Search Results - "Roel, P."

Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly by De Maeyer, Roel P. H., van de Merwe, Rachel C., Louie, Rikah, Bracken, Olivia V., Devine, Oliver P., Goldstein, Daniel R., Uddin, Mohib, Akbar, Arne N., Gilroy, Derek W.

“…Increasing age alters innate immune–mediated responses; however, the mechanisms underpinning these changes in humans are not fully understood. Using a human…”
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Two-Dimensional Melting of Colloidal Hard Spheres by Thorneywork, Alice L, Abbott, Joshua L, Aarts, Dirk G A L, Dullens, Roel P A

“…We study the melting of quasi-two-dimensional colloidal hard spheres by considering a tilted monolayer of particles in sedimentation-diffusion equilibrium. In…”
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The impact of ageing on monocytes and macrophages by De Maeyer, Roel P.H., Chambers, Emma S.

“…•Chronic low-grade inflammation – inflammageing- is observed with age.•Macrophages and monocytes are central to the development of inflammageing.•In this…”
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Development of in vitro systems for nanotoxicology: methodological considerations by Stone, Vicki, Johnston, Helinor, Schins, Roel P. F.

“…Due to the rapid development of a diverse array of nanoparticles, used in a wide variety of products, there are now many international activities to assess the…”
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Towards Glasses with Permanent Stability by Yanagishima, Taiki, Russo, John, Dullens, Roel P. A., Tanaka, Hajime

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The role of senescent T cells in immunopathology by Covre, Luciana P., De Maeyer, Roel P. H., Gomes, Daniel C. O., Akbar, Arne N.

“…The development of senescence in tissues of different organs and in the immune system are usually investigated independently of each other although during…”
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Sestrins induce natural killer function in senescent-like CD8+ T cells by Pereira, Branca I., De Maeyer, Roel P. H., Covre, Luciana P., Nehar-Belaid, Djamel, Lanna, Alessio, Ward, Sophie, Marches, Radu, Chambers, Emma S., Gomes, Daniel C. O., Riddell, Natalie E., Maini, Mala K., Teixeira, Vitor H., Janes, Samuel M., Gilroy, Derek W., Larbi, Anis, Mabbott, Neil A., Ucar, Duygu, Kuchel, George A., Henson, Sian M., Strid, Jessica, Lee, Jun H., Banchereau, Jacques, Akbar, Arne N.

“…Aging is associated with remodeling of the immune system to enable the maintenance of life-long immunity. In the CD8 + T cell compartment, aging results in the…”
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Investigations of acute effects of polystyrene and polyvinyl chloride micro- and nanoplastics in an advanced in vitro triple culture model of the healthy and inflamed intestine by Busch, Mathias, Bredeck, Gerrit, Kämpfer, Angela A.M., Schins, Roel P.F.

“…The continuous degradation of plastic waste in the environment leads to the generation of micro- and nanoplastic fragments and particles. Due to the ubiquitous…”
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Evaluation of the Association Between Gastric Acid Suppression and Risk of Intestinal Colonization With Multidrug-Resistant Microorganisms: A Systematic Review and Meta-analysis by Willems, Roel P J, van Dijk, Karin, Ket, Johannes C F, Vandenbroucke-Grauls, Christina M J E

“…Acid suppressants inhibit gastric acid secretion and disrupt the intestinal microbiome. Whether acid suppression increases the risk of colonization with…”
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Distinctive Toxicity of TiO2 Rutile/Anatase Mixed Phase Nanoparticles on Caco-2 Cells by Gerloff, Kirsten, Fenoglio, Ivana, Carella, Emanuele, Kolling, Julia, Albrecht, Catrin, Boots, Agnes W, Förster, Irmgard, Schins, Roel P. F

“…Titanium dioxide has a long-standing use as a food additive. Micrometric powders are, e.g., applied as whiteners in confectionary or dairy products. Possible…”
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Superparamagnetic nickel colloidal nanocrystal clusters with antibacterial activity and bacteria binding ability by Peng, Bo, Zhang, Xinglin, Aarts, Dirk G. A. L., Dullens, Roel P. A.

