Search Results - "Roel, G."

Extrachromosomal oncogene amplification in tumour pathogenesis and evolution by Verhaak, Roel G. W., Bafna, Vineet, Mischel, Paul S.

“…Recent reports have demonstrated that oncogene amplification on extrachromosomal DNA (ecDNA) is a frequent event in cancer, providing new momentum to explore a…”
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Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy by Gong, Ying, Klein Wolterink, Roel G J, Wang, Jianxiang, Bos, Gerard M J, Germeraad, Wilfred T V

“…Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are considered as specialized immune cells that can be genetically…”
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Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas by Campbell, Joshua D, Alexandrov, Anton, Kim, Jaegil, Wala, Jeremiah, Berger, Alice H, Pedamallu, Chandra Sekhar, Shukla, Sachet A, Guo, Guangwu, Brooks, Angela N, Murray, Bradley A, Imielinski, Marcin, Hu, Xin, Ling, Shiyun, Akbani, Rehan, Rosenberg, Mara, Cibulskis, Carrie, Ramachandran, Aruna, Collisson, Eric A, Kwiatkowski, David J, Lawrence, Michael S, Weinstein, John N, Verhaak, Roel G W, Wu, Catherine J, Hammerman, Peter S, Cherniack, Andrew D, Getz, Gad, Artyomov, Maxim N, Schreiber, Robert, Govindan, Ramaswamy, Meyerson, Matthew

“…Matthew Meyerson, Ramaswamy Govindan and colleagues examine the exome sequences and copy number profiles of 660 lung adenocarcinoma and 484 lung squamous cell…”
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Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587 by Figueroa, Javier, Phillips, Lynette M, Shahar, Tal, Hossain, Anwar, Gumin, Joy, Kim, Hoon, Bean, Andrew J, Calin, George A, Fueyo, Juan, Walters, Edgar T, Kalluri, Raghu, Verhaak, Roel G, Lang, Frederick F

“…Tumor-stromal communications impact tumorigenesis in ways that are incompletely understood. Here, we show that glioma-associated human mesenchymal stem cells…”
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MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas by Oldrini, Barbara, Vaquero-Siguero, Nuria, Mu, Quanhua, Kroon, Paula, Zhang, Ying, Galán-Ganga, Marcos, Bao, Zhaoshi, Wang, Zheng, Liu, Hanjie, Sa, Jason K., Zhao, Junfei, Kim, Hoon, Rodriguez-Perales, Sandra, Nam, Do-Hyun, Verhaak, Roel G. W., Rabadan, Raul, Jiang, Tao, Wang, Jiguang, Squatrito, Massimo

“…Temozolomide (TMZ) is an oral alkylating agent used for the treatment of glioblastoma and is now becoming a chemotherapeutic option in patients diagnosed with…”
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Circular ecDNA promotes accessible chromatin and high oncogene expression by Wu, Sihan, Turner, Kristen M., Nguyen, Nam, Raviram, Ramya, Erb, Marcella, Santini, Jennifer, Luebeck, Jens, Rajkumar, Utkrisht, Diao, Yarui, Li, Bin, Zhang, Wenjing, Jameson, Nathan, Corces, M. Ryan, Granja, Jeffrey M., Chen, Xingqi, Coruh, Ceyda, Abnousi, Armen, Houston, Jack, Ye, Zhen, Hu, Rong, Yu, Miao, Kim, Hoon, Law, Julie A., Verhaak, Roel G. W., Hu, Ming, Furnari, Frank B., Chang, Howard Y., Ren, Bing, Bafna, Vineet, Mischel, Paul S.

“…Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in cancer 1 , 2 , but our understanding of the structure of ecDNA and its effect…”
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Reconstructing the molecular life history of gliomas by Barthel, Floris P., Wesseling, Pieter, Verhaak, Roel G. W.

“…At the time of their clinical manifestation, the heterogeneous group of adult and pediatric gliomas carries a wide range of diverse somatic genomic…”
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Extrachromosomal DNA amplifications in cancer by Yi, Eunhee, Chamorro González, Rocío, Henssen, Anton G., Verhaak, Roel G. W.

“…Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It has been observed in most cancer types and is associated with worse…”
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EGFR heterogeneity and implications for therapeutic intervention in glioblastoma by Eskilsson, Eskil, Røsland, Gro V, Solecki, Gergely, Wang, Qianghu, Harter, Patrick N, Graziani, Grazia, Verhaak, Roel G W, Winkler, Frank, Bjerkvig, Rolf, Miletic, Hrvoje

“…Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need of effective treatment strategies. Recent advances in sequencing…”
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Pulmonary innate lymphoid cells are major producers of IL‐5 and IL‐13 in murine models of allergic asthma by Wolterink, Roel G. J. Klein, KleinJan, Alex, van Nimwegen, Menno, Bergen, Ingrid, de Bruijn, Marjolein, Levani, Yelvi, Hendriks, Rudi W.

