Search Results - "Roelants, Caroline"

Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10 by Bouvard, Claire, Tu, Ly, Rossi, Martina, Desroches-Castan, Agnès, Berrebeh, Nihel, Helfer, Elise, Roelants, Caroline, Liu, Hequn, Ouarné, Marie, Chaumontel, Nicolas, Mallet, Christine, Battail, Christophe, Bikfalvi, Andreas, Humbert, Marc, Savale, Laurent, Daubon, Thomas, Perret, Pascale, Tillet, Emmanuelle, Guignabert, Christophe, Bailly, Sabine

“…Abstract Aims BMP9 and BMP10 mutations were recently identified in patients with pulmonary arterial hypertension, but their specific roles in the pathogenesis…”
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The size-speed-force relationship governs migratory cell response to tumorigenic factors by Leal-Egaña, Aldo, Letort, Gaelle, Martiel, Jean-Louis, Christ, Andreas, Vignaud, Timothée, Roelants, Caroline, Filhol, Odile, Théry, Manuel

“…Tumor development progresses through a complex path of biomechanical changes leading first to cell growth and contraction and then cell deadhesion, scattering,…”
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Protein kinase CK2 contributes to placental development: physiological and pathological implications by Abi Nahed, Roland, Reynaud, Deborah, Lemaitre, Nicolas, Lartigue, Solene, Roelants, Caroline, Vaiman, Daniel, Benharouga, Mohamed, Cochet, Claude, Filhol, Odile, Alfaidy, Nadia

“…Preeclampsia (PE) is the most threatening pathology of human pregnancy. Its development is thought to be due to a failure in the invasion of trophoblast cells…”
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Combined inhibition of PI3K and Src kinases demonstrates synergistic therapeutic efficacy in clear-cell renal carcinoma by Roelants, Caroline, Giacosa, Sofia, Pillet, Catherine, Bussat, Rémi, Champelovier, Pierre, Bastien, Olivier, Guyon, Laurent, Arnoux, Valentin, Cochet, Claude, Filhol, Odile

“…Potent inhibitors of PI3K (GDC-0941) and Src (Saracatinib) exhibit as individual agents, excellent oral anticancer activity in preclinical models and have…”
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Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket by Bancet, Alexandre, Frem, Rita, Jeanneret, Florian, Mularoni, Angélique, Bazelle, Pauline, Roelants, Caroline, Delcros, Jean-Guy, Guichou, Jean-François, Pillet, Catherine, Coste, Isabelle, Renno, Toufic, Battail, Christophe, Cochet, Claude, Lomberget, Thierry, Filhol, Odile, Krimm, Isabelle

“…Although the involvement of protein kinase CK2 in cancer is well-documented, there is a need for selective CK2 inhibitors suitable for investigating CK2…”
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BMP9 is a key player in endothelial identity and its loss is sufficient to induce arteriovenous malformations by Desroches-Castan, Agnes, Koca, Dzenis, Liu, Hequn, Roelants, Caroline, Resmini, Léa, Ricard, Nicolas, Bouvard, Claire, Chaumontel, Nicolas, Tharaux, Pierre-Louis, Tillet, Emmanuelle, Battail, Christophe, Lenoir, Olivia, Bailly, Sabine

“…BMP9 is a high affinity ligand of ALK1 and endoglin receptors that are mutated in the rare genetic vascular disorder hereditary hemorrhagic telangiectasia…”
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Ex-Vivo Treatment of Tumor Tissue Slices as a Predictive Preclinical Method to Evaluate Targeted Therapies for Patients with Renal Carcinoma by Roelants, Caroline, Pillet, Catherine, Franquet, Quentin, Sarrazin, Clément, Peilleron, Nicolas, Giacosa, Sofia, Guyon, Laurent, Fontanell, Amina, Fiard, Gaëlle, Long, Jean-Alexandre, Descotes, Jean-Luc, Cochet, Claude, Filhol, Odile

