Search Results - "Roedig, Heiko"

Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy by Roedig, Heiko, Nastase, Madalina Viviana, Wygrecka, Malgorzata, Schaefer, Liliana

“…It is well established that biglycan, a small leucine‐rich proteoglycan, acts as an extracellular matrix‐derived danger signal in its soluble form. By binding…”
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Biglycan is a new high-affinity ligand for CD14 in macrophages by Roedig, Heiko, Nastase, Madalina V., Frey, Helena, Moreth, Kristin, Zeng-Brouwers, Jinyang, Poluzzi, Chiara, Hsieh, Louise Tzung-Harn, Brandts, Christian, Fulda, Simone, Wygrecka, Malgorzata, Schaefer, Liliana

“…Sterile inflammation is a therapeutic target in many diseases where it represents an important initiator of disease progression. However, the detailed…”
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Affinity Proteomics Identifies Interaction Partners and Defines Novel Insights into the Function of the Adhesion GPCR VLGR1/ADGRV1 by Knapp, Barbara, Roedig, Jens, Roedig, Heiko, Krzysko, Jacek, Horn, Nicola, Güler, Baran E, Kusuluri, Deva Krupakar, Yildirim, Adem, Boldt, Karsten, Ueffing, Marius, Liebscher, Ines, Wolfrum, Uwe

“…The very large G-protein-coupled receptor 1 (VLGR1/ADGRV1) is the largest member of the adhesion G-protein-coupled receptor (ADGR) family. Mutations in…”
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Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants by Hsieh, Louise Tzung-Harn, Nastase, Madalina-Viviana, Roedig, Heiko, Zeng-Brouwers, Jinyang, Poluzzi, Chiara, Schwalm, Stephanie, Fork, Christian, Tredup, Claudia, Brandes, Ralf P, Wygrecka, Malgorzata, Huwiler, Andrea, Pfeilschifter, Josef, Schaefer, Liliana

“…In its soluble form, the extracellular matrix proteoglycan biglycan triggers the synthesis of the macrophage chemoattractants, chemokine (C-C motif) ligand…”
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Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development by Roedig, Heiko, Damiescu, Roxana, Zeng-Brouwers, Jinyang, Kutija, Iva, Trebicka, Jonel, Wygrecka, Malgorzata, Schaefer, Liliana

“…The tumor matrix together with inflammation and autophagy are crucial regulators of cancer development. Embedded in the tumor stroma are numerous proteoglycans…”
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USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination by Roedig, Jens, Kowald, Lisa, Juretschke, Thomas, Karlowitz, Rebekka, Ahangarian Abhari, Behnaz, Roedig, Heiko, Fulda, Simone, Beli, Petra, van Wijk, Sjoerd JL

“…Dynamic control of ubiquitination by deubiquitinating enzymes is essential for almost all biological processes. Ubiquitin-specific peptidase 22 (USP22) is part…”
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Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury by Poluzzi, Chiara, Nastase, Madalina-Viviana, Zeng-Brouwers, Jinyang, Roedig, Heiko, Hsieh, Louise Tzung-Harn, Michaelis, Jonas B, Buhl, Eva Miriam, Rezende, Flavia, Manavski, Yosif, Bleich, André, Boor, Peter, Brandes, Ralf P, Pfeilschifter, Josef, Stelzer, Ernst H K, Münch, Christian, Dikic, Ivan, Brandts, Christian, Iozzo, Renato V, Wygrecka, Malgorzata, Schaefer, Liliana

“…Biglycan, a small leucine-rich proteoglycan, acts as a danger signal and is classically thought to promote macrophage recruitment via Toll-like receptors (TLR)…”
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A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1): a novel modulator of mitochondrial autophagy by Merline, Rosetta, Rödig, Heiko, Zeng-Brouwers, Jinyang, Poluzzi, Chiara, Tascher, Georg, Michaelis, Jonas, Lopez-Mosqueda, Jaime, Rhiner, Andrew, Huber, Lisa Sophie, Diehl, Valentina, Dikic, Ivan, Kögel, Donat, Münch, Christian, Wygrecka, Malgorzata, Schaefer, Liliana

“…A20 binding inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1), a polyubiquitin-binding protein, is a signal-induced autophagy receptor that attenuates…”
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Small Leucine-Rich Proteoglycans in Renal Inflammation: Two Sides of the Coin by Nastase, Madalina V., Janicova, Andrea, Roedig, Heiko, Hsieh, Louise Tzung-Harn, Wygrecka, Malgorzata, Schaefer, Liliana

“…It is now well-established that members of the small leucine-rich proteoglycan (SLRP) family act in their soluble form, released proteolytically from the…”
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