Search Results - "Roedel, F."

Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16 18-infected cancer cells by Kreis, N N, Sanhaji, M, Krämer, A, Sommer, K, Rödel, F, Strebhardt, K, Yuan, J

“…Abrogation of functional p53 is responsible for malignant cell transformation and the maintenance of malignant state of human papillomavirus-infected cancer…”
Get full text

Anti-inflammatory effect of low-dose X-irradiation and the involvement of a TGF-β1-induced down-regulation of leukocyte/endothelial cell adhesion by ROEDEL, F, KLEY, N, BEUSCHER, H. U, HILDEBRANDT, G, KEILHOLZ, L, KERN, P, VOLL, R, HERRMANN, M, SAUER, R

Get full text

Whole body low dose irradiation improves the course of beginning polyarthritis in human TNF-transgenic mice by Frey, B., Gaipl, U. S., Sarter, K., Zaiss, M. M., Stillkrieg, W., Rödel, F., Schett, G., Herrmann, M., Fietkau, R., Keilholz, L.

“…Rheumatoid arthritis (RA) displays a chronic inflammatory joint disease, accompanied by symmetric polyarthritis (PA) which evokes synovial inflammation,…”
Get full text

Activation-induced cell death and total Akt content of granulocytes show a biphasic course after low-dose radiation by Gaipl, U. S., Meister, S., Lödermann, B., Rödel, F., Fietkau, R., Herrmann, M., Kern, P. M., Frey, B.

“…Low-dose radiation (single doses from 0.3 to 1.0 Gy) in clinical practice is mostly used to treat patients with several inflammatory diseases and painful…”
Get full text

Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer by Balermpas, P, Michel, Y, Wagenblast, J, Seitz, O, Weiss, C, Rödel, F, Rödel, C, Fokas, E

“…Background: We aimed to investigate the prognostic value of tumour-infiltrating lymphocytes’ (TILs) expression in pretreatment specimens from patients with…”
Get full text

Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti‐inflammatory cytokine milieu, but do not impact upon viability and phagocytic function by Wunderlich, R., Ernst, A., Rödel, F., Fietkau, R., Ott, O., Lauber, K., Frey, B., Gaipl, U. S.

“…Summary Benign painful and inflammatory diseases have been treated for decades with low/moderate doses of ionizing radiation (LD‐X‐irradiation). Tissue…”
Get full text

Advances in molecular targeted therapies to increase efficacy of (chemo)radiation therapy by Viktorsson, Kristina, Rieckmann, Thorsten, Fleischmann, Maximilian, Diefenhardt, Markus, Hehlgans, Stephanie, Rödel, Franz

“…Recent advances in understanding the tumor’s biology in line with a constantly growing number of innovative technologies have prompted characterization of…”
Get full text

Head and neck cancer relapse after chemoradiotherapy correlates with CD163+ macrophages in primary tumour and CD11b+ myeloid cells in recurrences by Balermpas, P, Rödel, F, Liberz, R, Oppermann, J, Wagenblast, J, Ghanaati, S, Harter, P N, Mittelbronn, M, Weiss, C, Rödel, C, Fokas, E

“…Background: We investigated the prognostic role of tumour-associated macrophages (TAMs) in patients with head and neck squamous cell carcinoma (HNSCC) treated…”
Get full text

Modulation of inflammatory immune reactions by low-dose ionizing radiation: molecular mechanisms and clinical application by Rödel, F, Frey, B, Gaipl, U, Keilholz, L, Fournier, C, Manda, K, Schöllnberger, H, Hildebrandt, G, Rödel, C

“…During the last decade, a multitude of experimental evidence has accumulated showing that low-dose radiation therapy (single dose 0.5-1 Gy) functionally…”
Get more information

Survivin as a prognostic/predictive marker and molecular target in cancer therapy by Rödel, F, Sprenger, T, Kaina, B, Liersch, T, Rödel, C, Fulda, S, Hehlgans, S

“…Evasion from apoptotic cell death is reported to be a pivotal mechanism by which tumor cells acquire resistance to therapeutic treatment. Targeting the…”
Get more information

Radiobiological mechanisms in inflammatory diseases of low-dose radiation therapy by Rödel, F., Keilholz, L., Herrmann, M., Sauer, R., Hildebrandt, G.