“…Clear cell renal cell carcinoma (ccRCC) is the third type of urologic cancer. At time of diagnosis, 30% of cases are metastatic with no effect of chemotherapy…”
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Targeting AU-rich element-mediated mRNA decay with a truncated active form of the zinc-finger protein TIS11b/BRF1 impairs major hallmarks of mammary tumorigenesis by Rataj, Felicitas, Planel, Séverine, Denis, Josiane, Roelants, Caroline, Filhol, Odile, Guyon, Laurent, Feige, Jean-Jacques, Cherradi, Nadia

“…Altered expression of regulatory RNA-binding proteins (RBPs) in cancer leads to abnormal expression of mRNAs encoding many factors involved in cancer…”
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Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10 by Bouvard, Claire, Tu, Ly, Rossi, Martina, Desroches-Castan, Agnès, Berrebeh, Nihel, Helfer, Elise, Roelants, Caroline, Liu, Hequn, Ouarné, Marie, Chaumontel, Nicolas, Mallet, Christine, Battail, Christophe, Bikfalvi, Andreas, Humbert, Marc, Savale, Laurent, Daubon, Thomas, Perret, Pascale, Tillet, Emmanuelle, Guignabert, Christophe, Bailly, Sabine

“…Aims BMP9 and BMP10 mutations were recently identified in patients with pulmonary arterial hypertension, but their specific roles in the pathogenesis of the…”
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The tyrosine-kinase inhibitor sunitinib targets vascular endothelial (VE)-cadherin: a marker of response to antitumoural treatment in metastatic renal cell carcinoma by Polena, Helena, Creuzet, Julie, Dufies, Maeva, Sidibé, Adama, Khalil-Mgharbel, Abir, Salomon, Aude, Deroux, Alban, Quesada, Jean-Louis, Roelants, Caroline, Filhol, Odile, Cochet, Claude, Blanc, Ellen, Ferlay-Segura, Céline, Borchiellini, Delphine, Ferrero, Jean-Marc, Escudier, Bernard, Négrier, Sylvie, Pages, Gilles, Vilgrain, Isabelle

“…Background Vascular endothelial (VE)-cadherin is an endothelial cell-specific protein responsible for endothelium integrity. Its adhesive properties are…”
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Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan sulfate chain that modulates its enzyme activity by El Masri, Rana, Seffouh, Amal, Roelants, Caroline, Seffouh, Ilham, Gout, Evelyne, Pérard, Julien, Dalonneau, Fabien, Nishitsuji, Kazuchika, Noborn, Fredrik, Nikpour, Mahnaz, Larson, Göran, Crétinon, Yoann, Friedel-Arboleas, Mélanie, Uchimura, Kenji, Daniel, Régis, Lortat-Jacob, Hugues, Filhol, Odile, Vivès, Romain R.

“…Sulfs represent a class of unconventional sulfatases which provide an original post-synthetic regulatory mechanism for heparan sulfate polysaccharides and are…”
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Correction: Combined inhibition of PI3K and Src kinases demonstrates synergistic therapeutic efficacy in clear-cell renal carcinoma by Caroline, Roelants, Sofia, Giacosa, Catherine, Pillet, Remi, Bussat, Pierre, Champelovier, Olivier, Bastien, Laurent, Guyon, Valentin, Arnoux, Claude, Cochet, Odile, Filhol

“…[This corrects the article DOI: 10.18632/oncotarget.25700.]…”
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Cooperative Blockade of CK2 and ATM Kinases Drives Apoptosis in VHL-Deficient Renal Carcinoma Cells through ROS Overproduction by Giacosa, Sofia, Pillet, Catherine, Séraudie, Irinka, Guyon, Laurent, Wallez, Yann, Roelants, Caroline, Battail, Christophe, Evrard, Bertrand, Chalmel, Frédéric, Barette, Caroline, Soleilhac, Emmanuelle, Fauvarque, Marie-Odile, Franquet, Quentin, Sarrazin, Clément, Peilleron, Nicolas, Fiard, Gaëlle, Long, Jean-Alexandre, Descotes, Jean-Luc, Cochet, Claude, Filhol, Odile

“…Kinase-targeted agents demonstrate antitumor activity in advanced metastatic clear cell renal cell carcinoma (ccRCC), which remains largely incurable…”
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