“…Recent progress in synthetic nanotechnology and the ancient use of metals in food preservation and the antibacterial treatment of wounds have prompted the…”
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Advanced In Vitro Testing Strategies and Models of the Intestine for Nanosafety Research by Kämpfer, Angela A. M, Busch, Mathias, Schins, Roel P. F

“…There is growing concern about the potential adverse effects of oral exposure to engineered nanomaterials (ENM). Recent years have witnessed major developments…”
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Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease by Hullmann, Maja, Albrecht, Catrin, van Berlo, Damiën, Gerlofs-Nijland, Miriam E, Wahle, Tina, Boots, Agnes W, Krutmann, Jean, Cassee, Flemming R, Bayer, Thomas A, Schins, Roel P F

“…Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants…”
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Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): results from the 4-year open-label extension of the ORION-1 trial by Ray, Kausik K, Troquay, Roel P T, Visseren, Frank L J, Leiter, Lawrence A, Scott Wright, R, Vikarunnessa, Sheikh, Talloczy, Zsolt, Zang, Xiao, Maheux, Pierre, Lesogor, Anastasia, Landmesser, Ulf

“…Whether long-term treatment with the twice-yearly, siRNA therapeutic inclisiran, which reduces hepatic production of proprotein convertase subtilisin/kexin…”
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A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health-ENPRA Project-The Highlights, Limitations, and Current and Future Challenges by Kermanizadeh, Ali, Gosens, Ilse, MacCalman, Laura, Johnston, Helinor, Danielsen, Pernille H., Jacobsen, Nicklas R., Lenz, Anke-Gabriele, Fernandes, Teresa, Schins, Roel P. F., Cassee, Flemming R., Wallin, Håkan, Kreyling, Wolfgang, Stoeger, Tobias, Loft, Steffen, Møller, Peter, Tran, Lang, Stone, Vicki

“…ENPRA was one of the earlier multidisciplinary European Commission FP7-funded projects aiming to evaluate the risks associated with nanomaterial (NM) exposure…”
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Particle-Level Visualization of Hydrodynamic and Frictional Couplings in Dense Suspensions of Spherical Colloids by Yanagishima, Taiki, Liu, Yanyan, Tanaka, Hajime, Dullens, Roel P. A.

“…The rotational Brownian motion of colloidal spheres in dense suspensions reflects local hydrodynamics and contact forces, which are both key to nonlinear…”
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Temporal dynamics of gene expression in heat-stressed Caenorhabditis elegans by Jovic, Katharina, Sterken, Mark G, Grilli, Jacopo, Bevers, Roel P J, Rodriguez, Miriam, Riksen, Joost A G, Allesina, Stefano, Kammenga, Jan E, Snoek, L Basten

“…There is considerable insight into pathways and genes associated with heat-stress conditions. Most genes involved in stress response have been identified using…”
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CYP450-derived oxylipins mediate inflammatory resolution by Gilroy, Derek W., Edin, Matthew L., De Maeyer, Roel P. H., Bystrom, Jonas, Newson, Justine, Lih, Fred B., Stables, Melanie, Zeldin, Darryl C., Bishop-Bailey, David

“…Resolution of inflammation has emerged as an active process in immunobiology, with cells of the mononuclear phagocyte system being critical in mediating…”
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Saharan dust induces NLRP3-dependent inflammatory cytokines in an alveolar air-liquid interface co-culture model by Bredeck, Gerrit, Dobner, Jochen, Stahlmecke, Burkhard, Fomba, Khanneh Wadinga, Herrmann, Hartmut, Rossi, Andrea, Schins, Roel P F

“…Epidemiological studies have related desert dust events to increased respiratory morbidity and mortality. Although the Sahara is the largest source of desert…”
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Human Neutrophils Use Different Mechanisms To Kill Aspergillus fumigatus Conidia and Hyphae: Evidence from Phagocyte Defects by Gazendam, Roel P, van Hamme, John L, Tool, Anton T J, Hoogenboezem, Mark, van den Berg, J Merlijn, Prins, Jan M, Vitkov, Ljubomir, van de Veerdonk, Frank L, van den Berg, Timo K, Roos, Dirk, Kuijpers, Taco W

“…Neutrophils are known to play a pivotal role in the host defense against Aspergillus infections. This is illustrated by the prevalence of Aspergillus…”
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