Search Results - "Roebroek, A J"

Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis by CREEMERS, J. W. M, SIEZEN, R. J, ROEBROEK, A. J. M, AYOUBI, T. A. Y, HUYLEBROECK, D, VAN DE VEN, W. J. M

“…The proprotein processing activity of mutants of the subtilisin-like enzyme furin was studied in transfected mammalian cells. Our studies indicate that the…”
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A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas by MEERABUX, J, YASPO, M.-L, ROEBROEK, A. J, VAN DE VEN, W. J. M, LISTER, T. A, YOUNG, B. D

“…A new member of the proprotein convertase gene family (LPC) has been identified at a chromosome translocation breakpoint occurring in a high grade lymphoma…”
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NSP-encoded reticulons, neuroendocrine proteins of a novel gene family associated with membranes of the endoplasmic reticulum by VAN DE VELDE, H. J. K, ROEBROEK, A. J. M, SENDEN, N. H. M, RAMAEKERS, F. C. S, VAN DE VEN, W. J. M

“…The novel NSP gene was previously shown to encode, among a variety of neuroendocrine cell types, two 3'-overlapping transcripts, a 3.4 kb one for NSP-A (776…”
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Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product by ROEBROEK, A. J. M, VAN DE VELDE, H. J. K, VAN BOKHOVEN, A, BROERS, J. L. V, RAMAEKERS, F. C. S, VAN DE VEN, W. J. M

“…Monoclonal antibodies RNL-2 and RNL-3 were previously shown to react with four 35-45-kDa proteins, expressed only in small cell lung carcinoma NCI-H82 cells,…”
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Expression of the dibasic proprotein processing enzyme furin is directed by multiple promoters by AYOUBI, T. A. Y, CREEMERS, J. W. M, ROEBROEK, A. J. M, VAN DE VEN, W. J. M

“…The prototype mammalian proprotein processing enzyme furin is shown to be encoded by three distinct FUR mRNA isoforms which differ only in their…”
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Evolutionary conserved close linkage of the c‐fes/fps proto‐oncogene and genetic sequences encoding a receptor‐like protein by Roebroek, A.J., Schalken, J.A., Leunissen, J.A., Onnekink, C., Bloemers, H.P., Van de Ven, W.J.

“…Recently we described that genetic sequences in the immediately upstream region of the c‐fes/fps proto‐oncogene, designated fur, constituted a transcription…”
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Analysis of a cDNA Clone Expressing a Human Autoimmune Antigen: Full-Length Sequence of the U2 Small Nuclear RNA-Associated B′ ′Antigen by Habets, Winand J., Peter T. G. Sillekens, Hoet, Margot H., Schalken, Jack A., Anton J. M. Roebroek, Jack A. M. Leunissen, Wim J. M. Van De Ven, Van Venrooij, Walther J.

“…A U2 small nuclear RNA-associated protein, designated B′ ′, was recently identified as the target antigen for autoimmune sera from certain patients with…”
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Furin-mediated proprotein processing activity: involvement of negatively charged amino acid residues in the substrate binding region by Roebroek, A J, Creemers, J W, Ayoubi, T A, Van de Ven, W J

“…Furin, which is encoded by the recently discovered FUR gene, appears to be the first known mammalian member of the subtilisin family of serine proteases with…”
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The structure of the human c‐fes/fps proto‐oncogene by Roebroek, A.J., Schalken, J.A., Verbeek, J.S., Van den Ouweland, A.M., Onnekink, C., Bloemers, H.P., Van de Ven, W.J.

“…We have determined the complete nucleotide sequence of a human DNA fragment of approximately 13 kbp, which was shown by Southern blot analysis to contain the…”
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cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons by ROEBROEK, A. J. M, CONTRERAS, B, PAULI, I. G. L, VAN DE VEN, W. J. M

“…This paper describes the cDNA cloning, genomic organization, and expression of the human RTN2 gene on chromosome 19q13.3, which was recognized by virtue of its…”
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Assignment of the human proprotein convertase gene PCSK5 to chromosome 9q21.3 by van de Loo, J W, Creemers, J W, Kas, K, Roebroek, A J, Van de Ven, W J

“…The human PCSK5 gene, which encodes a subtilisin-like proprotein processing enzyme, has been mapped by analysis of somatic cell hybrids and YAC clones as well…”
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Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases by Van de Ven, W J, Roebroek, A J, Van Duijnhoven, H L

“…Production of a broad spectrum of regulatory proteins in eukaryotes occurs via an intricate cascade of biosynthetic and secretory processes. Often these…”
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Splicing of the VASE exon of neural cell adhesion molecule (NCAM) in human small-cell lung carcinoma (SCLC) by van Duijnhoven, H L, Helfrich, W, de Leij, L, Roebroek, A J, van de Ven, W J, Healey, K, Culverwell, A, Rossell, R J, Kemshead, J T, Patel, K

“…Expression of the neural cell adhesion molecule (NCAM) on small-cell lung carcinoma (SCLC) cell lines and tumour tissue has been investigated. Cell lines were…”
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Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes by VAN DE VEN, W. J. M, VOORBERG, J, FONTIJN, R, PANNEKOEK, H, VAN DEN OUWELAND, A. M. W, VAN DUIJNHOVEN, H. L. P, ROEBROEK, A. J. M, SIEZEN, R. J

“…The human fur gene encodes a protein, designated furin, the C-terminal half of which contains a transmembrane and a cysteine-rich receptor-like domain. The…”
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Structure of the feline c-fes/fps proto-oncogene: genesis of a retroviral oncogene by Roebroek, A.J.M, Schalken, J.A, Onnekink, C, Bloemers, H.P.J, Van de Ven, W.J.M

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Cloning and functional expression of Dfurin2, a subtilisin-like proprotein processing enzyme of Drosophila melanogaster with multiple repeats of a cysteine motif by Roebroek, A J, Creemers, J W, Pauli, I G, Kurzik-Dumke, U, Rentrop, M, Gateff, E A, Leunissen, J A, Van de Ven, W J

“…Production of a variety of regulatory eukaryotic proteins, such as growth factors and polypeptide hormones, often involves endoproteolytic processing of…”
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Human c-fms proto-oncogene: comparative analysis with an abnormal allele by VERBEEK, J. S, ROEBROEK, A. J. M, VAN DEN OUWELAND, A. M. W, BLOEMERS, H. P. J, VAN DE VEN, W. J. M

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cDNA sequence of a Drosophila melanogaster gene, Dfur1, encoding a protein structurally related to the subtilisin‐like proprotein processing enzyme furin by Roebroek, Anton J.M., Pauli, Ilse G.L., Zhang, Young, van de Ven, Wim J.M.

“…Screening a genomic library of Drosophila melanogaster DNA with a human fur cDNA probe resulted in the isolation of DNA clones that apparently belonged to two…”
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fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas by SCHALKEN, J. A, ROEBROEK, A. J. M, OOMEN, P. P. C. A, WAGENAAR, S. S, DEBRUYNE, F. M. J, BLOEMERS, H. P. J, VAN DE VEN, W. J. M

“…The recently discovered fur gene encodes a membrane-associated protein with a recognition function. To further characterize the gene, we studied its expression…”
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Generation of structural and functional diversity in furin-like proteins in Drosophila melanogaster by alternative splicing of the Dfur1 gene by Roebroek, A.J.M, Creemers, J.W.M, Pauli, I.G.L, Bogaert, T, Ven, W.J.M. van de

“…To investigate whether or not alternative splicing might be a mechanism by which in Drosophila melanogaster diversity is generated in endoproteases of the…”
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