Search Results - "Roels, Frederik"

Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma by Brockmann, Markus, Poon, Evon, Berry, Teeara, Carstensen, Anne, Deubzer, Hedwig E., Rycak, Lukas, Jamin, Yann, Thway, Khin, Robinson, Simon P., Roels, Frederik, Witt, Olaf, Fischer, Matthias, Chesler, Louis, Eilers, Martin

“…Amplification of MYCN is a driver mutation in a subset of human neuroendocrine tumors, including neuroblastoma. No small molecules that target N-Myc, the…”
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Mutational dynamics between primary and relapse neuroblastomas by Schramm, Alexander, Köster, Johannes, Assenov, Yassen, Althoff, Kristina, Peifer, Martin, Mahlow, Ellen, Odersky, Andrea, Beisser, Daniela, Ernst, Corinna, Henssen, Anton G, Stephan, Harald, Schröder, Christopher, Heukamp, Lukas, Engesser, Anne, Kahlert, Yvonne, Theissen, Jessica, Hero, Barbara, Roels, Frederik, Altmüller, Janine, Nürnberg, Peter, Astrahantseff, Kathy, Gloeckner, Christian, De Preter, Katleen, Plass, Christoph, Lee, Sangkyun, Lode, Holger N, Henrich, Kai-Oliver, Gartlgruber, Moritz, Speleman, Frank, Schmezer, Peter, Westermann, Frank, Rahmann, Sven, Fischer, Matthias, Eggert, Angelika, Schulte, Johannes H

“…Alexander Schramm, Johannes Schulte and colleagues characterize 16 paired samples from patients with neuroblastoma at diagnosis and relapse using whole-exome…”
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Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma by Powers, John T., Tsanov, Kaloyan M., Pearson, Daniel S., Roels, Frederik, Spina, Catherine S., Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theißen, Jessica, Tu, Ho-Chou, Han, Areum, Kurek, Kyle C., LaPier, Grace S., Osborne, Jihan K., Ross, Samantha J., Cesana, Marcella, Collins, James J., Berthold, Frank, Daley, George Q.

“…Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN . MYCN is itself a target of let-7 , a tumour suppressor family of microRNAs…”
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Iodine-123 Metaiodobenzylguanidine Scintigraphy Scoring Allows Prediction of Outcome in Patients With Stage 4 Neuroblastoma: Results of the Cologne Interscore Comparison Study by DECAROLIS, Boris, SCHNEIDER, Christina, HERO, Barbara, SIMON, Thorsten, VOLLAND, Ruth, ROELS, Frederik, DIETLEIN, Markus, BERTHOLD, Frank, SCHMIDT, Matthias

“…Radioiodinated metaiodobenzylguanidine ((123)I-mIBG) scintigraphy is an established imaging method in neuroblastoma. Semiquantitative scoring systems have been…”
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Transcription factor activating protein 2 beta (TFAP2B) mediates noradrenergic neuronal differentiation in neuroblastoma by Ikram, Fakhera, Ackermann, Sandra, Kahlert, Yvonne, Volland, Ruth, Roels, Frederik, Engesser, Anne, Hertwig, Falk, Kocak, Hayriye, Hero, Barbara, Dreidax, Daniel, Henrich, Kai-Oliver, Berthold, Frank, Nürnberg, Peter, Westermann, Frank, Fischer, Matthias

“…Neuroblastoma is an embryonal pediatric tumor that originates from the developing sympathetic nervous system and shows a broad range of clinical behavior,…”
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FOXP1inhibits cell growth and attenuates tumorigenicity of neuroblastoma by Ackermann, Sandra, Kocak, Hayriye, Hero, Barbara, Ehemann, Volker, Kahlert, Yvonne, Oberthuer, André, Roels, Frederik, Theißen, Jessica, Odenthal, Margarete, Berthold, Frank, Fischer, Matthias