“…Allergic asthma is characterized by chronic airway inflammation and hyperreactivity and is thought to be mediated by an adaptive T helper‐2 (Th2) cell‐type…”
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Neuro-mesenchymal units control ILC2 and obesity via a brain–adipose circuit by Cardoso, Ana, Klein Wolterink, Roel G. J., Godinho-Silva, Cristina, Domingues, Rita G., Ribeiro, Hélder Manuel, da Silva, Joaquim Alves, Mahú, Inês, Domingos, Ana I., Veiga Fernandes, Henrique

“…Copyright © 2021, The Author(s), under exclusive licence to Springer Nature Limited Signals from sympathetic neurons and immune cells regulate adipocytes and…”
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TumorFusions: an integrative resource for cancer-associated transcript fusions by Hu, Xin, Wang, Qianghu, Tang, Ming, Barthel, Floris, Amin, Samirkumar, Yoshihara, Kosuke, Lang, Frederick M, Martinez-Ledesma, Emmanuel, Lee, Soo Hyun, Zheng, Siyuan, Verhaak, Roel G W

“…Abstract Gene fusion represents a class of molecular aberrations in cancer and has been exploited for therapeutic purposes. In this paper we describe…”
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Systematic analysis of telomere length and somatic alterations in 31 cancer types by Barthel, Floris P, Wei, Wei, Tang, Ming, Martinez-Ledesma, Emmanuel, Hu, Xin, Amin, Samirkumar B, Akdemir, Kadir C, Seth, Sahil, Song, Xingzhi, Wang, Qianghu, Lichtenberg, Tara, Hu, Jian, Zhang, Jianhua, Zheng, Siyuan, Verhaak, Roel G W

“…Siyuan Zheng, Roel Verhaak and colleagues report an analysis of telomere lengths and somatic alterations in telomere-related pathways across 31 cancer types…”
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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation by Koivunen, Peppi, Lee, Sungwoo, Duncan, Christopher G., Lopez, Giselle, Lu, Gang, Ramkissoon, Shakti, Losman, Julie A., Joensuu, Päivi, Bergmann, Ulrich, Gross, Stefan, Travins, Jeremy, Weiss, Samuel, Looper, Ryan, Ligon, Keith L., Verhaak, Roel G. W., Yan, Hai, Kaelin Jr, William G.

“…The ( R )-enantiomer of 2-hydroxyglutarate, which is produced when IDH is mutated in human tumours, is shown to stimulate the activity of the EGLN prolyl…”
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Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions by Wen, Patrick Y, Weller, Michael, Lee, Eudocia Quant, Alexander, Brian M, Barnholtz-Sloan, Jill S, Barthel, Floris P, Batchelor, Tracy T, Bindra, Ranjit S, Chang, Susan M, Chiocca, E Antonio, Cloughesy, Timothy F, DeGroot, John F, Galanis, Evanthia, Gilbert, Mark R, Hegi, Monika E, Horbinski, Craig, Huang, Raymond Y, Lassman, Andrew B, Le Rhun, Emilie, Lim, Michael, Mehta, Minesh P, Mellinghoff, Ingo K, Minniti, Giuseppe, Nathanson, David, Platten, Michael, Preusser, Matthias, Roth, Patrick, Sanson, Marc, Schiff, David, Short, Susan C, Taphoorn, Martin J B, Tonn, Joerg-Christian, Tsang, Jonathan, Verhaak, Roel G W, von Deimling, Andreas, Wick, Wolfgang, Zadeh, Gelareh, Reardon, David A, Aldape, Kenneth D, van den Bent, Martin J

“…Abstract Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have…”
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Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5⁺ and IL-13⁺ type 2 innate lymphoid cells by Wolterink, Roel G. J. Klein, Serafini, Nicolas, van Nimwegen, Menno, Vosshenrich, Christian A. J., de Bruijn, Marjolein J. W., Pereira, Diogo Fonseca, Fernandes, Henrique Veiga, Hendriks, Rudi W., Di Santo, James P.

“…Group 2 innate lymphoid cells (ILC2s; also called nuocytes, innate helper cells, or natural helper cells) provide protective immunity during helminth infection…”
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GlioVis data portal for visualization and analysis of brain tumor expression datasets by Bowman, Robert L, Wang, Qianghu, Carro, Angel, Verhaak, Roel G W, Squatrito, Massimo

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Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma by deCarvalho, Ana C., Kim, Hoon, Poisson, Laila M., Winn, Mary E., Mueller, Claudius, Cherba, David, Koeman, Julie, Seth, Sahil, Protopopov, Alexei, Felicella, Michelle, Zheng, Siyuan, Multani, Asha, Jiang, Yongying, Zhang, Jianhua, Nam, Do-Hyun, Petricoin, Emanuel F., Chin, Lynda, Mikkelsen, Tom, Verhaak, Roel G. W.

“…To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the…”
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Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma by Sa, Jason K, Chang, Nakho, Lee, Hye Won, Cho, Hee Jin, Ceccarelli, Michele, Cerulo, Luigi, Yin, Jinlong, Kim, Sung Soo, Caruso, Francesca P, Lee, Mijeong, Kim, Donggeon, Oh, Young Taek, Lee, Yeri, Her, Nam-Gu, Min, Byeongkwi, Kim, Hye-Jin, Jeong, Da Eun, Kim, Hye-Mi, Kim, Hyunho, Chung, Seok, Woo, Hyun Goo, Lee, Jeongwu, Kong, Doo-Sik, Seol, Ho Jun, Lee, Jung-Il, Kim, Jinho, Park, Woong-Yang, Wang, Qianghu, Sulman, Erik P, Heimberger, Amy B, Lim, Michael, Park, Jong Bae, Iavarone, Antonio, Verhaak, Roel G W, Nam, Do-Hyun

“…Glioblastoma (GBM) is a complex disease with extensive molecular and transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes;…”
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Perspective of mesenchymal transformation in glioblastoma by Kim, Yona, Varn, Frederick S, Park, Sung-Hye, Yoon, Byung Woo, Park, Hye Ran, Lee, Charles, Verhaak, Roel G W, Paek, Sun Ha

“…Despite aggressive multimodal treatment, glioblastoma (GBM), a grade IV primary brain tumor, still portends a poor prognosis with a median overall survival of…”
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