (EOC) is currently based on CT-imaging and serum CA125 values. Serum…”
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18F-FDG-PET/CT can identify histopathological non-responders to platinum-based neoadjuvant chemotherapy in advanced epithelial ovarian cancer by Vallius, Tuulia, Peter, Anniina, Auranen, Annika, Carpén, Olli, Kemppainen, Jukka, Matomäki, Jaakko, Oksa, Sinikka, Roering, Pia, Seppänen, Marko, Grénman, Seija, Hynninen, Johanna

“…The aim of this study was to examine the relationship between the reduction of maximum standardized uptake values (SUVmax) in 18F-FDG-PET/CT to…”
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ALDH1A1‐related stemness in high‐grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR‐PI3K/aurora kinase inhibitors by Kaipio, Katja, Chen, Ping, Roering, Pia, Huhtinen, Kaisa, Mikkonen, Piia, Östling, Päivi, Lehtinen, Laura, Mansuri, Naziha, Korpela, Taina, Potdar, Swapnil, Hynninen, Johanna, Auranen, Annika, Grénman, Seija, Wennerberg, Krister, Hautaniemi, Sampsa, Carpén, Olli

“…Poor chemotherapy response remains a major treatment challenge for high‐grade serous ovarian cancer (HGSC). Cancer stem cells are the major contributors to…”
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Abstract A57: Drug sensitivity and resistance testing (DSRT) of clinically important compounds on primary ovarian cancer cell lines by Roering, Pia, Mikkonen, Piia, Potdar, Swapnil, Wennerberg, Krister, Hynninen, Johanna, Grénman, Seija, Auranen, Annika, Carpén, Olli, Kaipio, Katja

“…Abstract The heterogeneity of chemoresponses in high-grade serous ovarian cancer (HGS-OvCa) presents a major clinical challenge. The inherited or acquired…”
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Abstract B43: Xenograft mouse models for ovarian cancer by Lamminen, Tarja, Kaipio, Katja, Mikkonen, Piia, Roering, Pia, Carpén, Olli

“…Abstract Ovarian cancer is the most lethal gynecologic malignancy in developed countries. The incidence is 1 in 70 women, and 5-year survival rate below 50 %…”
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Abstract PR17: Characterization of ascites and tumor-derived ovarian cancer stem-like cells by Kaipio, Katja, Chen, Ping, Huhtinen, Kaisa, Mikkonen, Piia, Ostling, Paivi, Mpindi, John Patrick, Lehtinen, Laura, Roering, Pia, Korpela, Taina, Wennerberg, Krister, Yadav, Bhagwan, Aittokallio, Tero, Kulesskiy, Evgeny, Hynninen, Johanna, Auranen, Annika, Grénman, Seija, Hautaniemi, Sampsa, Carpén, Olli

“…Abstract Intratumoral heterogeneity of high grade serous ovarian cancer (HGS-OvCa) provides a major challenge for current treatments. The non-responsiveness of…”
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18 F-FDG-PET/CT can identify histopathological non-responders to platinum-based neoadjuvant chemotherapy in advanced epithelial ovarian cancer by Vallius, Tuulia, Peter, Anniina, Auranen, Annika, Carpén, Olli, Kemppainen, Jukka, Matomäki, Jaakko, Oksa, Sinikka, Roering, Pia, Seppänen, Marko, Grénman, Seija, Hynninen, Johanna

“…Abstract Objective The aim of this study was to examine the relationship between the reduction of maximum standardized uptake values (SUVmax) in18 F-FDG-PET/CT…”
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Abstract B21: Characterization of primary high-grade serous ovarian cancer cell lines: Cell line and growth condition specific differences in stem cell marker expression and high-throughput drug screening by Roering, Pia, Mikkonen, Piia, Kaipio, Katja, Huhtinen, Kaisa, Hynninen, Johanna, Auranen, Annika, Kulesskiy, Evgeny, Yadav, Bhagwan, Aittokallio, Tero, Grénman, Seija, Wennerberg, Krister, Carpén, Olli

“…Abstract The primary treatment for advanced epithelial ovarian cancer is surgery combined with chemotherapy. Unfortunately, relapse is common and often…”
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