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Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles by Walz, Susanne, Lorenzin, Francesca, Morton, Jennifer, Wiese, Katrin E., von Eyss, Björn, Herold, Steffi, Rycak, Lukas, Dumay-Odelot, Hélène, Karim, Saadia, Bartkuhn, Marek, Roels, Frederik, Wüstefeld, Torsten, Fischer, Matthias, Teichmann, Martin, Zender, Lars, Wei, Chia-Lin, Sansom, Owen, Wolf, Elmar, Eilers, Martin

“…Inducing changes in the levels of the MYC oncoprotein is shown to activate and repress specific sets of target genes that are characteristic of tumour cells,…”
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Telomerase activation by genomic rearrangements in high-risk neuroblastoma by Peifer, Martin, Hertwig, Falk, Roels, Frederik, Dreidax, Daniel, Gartlgruber, Moritz, Menon, Roopika, Krämer, Andrea, Roncaioli, Justin L., Sand, Frederik, Heuckmann, Johannes M., Ikram, Fakhera, Schmidt, Rene, Ackermann, Sandra, Engesser, Anne, Kahlert, Yvonne, Vogel, Wenzel, Altmüller, Janine, Nürnberg, Peter, Thierry-Mieg, Jean, Thierry-Mieg, Danielle, Mariappan, Aruljothi, Heynck, Stefanie, Mariotti, Erika, Henrich, Kai-Oliver, Gloeckner, Christian, Bosco, Graziella, Leuschner, Ivo, Schweiger, Michal R., Savelyeva, Larissa, Watkins, Simon C., Shao, Chunxuan, Bell, Emma, Höfer, Thomas, Achter, Viktor, Lang, Ulrich, Theissen, Jessica, Volland, Ruth, Saadati, Maral, Eggert, Angelika, de Wilde, Bram, Berthold, Frank, Peng, Zhiyu, Zhao, Chen, Shi, Leming, Ortmann, Monika, Büttner, Reinhard, Perner, Sven, Hero, Barbara, Schramm, Alexander, Schulte, Johannes H., Herrmann, Carl, O’Sullivan, Roderick J., Westermann, Frank, Thomas, Roman K., Fischer, Matthias

“…Activation of telomere maintenance mechanisms—caused by novel somatic rearrangements of TERT , by MYCN amplification, or ATRX mutations—is a hallmark of…”
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Comparison of RNA-seq and microarray-based models for clinical endpoint prediction by Zhang, Wenqian, Yu, Ying, Hertwig, Falk, Thierry-Mieg, Jean, Zhang, Wenwei, Thierry-Mieg, Danielle, Wang, Jian, Furlanello, Cesare, Devanarayan, Viswanath, Cheng, Jie, Deng, Youping, Hero, Barbara, Hong, Huixiao, Jia, Meiwen, Li, Li, Lin, Simon M, Nikolsky, Yuri, Oberthuer, André, Qing, Tao, Su, Zhenqiang, Volland, Ruth, Wang, Charles, Wang, May D, Ai, Junmei, Albanese, Davide, Asgharzadeh, Shahab, Avigad, Smadar, Bao, Wenjun, Bessarabova, Marina, Brilliant, Murray H, Brors, Benedikt, Chierici, Marco, Chu, Tzu-Ming, Zhang, Jibin, Grundy, Richard G, He, Min Max, Hebbring, Scott, Kaufman, Howard L, Lababidi, Samir, Lancashire, Lee J, Li, Yan, Lu, Xin X, Luo, Heng, Ma, Xiwen, Ning, Baitang, Noguera, Rosa, Peifer, Martin, Phan, John H, Roels, Frederik, Rosswog, Carolina, Shao, Susan, Shen, Jie, Theissen, Jessica, Tonini, Gian Paolo, Vandesompele, Jo, Wu, Po-Yen, Xiao, Wenzhong, Xu, Joshua, Xu, Weihong, Xuan, Jiekun, Yang, Yong, Ye, Zhan, Dong, Zirui, Zhang, Ke K, Yin, Ye, Zhao, Chen, Zheng, Yuanting, Wolfinger, Russell D, Shi, Tieliu, Malkas, Linda H, Berthold, Frank, Wang, Jun, Tong, Weida, Shi, Leming, Peng, Zhiyu, Fischer, Matthias