“…Purpose: Whereas X-irradiation with high doses is established to exert pro-inflammatory effects, low-dose radiotherapy (LD-RT) with single fractions below 1.0…”
Get full text

Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells by Michaelis, M, Rothweiler, F, Barth, S, Cinatl, J, van Rikxoort, M, Löschmann, N, Voges, Y, Breitling, R, von Deimling, A, Rödel, F, Weber, K, Fehse, B, Mack, E, Stiewe, T, Doerr, H W, Speidel, D, Cinatl, J

“…Six p53 wild-type cancer cell lines from infrequently p53-mutated entities (neuroblastoma, rhabdomyosarcoma, and melanoma) were continuously exposed to…”
Get full text

Inflammatory pathways confer resistance to chemoradiotherapy in anal squamous cell carcinoma by Martin, D., Rödel, F., Hehlgans, S., Looso, M., Ziegler, P. K., Fleischmann, M., Diefenhardt, M., Fries, L., Kalinauskaite, G., Tinhofer, I., Zips, D., Gani, C., Rödel, C., Fokas, E.

“…Anal squamous cell carcinoma (ASCC) is associated with immunosuppression and infection with human papillomavirus (HPV). Response to standard chemoradiotherapy…”
Get full text

The role of survivin for radiation oncology: moving beyond apoptosis inhibition by Rödel, F, Reichert, S, Sprenger, T, Gaipl, U S, Mirsch, J, Liersch, T, Fulda, S, Rödel, C

“…Alterations in the expression of apoptosis-related proteins, like the inhibitor of apoptosis (IAP) protein family, display a pivotal pathway by which cancer…”
Get more information

The Tumor Gene Survivin Is Highly Expressed in Adult Renal Tubular Cells: Implications for a Pathophysiological Role in the Kidney by Lechler, Philipp, Wu, Xiaoqing, Bernhardt, Wanja, Campean, Valentina, Gastiger, Susanne, Hackenbeck, Thomas, Klanke, Bernd, Weidemann, Alexander, Warnecke, Christina, Amann, Kerstin, Engehausen, Dirk, Willam, Carsten, Eckardt, Kai-Uwe, Rodel, Franz, Wiesener, Michael Sean

“…The inhibitor of apoptosis protein survivin is of critical importance for regulation of cellular division and survival. Published data point to a restricted…”
Get full text

EGFR, PTEN, and survivin expression in pre- and posttherapeutic specimens does not predict a clinical benefit from preoperative chemoradiation with cetuximab in patients (pts) with locally advanced rectal cancer (LARC) by Dellas, K., Roedel, F., Arnold, D., Kappler, M., Hipp, M., Bataille, F., Vordermark, D., Roedel, C., Hartmann, A.

“…Abstract only…”
Get full text

Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents by Michaelis, M, Rothweiler, F, Agha, B, Barth, S, Voges, Y, Löschmann, N, von Deimling, A, Breitling, R, Wilhelm Doerr, H, Rödel, F, Speidel, D, Cinatl, J

“…Adaptation of wild-type p53 expressing UKF-NB-3 cancer cells to the murine double minute 2 inhibitor nutlin-3 causes de novo p53 mutations at high frequency…”
Get full text

Differences in the Gene Expression Profile of Matrix Metalloproteinases (MMPs) and their Inhibitors (TIMPs) in Primary Colorectal Tumors and their Synchronous Liver Metastases by GENTNER, Bernhard, WEIN, Axel, BRUECKL, Wolfgang M, CRONER, Roland S, ZEITTRAEGER, Isabel, WIRTZ, Ralph M, ROEDEL, Franz, DIMMLER, Arno, DORLAQUE, Laure, HOHENBERGER, Werner, HAHN, Eckhart G

“…Background: Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been strongly implicated in the pathogenesis of many types of human…”
Get full text

Activator protein 1 shows a biphasic induction and transcriptional activity after low dose X-irradiation in EA.hy.926 endothelial cells by Rödel, Franz, Keilholz, Ludwig, Herrmann, Martin, Weiss, Christian, Frey, Benjamin, Voll, Reinhard, Gaipl, Udo, Rödel, Claus

“…Low dose radiotherapy (LD-RT) is known to exert an anti-inflammatory effect. The underlying molecular mechanisms, however, are still a matter of actual…”
Get full text

Sensitive detection of plasma/serum DNA in patients with systemic lupus erythematosus by Chen, Justin A., Meister, Silke, Urbonaviciute, Vilma, Rödel, Franz, Wilhelm, Sabine, Kalden, Joachim R., Manger, Karin, Voll, Reinhard E.

“…Objective: To optimize the use of the fluorochromic PicoGreen assay for the sensitive detection and quantification of double stranded (ds) DNA in plasma/serum…”
Get full text