Search Results - "Roemer, Terry"

Global analysis of fungal morphology exposes mechanisms of host cell escape by O’Meara, Teresa R., Veri, Amanda O., Ketela, Troy, Jiang, Bo, Roemer, Terry, Cowen, Leah E.

“…Developmental transitions between single-cell yeast and multicellular filaments underpin virulence of diverse fungal pathogens. For the leading human fungal…”
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A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier by Hart, Elizabeth M., Mitchell, Angela M., Konovalova, Anna, Grabowicz, Marcin, Sheng, Jessica, Han, Xiaoqing, Rodriguez-Rivera, Frances P., Schwaid, Adam G., Malinverni, Juliana C., Balibar, Carl J., Bodea, Smaranda, Si, Qian, Wang, Hao, Homsher, Michelle F., Painter, Ronald E., Ogawa, Anthony K., Sutterlin, Holly, Roemer, Terry, Black, Todd A., Rothman, Deborah M., Walker, Scott S., Silhavy, Thomas J.

“…The development of new antimicrobial drugs is a priority to combat the increasing spread of multidrug-resistant bacteria. This development is especially…”
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The GPI anchor pathway: a promising antifungal target? by Mutz, Mitchell, Roemer, Terry

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Analysis of the Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrum of Staphylococcus aureus Identifies Mutations That Allow Differentiation of the Main Clonal Lineages by Josten, Michaele, Reif, Marion, Szekat, Christiane, Al-Sabti, Nahed, Roemer, Terry, Sparbier, Katrin, Kostrzewa, Markus, Rohde, Holger, Sahl, Hans-Georg, Bierbaum, Gabriele

“…Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification and in vitro analysis of the GatD/MurT enzyme-complex catalyzing lipid II amidation in Staphylococcus aureus by Münch, Daniela, Roemer, Terry, Lee, Sang Ho, Engeser, Marianne, Sahl, Hans Georg, Schneider, Tanja

“…The peptidoglycan of Staphylococcus aureus is characterized by a high degree of crosslinking and almost completely lacks free carboxyl groups, due to amidation…”
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Staphylococcus aureus Survives with a Minimal Peptidoglycan Synthesis Machine but Sacrifices Virulence and Antibiotic Resistance by Reed, Patricia, Atilano, Magda L, Alves, Renato, Hoiczyk, Egbert, Sher, Xinwei, Reichmann, Nathalie T, Pereira, Pedro M, Roemer, Terry, Filipe, Sérgio R, Pereira-Leal, José B, Ligoxygakis, Petros, Pinho, Mariana G

“…Many important cellular processes are performed by molecular machines, composed of multiple proteins that physically interact to execute biological functions…”
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Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model by Becker, Jeffrey M., Kauffman, Sarah J., Hauser, Melinda, Huang, Liyin, Lin, Molly, Sillaots, Susan, Jiang, Bo, Xu, Deming, Roemer, Terry, Rine, Jasper

“…One potentially rich source of possible targets for antifungal therapy are those Candida albicans genes deemed essential for growth under the standard culture…”
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Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus by Fedorova, Natalie D, Khaldi, Nora, Joardar, Vinita S, Maiti, Rama, Amedeo, Paolo, Anderson, Michael J, Crabtree, Jonathan, Silva, Joana C, Badger, Jonathan H, Albarraq, Ahmed, Angiuoli, Sam, Bussey, Howard, Bowyer, Paul, Cotty, Peter J, Dyer, Paul S, Egan, Amy, Galens, Kevin, Fraser-Liggett, Claire M, Haas, Brian J, Inman, Jason M, Kent, Richard, Lemieux, Sebastien, Malavazi, Iran, Orvis, Joshua, Roemer, Terry, Ronning, Catherine M, Sundaram, Jaideep P, Sutton, Granger, Turner, Geoff, Venter, J Craig, White, Owen R, Whitty, Brett R, Youngman, Phil, Wolfe, Kenneth H, Goldman, Gustavo H, Wortman, Jennifer R, Jiang, Bo, Denning, David W, Nierman, William C

“…We present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely…”
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Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch by Howe, John A., Xiao, Li, Fischmann, Thierry O., Wang, Hao, Tang, Haifeng, Villafania, Artjohn, Zhang, Rumin, Barbieri, Christopher M., Roemer, Terry

“…Bacterial riboswitches are non-coding RNA structural elements that direct gene expression in numerous metabolic pathways. The key regulatory roles of…”
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Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans by Xu, Deming, Jiang, Bo, Ketela, Troy, Lemieux, Sebastien, Veillette, Karynn, Martel, Nick, Davison, John, Sillaots, Susan, Trosok, Steve, Bachewich, Catherine, Bussey, Howard, Youngman, Phil, Roemer, Terry

“…Candida albicans is a prevalent fungal pathogen amongst the immunocompromised population, causing both superficial and life-threatening infections. Since C…”
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The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans by Thevissen, Karin, de Mello Tavares, Patricia, Xu, Deming, Blankenship, Jill, Vandenbosch, Davy, Idkowiak-Baldys, Jolanta, Govaert, Gilmer, Bink, Anna, Rozental, Sonia, de Groot, Piet W. J., Davis, Talya R., Kumamoto, Carol A., Vargas, Gabriele, Nimrichter, Leonardo, Coenye, Tom, Mitchell, Aaron, Roemer, Terry, Hannun, Yusuf A., Cammue, Bruno P. A.