“…Gene expression profiling is being widely applied in cancer research to identify biomarkers for clinical endpoint prediction. Since RNA-seq provides a powerful…”
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Multiple myeloma–related deregulation of bone marrow–derived CD34+ hematopoietic stem and progenitor cells by Bruns, Ingmar, Cadeddu, Ron-Patrick, Brueckmann, Ines, Fröbel, Julia, Geyh, Stefanie, Büst, Sebastian, Fischer, Johannes C., Roels, Frederik, Wilk, Christian Matthias, Schildberg, Frank A., Hünerlitürkoglu, Ali-Nuri, Zilkens, Christoph, Jäger, Marcus, Steidl, Ulrich, Zohren, Fabian, Fenk, Roland, Kobbe, Guido, Brors, Benedict, Czibere, Akos, Schroeder, Thomas, Trumpp, Andreas, Haas, Rainer

“…Multiple myeloma (MM) is a clonal plasma cell disorder frequently accompanied by hematopoietic impairment. We show that hematopoietic stem and progenitor cells…”
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Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma by Brockmann, Markus, Poon, Evon, Berry, Teeara, Carstensen, Anne, Deubzer, Hedwig E., Rycak, Lukas, Jamin, Yann, Thway, Khin, Robinson, Simon P., Roels, Frederik, Witt, Olaf, Fischer, Matthias, Chesler, Louis, Eilers, Martin

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GRHL1 Acts as Tumor Suppressor in Neuroblastoma and Is Negatively Regulated by MYCN and HDAC3 by FABIAN, Johannes, LODRINI, Marco, WIEGAND, Inga, MILDE, Till, MAHLKNECHT, Ulrich, WESTERMANN, Frank, POPANDA, Odilia, ROELS, Frederik, HERO, Barbara, BERTHOLD, Frank, FISCHER, Matthias, KULOZIK, Andreas E, OEHME, Ina, WITT, Olaf, DEUBZER, Hedwig E, SCHIER, Marie C, THOLE, Theresa M, HIELSCHER, Thomas, KOPP-SCHNEIDER, Annette, OPITZ, Lennart, CAPPER, David, VON DEIMLING, Andreas

“…Neuroblastoma is an embryonic solid tumor of neural crest origin and accounts for 11% of all cancer-related deaths in children. Novel therapeutic strategies…”
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FOXP1 inhibits cell growth and attenuates tumorigenicity of neuroblastoma by Ackermann, Sandra, Kocak, Hayriye, Hero, Barbara, Ehemann, Volker, Kahlert, Yvonne, Oberthuer, André, Roels, Frederik, Theißen, Jessica, Odenthal, Margarete, Berthold, Frank, Fischer, Matthias

“…Segmental genomic copy number alterations, such as loss of 11q or 3p and gain of 17q, are well established markers of poor outcome in neuroblastoma, and have…”
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Running Exercise in Obese Pregnancies Prevents IL-6 Trans-signaling in Male Offspring by BAE-GARTZ, INGA, JANOSCHEK, RUTH, KLOPPE, CORA-SOPHIA, VOHLEN, CHRISTINA, ROELS, FREDERIK, OBERTHÜR, ANDRE, ALEJANDRE ALCAZAR, MIGUEL ANGEL, LIPPACH, GREGOR, MUETHER, PHILIPP S, DINGER, KATHARINA, FERRARI, NINA, GRAF, CHRISTINE, DÖTSCH, JÖRG, HUCKLENBRUCH-ROTHER, EVA

