Search Results - "Roeloffs, R"

N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator by Wickenden, A D, Krajewski, J L, London, B, Wagoner, P K, Wilson, W A, Clark, S, Roeloffs, R, McNaughton-Smith, G, Rigdon, G C

“…KCNQ2 (Kv7.2) and KCNQ3 (Kv7.3) are voltage-gated K(+) channel subunits that underlie the neuronal M current. In humans, mutations in these genes lead to a…”
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1083 Effect of RVT-502 therapy in the NC/Nga mouse model of atopic dermatitis by McHale, K., Harrington, W., Roeloffs, R., Lee, J.

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691 The effects of RVT-501 on DNCB-induced atopic dermatitis in NC/Nga mice by Roeloffs, R., Sampey, B., Lee, J., Rhodes, M., Soule, E.

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Dispersal and Population-Genetic Structure of the Cooperative Spider, Agelena consociata, in West African Rainforest by Roeloffs, Rosemarie, Riechert, Susan E.

“…Dispersal experiments and gel electrophoresis of allozyme polymorphisms were used to investigate the selective mode underlying cooperative behavior in the…”
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In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models by Roeloffs, Rosemarie, Wickenden, Alan D, Crean, Christopher, Werness, Stephen, McNaughton-Smith, Grant, Stables, James, McNamara, James O, Ghodadra, Neil, Rigdon, Greg C

“…Openers or activators of neuronal KCNQ2/Q3 potassium channels decrease neuronal excitability and may provide benefit in the treatment of disorders of neuronal…”
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Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain by Kort, Michael E, Drizin, Irene, Gregg, Robert J, Scanio, Marc J. C, Shi, Lei, Gross, Michael F, Atkinson, Robert N, Johnson, Matthew S, Pacofsky, Gregory J, Thomas, James B, Carroll, William A, Krambis, Michael J, Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Mikusa, Joseph P, Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Marsh, Kennan C, Murray, Bernard P, Liu, Jinrong, Werness, Stephen, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F, Chapman, Mark L, Marron, Brian E

“…Nav1.8 (also known as PN3) is a tetrodotoxin-resistant (TTx-r) voltage-gated sodium channel (VGSC) that is highly expressed on small diameter sensory neurons…”
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N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy by Amato, George, Roeloffs, Rosemarie, Rigdon, Greg C, Antonio, Brett, Mersch, Theresa, McNaughton-Smith, Grant, Wickenden, Alan D, Fritch, Paul, Suto, Mark J

“…A series of N-pyridyl benzamide KCNQ2/Q3 potassium channel openers were identified and found to be active in animal models of epilepsy and pain. The best…”
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The Effect of κ-Opioid Receptor Agonists on Tetrodotoxin-Resistant Sodium Channels in Primary Sensory Neurons by Su, Xin, Castle, Neil A., Antonio, Brett, Roeloffs, Rosemarie, Thomas, James B., Krafte, Douglas S., Chapman, Mark L.

“…A non-opioid receptor-mediated inhibition of sodium channels in dorsal root ganglia (DRGs) by kappa-opioid receptor agonists (kappa-ORAs) has been reported to…”
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The ecology of the cooperative spider Agelena consociata in Equatorial Africa (Araneae, Agelenidae) by Riechert, S.E, Roeloffs, R, Echternacht, A.C

“…The ecology of the spider Agelenopsis consociata in rain forest habitats in Gabon was investigated with reference to factors that might underlie its…”
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