“…Summary The antifungal plant defensin RsAFP2 isolated from radish interacts with fungal glucosylceramides and induces apoptosis in Candida albicans. To further…”
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Essential gene identification and drug target prioritization in Aspergillus fumigatus by Hu, Wenqi, Sillaots, Susan, Lemieux, Sebastien, Davison, John, Kauffman, Sarah, Breton, Anouk, Linteau, Annie, Xin, Chunlin, Bowman, Joel, Becker, Jeff, Jiang, Bo, Roemer, Terry

“…Aspergillus fumigatus is the most prevalent airborne filamentous fungal pathogen in humans, causing severe and often fatal invasive infections in…”
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Transcription Factor Substitution during the Evolution of Fungal Ribosome Regulation by Hogues, Hervé, Lavoie, Hugo, Sellam, Adnane, Mangos, Maria, Roemer, Terry, Purisima, Enrico, Nantel, André, Whiteway, Malcolm

“…Coordinated ribosomal protein (RP) gene expression is crucial for cellular viability, but the transcriptional network controlling this regulon has only been…”
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Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets by Mann, Paul A, Müller, Anna, Wolff, Kerstin A, Fischmann, Thierry, Wang, Hao, Reed, Patricia, Hou, Yan, Li, Wenjin, Müller, Christa E, Xiao, Jianying, Murgolo, Nicholas, Sher, Xinwei, Mayhood, Todd, Sheth, Payal R, Mirza, Asra, Labroli, Marc, Xiao, Li, McCoy, Mark, Gill, Charles J, Pinho, Mariana G, Schneider, Tanja, Roemer, Terry

“…Here we describe a chemical biology strategy performed in Staphylococcus aureus and Staphylococcus epidermidis to identify MnaA, a 2-epimerase that we…”
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Large‐scale essential gene identification in Candida albicans and applications to antifungal drug discovery by Roemer, Terry, Jiang, Bo, Davison, John, Ketela, Troy, Veillette, Karynn, Breton, Anouk, Tandia, Fatou, Linteau, Annie, Sillaots, Susan, Marta, Catarina, Martel, Nick, Veronneau, Steeve, Lemieux, Sebastien, Kauffman, Sarah, Becker, Jeff, Storms, Reginald, Boone, Charles, Bussey, Howard

“…Summary Candida albicans is the primary fungal pathogen of humans. Despite the need for novel drugs to combat fungal infections [Sobel, J.D. (2000) Clin…”
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Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase by Walker, Scott S, Labroli, Marc, Painter, Ronald E, Wiltsie, Judyann, Sherborne, Brad, Murgolo, Nicholas, Sher, Xinwei, Mann, Paul, Zuck, Paul, Garlisi, Charles G, Su, Jing, Kargman, Stacia, Xiao, Li, Scapin, Giovanna, Salowe, Scott, Devito, Kristine, Sheth, Payal, Buist, Nichole, Tan, Christopher M, Black, Todd A, Roemer, Terry

“…To combat the threat of antibiotic-resistant Gram-negative bacteria, novel agents that circumvent established resistance mechanisms are urgently needed. Our…”
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Chemical Genetic Profiling and Characterization of Small-molecule Compounds That Affect the Biosynthesis of Unsaturated Fatty Acids in Candida albicans by Xu, Deming, Sillaots, Susan, Davison, John, Hu, Wenqi, Jiang, Bo, Kauffman, Sarah, Martel, Nick, Ocampo, Pam, Oh, Chanseok, Trosok, Steve, Veillette, Karynn, Wang, Hao, Yang, Minghui, Zhang, Li, Becker, Jeffrey, Martin, Charles E., Roemer, Terry

“…The balance between saturated and unsaturated fatty acids plays a crucial role in determining the membrane fluidity. In the diploid fungal pathogen Candida…”
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Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis by Mann, Paul A, McLellan, Catherine A, Koseoglu, Sandra, Si, Qian, Kuzmin, Elena, Flattery, Amy, Harris, Guy, Sher, Xinwei, Murgolo, Nicholas, Wang, Hao, Devito, Kristine, de Pedro, Nuria, Genilloud, Olga, Kahn, Jennifer Nielsen, Jiang, Bo, Costanzo, Michael, Boone, Charlie, Garlisi, Charles G, Lindquist, Susan, Roemer, Terry

“…Steadily increasing antifungal drug resistance and persistent high rates of fungal-associated mortality highlight the dire need for the development of novel…”
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FtsZ-Dependent Elongation of a Coccoid Bacterium by Pereira, Ana R, Hsin, Jen, Król, Ewa, Tavares, Andreia C, Flores, Pierre, Hoiczyk, Egbert, Ng, Natalie, Dajkovic, Alex, Brun, Yves V, VanNieuwenhze, Michael S, Roemer, Terry, Carballido-Lopez, Rut, Scheffers, Dirk-Jan, Huang, Kerwyn Casey, Pinho, Mariana G

“…A mechanistic understanding of the determination and maintenance of the simplest bacterial cell shape, a sphere, remains elusive compared with that of more…”
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Isolation, Structure, and Biological Activities of Fellutamides C and D from an Undescribed Metulocladosporiella (Chaetothyriales) Using the Genome-Wide Candida albicans Fitness Test by Xu, Deming, Ondeyka, John, Harris, Guy H, Zink, Deborah, Kahn, Jennifer Nielsen, Wang, Hao, Bills, Gerald, Platas, Gonzalo, Wang, Wenxian, Szewczak, Alexander A, Liberator, Paul, Roemer, Terry, Singh, Sheo B

“…In a whole-cell mechanism of action (MOA)-based screening strategy for discovery of antifungal agents, Candida albicans was used, followed by testing of active…”
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