“…PURPOSEMaternal obesity is known to predispose the offspring to impaired glucose metabolism and obesity associated with low-grade inflammation and hypothalamic…”
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AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis by Höpker, Katja, Hagmann, Henning, Khurshid, Safiya, Chen, Shuhua, Hasskamp, Pia, Seeger-Nukpezah, Tamina, Schilberg, Katharina, Heukamp, Lukas, Lamkemeyer, Tobias, Sos, Martin L, Thomas, Roman K, Lowery, Drew, Roels, Frederik, Fischer, Matthias, Liebau, Max C, Resch, Ulrike, Kisner, Tülay, Röther, Fabian, Bartram, Malte P, Müller, Roman Ulrich, Fabretti, Francesca, Kurschat, Peter, Schumacher, Björn, Gaestel, Matthias, Medema, René H, Yaffe, Michael B, Schermer, Bernhard, Reinhardt, H Christian, Benzing, Thomas

“…Following genotoxic stress, cells activate a complex signalling network to arrest the cell cycle and initiate DNA repair or apoptosis. The tumour suppressor…”
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Abstract LB-210: Telomerase activation by genomic rearrangements in high-risk neuroblastoma by Peifer, Martin, Roels, Frederik, Hertwig, Falk, Menon, Roopika, Kraemer, Andrea, Buettner, Reinhard, Perner, Sven, Schramm, Alexander, Schulte, Johannes H., Westermann, Frank, Thomas, Roman K., Fischer, Matthias

“…Abstract Neuroblastoma is a malignant pediatric tumor of the sympathetic nervous system. While roughly half of these tumors regress spontaneously or are cured…”
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Abstract LB-165: Multiple mechanisms disrupt let-7 miRNA biogenesis and function in neuroblastoma by Powers, John T., Tsanov, Kaloyan, Roels, Frederik, Spina, Catherine, Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Pearson, Daniel, Theißen, Jessica, Tu, Ho-Chou, LaPier, Grace, Osborne, Jihan, Ross, Samantha, Collins, James, Berthold, Frank, Daley, George

“…Abstract The let-7 microRNA family are known tumor suppressors often deregulated in cancer, yet the underlying mechanisms of let-7 disruption remain poorly…”
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γ-Secretase inhibitor I inhibits neuroblastoma cells, with NOTCH and the proteasome among its targets by Dorneburg, Carmen, Goß, Annika V, Fischer, Matthias, Roels, Frederik, Barth, Thomas F E, Berthold, Frank, Kappler, Roland, Oswald, Franz, Siveke, Jens T, Molenaar, Jan J, Debatin, Klaus-Michael, Beltinger, Christian

“…As high-risk neuroblastoma (NB) has a poor prognosis, new therapeutic modalities are needed. We therefore investigated the susceptibility of NB cells to…”
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Corrigendum: Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles by Walz, Susanne, Lorenzin, Francesca, Morton, Jennifer, Wiese, Katrin E, von Eyss, Bjorn, Herold, Steffi, Rycak, Lukas, Dumay-Odelot, Helene, Karim, Saadia, Bartkuhn, Marek, Roels, Frederik, Wustefeld, Torsten, Fischer, Matthias, Teichmann, Martin, Zender, Lars, Wei, Chia-Lin, Sansom, Owen, Wolf, Elmar, Eilers, Martin

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Correction: Corrigendum: Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles by Walz, Susanne, Lorenzin, Francesca, Morton, Jennifer, Wiese, Katrin E., von Eyss, Björn, Herold, Steffi, Rycak, Lukas, Dumay-Odelot, Hélène, Karim, Saadia, Bartkuhn, Marek, Roels, Frederik, Wüstefeld, Torsten, Fischer, Matthias, Teichmann, Martin, Zender, Lars, Wei, Chia-Lin, Sansom, Owen, Wolf, Elmar, Eilers, Martin

“…Nature 511, 483–487 (2014); doi:10.1038/nature13473 In this Letter, the ArrayExpress microarray data set accession number was wrongly given as E-MTAB-1524; the…”
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