Search Results - "Roe, M.W."

Defective glucose-dependent endoplasmic reticulum Ca2+ sequestration in diabetic mouse islets of Langerhans by Roe, M.W, Philipson, L.H, Frangakis, C.J, Kuznetsov, A, Mertz, R.J, Lancaster, M.E, Spencer, B, Worley, J.F. III, Dukes, I.D

“…Non-insulin-dependent diabetes mellitus (NIDDM) is a metabolic disease associated with abnormal insulin secretion, the underlying mechanisms of which are…”
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Assessment of Fura-2 for measurements of cytosolic free calcium by Roe, M W, Lemasters, J J, Herman, B

“…Fura-2 has become the most popular fluorescent probe with which to monitor dynamic changes in cytosolic free calcium in intact living cells. In this paper, we…”
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Endoplasmic reticulum calcium store regulates membrane potential in mouse islet beta-cells by J F Worley, 3rd, M S McIntyre, B Spencer, R J Mertz, M W Roe, I D Dukes

“…Glucose stimulation of islet beta-cell insulin secretion is initiated by membrane depolarization and an elevation in intracellular free calcium concentration…”
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Dependence on NADH produced during glycolysis for beta-cell glucose signaling by I D Dukes, M S McIntyre, R J Mertz, L H Philipson, M W Roe, B Spencer, J F Worley, 3rd

“…An increase in cytosolic ATP following glucose metabolism by pancreatic beta-cells is the key signal initiating insulin secretion by causing blockade of…”
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Voltage-dependent intracellular calcium release from mouse islets stimulated by glucose by Roe, M.W., Lancaster, M.E., Mertz, R.J., Worley, J.F., Dukes, I.D.

“…Glucose-activated beta-cell insulin secretion depends upon elevation of intracellular calcium concentration, [Ca2+]i, which is thought to arise from Ca2+…”
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Insulin and other growth factors induce binding of the ternary complex and a novel protein complex to the c-fos serum response element by THOMPSON, M. J, ROE, M. W, MALIK, R. K, BLACKSHEAR, P. J

“…Rapid, transient induction of c-fos transcription follows treatment of cells with insulin and other growth factors. This is mediated through the serum response…”
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Epidermal growth factor and other mitogens induce binding of a protein complex to the c-fos serum response element in human astrocytoma and other cells by MALIK, R. K, ROE, M. W, BLACKSHEAR, P. J

“…Rapid stimulation of c-fos transcription by many agonists requires the serum response element (SRE), which binds at least two distinct nuclear proteins, p67SRF…”
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