Search Results - "Roelofs, E J"

Structural bisphenol analogues differentially target steroidogenesis in murine MA-10 Leydig cells as well as the glucocorticoid receptor by Roelofs, Maarke J.E, Berg, Martin van den, Bovee, Toine F.H, Piersma, Aldert H, Duursen, Majorie B.M.van

“…Abstract Although much information on the endocrine activity of bisphenol A (BPA) is available, a proper human hazard assessment of analogues that are believed…”
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The relevance of chemical interactions with CYP17 enzyme activity: Assessment using a novel in vitro assay by Roelofs, Maarke J.E., Piersma, Aldert H., van den Berg, Martin, van Duursen, Majorie B.M.

“…The steroidogenic cytochrome P450 17 (CYP17) enzyme produces dehydroepiandrosterone (DHEA), which is the most abundant circulating endogenous sex steroid…”
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Body Composition, Muscle Quality and Scoliosis in Female Collegiate Gymnasts: A Pilot Study by Trexler, E T, Smith-Ryan, A E, Roelofs, E J, Hirsch, K R

“…Research has demonstrated an elevated prevalence of body weight concerns and scoliosis among female gymnasts. The purpose of the current pilot study was to…”
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Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation by Hesselson, Stephanie E, Matsson, Pär, Shima, James E, Fukushima, Hisayo, Yee, Sook Wah, Kobayashi, Yuya, Gow, Jason M, Ha, Connie, Ma, Benjamin, Poon, Annie, Johns, Susan J, Stryke, Doug, Castro, Richard A, Tahara, Harunobu, Choi, Ji Ha, Chen, Ligong, Picard, Nicolas, Sjödin, Elin, Roelofs, Maarke J E, Ferrin, Thomas E, Myers, Richard, Kroetz, Deanna L, Kwok, Pui-Yan, Giacomini, Kathleen M

“…Membrane transporters play crucial roles in the cellular uptake and efflux of an array of small molecules including nutrients, environmental toxins, and many…”
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Endocrine disruptors differentially target ATP-binding cassette transporters in the blood-testis barrier and affect Leydig cell testosterone secretion in vitro by Dankers, Anita C A, Roelofs, Maarke J E, Piersma, Aldert H, Sweep, Fred C G J, Russel, Frans G M, van den Berg, Martin, van Duursen, Majorie B M, Masereeuw, Rosalinde

“…Endocrine-disrupting chemicals (EDCs) are considered to cause testicular toxicity primarily via interference with steroid hormone function. Alternatively, EDCs…”
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Evaluation of an alternative in vitro test battery for detecting reproductive toxicants by Piersma, A.H., Bosgra, S., van Duursen, M.B.M., Hermsen, S.A.B., Jonker, L.R.A., Kroese, E.D., van der Linden, S.C., Man, H., Roelofs, M.J.E., Schulpen, S.H.W., Schwarz, M., Uibel, F., van Vugt-Lussenburg, B.M.A., Westerhout, J., Wolterbeek, A.P.M., van der Burg, B.

“…•We tested 12 compounds in a battery of alternative reproductive and developmental toxicity tests.•The battery scored 11/12 compounds correctly, with one false…”
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Conazole fungicides inhibit Leydig cell testosterone secretion and androgen receptor activation in vitro by Roelofs, Maarke J E, Temming, A Roberto, Piersma, Aldert H, van den Berg, Martin, van Duursen, Majorie B M

“…Conazole fungicides are widely used in agriculture despite their suspected endocrine disrupting properties. In this study, the potential (anti-)androgenic…”
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Assuring safety without animal testing: The case for the human testis in vitro by Chapin, Robert E., Boekelheide, Kim, Cortvrindt, Rita, van Duursen, Majorie B.M., Gant, Tim, Jegou, Bernard, Marczylo, Emma, van Pelt, Ans M.M., Post, Janine N., Roelofs, Maarke J.E., Schlatt, Stefan, Teerds, Katja J., Toppari, Jorma, Piersma, Aldert H.

“…From 15 to 17 June 2011, a dedicated workshop was held on the subject of in vitro models for mammalian spermatogenesis and their applications in toxicological…”
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Pancreatic islet cell tumor producing vasoactive intestinal polypeptide and calcitonin by Eskens, F A, Roelofs, E J, Hermus, A R, Verhagen, C A

“…A patient with a pancreatic islet cell tumor concurrently producing vasoactive intestinal polypeptide (VIP) and calcitonin with related symptoms is presented…”
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Phase II study of sequential high-dose methotrexate (MTX) and 5-fluorouracil (F) alternated with epirubicin (E) and cisplatin (P) [FEMTX-P] in advanced gastric cancer by Roelofs, E J, Wagener, D J, Conroy, T, Wils, J, Burghouts, J T, Fickers, M, de Graeff, A, Lalisang, F, Paillot, B

“…FAMTX (5-fluorouracil, adriamycin, methotrexate) is one of the most effective drug combinations in gastric cancer. Therefore, modifications of FAMTX appear of…”
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Corrigendum to "Conazole fungicides inhibit Leydig cell testosterone secretion and androgen receptor activation in vitro " [Toxicol. Rep. 1C (2014) 271-283] by Roelofs, Maarke J E, Temming, A Roberto, Piersma, Aldert H, van den Berg, Martin, van Duursen, Majorie B M

“…[This corrects the article DOI: 10.1016/j.toxrep.2014.05.006.]…”
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Treatment of adrenal cortex carcinoma by Roelofs, E J, de Mulder, P H, Hermus, A R

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