Search Results - "Roe, Andrew J."

Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity by Kim, Gijeong, Azmi, Liyana, Jang, Seongmin, Jung, Taeyang, Hebert, Hans, Roe, Andrew J., Byron, Olwyn, Song, Ji-Joon

“…Aldehyde-alcohol dehydrogenase (AdhE) is a key enzyme in bacterial fermentation, converting acetyl-CoA to ethanol, via two consecutive catalytic reactions…”
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Control freaks-signals and cues governing the regulation of virulence in attaching and effacing pathogens by Turner, Natasha C A, Connolly, James P R, Roe, Andrew J

“…Enterohaemorrhagic (EHEC) mediates disease using a type 3 secretion system (T3SS), which is encoded on the locus of enterocyte effacement (LEE) and is tightly…”
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LOV to BLUF： Flavoprotein Contributions to the Optogenetic Toolkit by Christie, John M., Gawthorne, Jayde, Young, Gillian, Fraser, Niall J., Roe, Andrew J.

“…Optogenetics is an emerging field that combines optical and genetic approaches to non-invasively interfere with cellular events with exquisite spatiotemporal…”
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A Highly Conserved Bacterial D-Serine Uptake System Links Host Metabolism and Virulence by Connolly, James P R, Gabrielsen, Mads, Goldstone, Robert J, Grinter, Rhys, Wang, Dai, Cogdell, Richard J, Walker, Daniel, Smith, David G E, Roe, Andrew J

“…The ability of any organism to sense and respond to challenges presented in the environment is critically important for promoting or restricting colonization…”
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Salmonella Transforms Follicle-Associated Epithelial Cells into M Cells to Promote Intestinal Invasion by Tahoun, Amin, Mahajan, Simmi, Paxton, Edith, Malterer, Georg, Donaldson, David S., Wang, Dai, Tan, Alwyn, Gillespie, Trudi L., O’Shea, Marie, Roe, Andrew J., Shaw, Darren J., Gally, David L., Lengeling, Andreas, Mabbott, Neil A., Haas, Jürgen, Mahajan, Arvind

“…Salmonella Typhimurium specifically targets antigen-sampling microfold (M) cells to translocate across the gut epithelium. Although M cells represent a…”
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Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion by Connolly, James P. R., Slater, Sabrina L., O’Boyle, Nicky, Goldstone, Robert J., Crepin, Valerie F., Ruano-Gallego, David, Herzyk, Pawel, Smith, David G. E., Douce, Gillian R., Frankel, Gad, Roe, Andrew J.

“…Niche-adaptation of a bacterial pathogen hinges on the ability to recognize the complexity of signals from the environment and integrate that information with…”
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Characterization of the Mode of Action of Aurodox, a Type III Secretion System Inhibitor from Streptomyces goldiniensis by McHugh, Rebecca E, O'Boyle, Nicky, Connolly, James P R, Hoskisson, Paul A, Roe, Andrew J

“…Recent work has demonstrated that the polyketide natural product Aurodox from is able to block the pathogenesis of the murine pathogen In this work, we aimed…”
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Propionic Acid Promotes the Virulent Phenotype of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli by Ormsby, Michael J., Johnson, Síle A., Carpena, Nuria, Meikle, Lynsey M., Goldstone, Robert J., McIntosh, Anne, Wessel, Hannah M., Hulme, Heather E., McConnachie, Ceilidh C., Connolly, James P.R., Roe, Andrew J., Hasson, Conor, Boyd, Joseph, Fitzgerald, Eamonn, Gerasimidis, Konstantinos, Morrison, Douglas, Hold, Georgina L., Hansen, Richard, Walker, Daniel, Smith, David G.E., Wall, Daniel M.

“…Propionic acid (PA) is a bacterium-derived intestinal antimicrobial and immune modulator used widely in food production and agriculture. Passage of Crohn’s…”
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From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli by Connolly, James P R, Finlay, B Brett, Roe, Andrew J

“…Enterohaemorrhagic Escherichia coli (EHEC) binds to host tissue and intimately attaches to intestinal cells using a dedicated type III secretion system (T3SS)…”
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EspF Effector, a Bacterial Pathogen's Swiss Army Knife by Holmes, Ashleigh, Mühlen, Sabrina, Roe, Andrew J, Dean, Paul

“…Central to the pathogenesis of many bacterial pathogens is the ability to deliver effector proteins directly into the cells of their eukaryotic host. EspF is…”
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Diversity in the structures and ligand-binding sites of nematode fatty acid and retinol-binding proteins revealed by Na-FAR-1 from Necator americanus by Rey-Burusco, M Florencia, Ibáñez-Shimabukuro, Marina, Gabrielsen, Mads, Franchini, Gisela R, Roe, Andrew J, Griffiths, Kate, Zhan, Bin, Cooper, Alan, Kennedy, Malcolm W, Córsico, Betina, Smith, Brian O

“…Fatty acid and retinol-binding proteins (FARs) comprise a family of unusual α-helix rich lipid-binding proteins found exclusively in nematodes. They are…”
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A Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocol by McCreath, Gordan, Whitfield, Phillip D, Roe, Andrew J, Watson, Malcolm J, Sim, Malcolm A B

“…Critically ill patients with COVID-19 are at an increased risk of developing secondary bacterial infections. These are both difficult to diagnose and are…”
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Widespread Strain-Specific Distinctions in Chromosomal Binding Dynamics of a Highly Conserved Escherichia coli Transcription Factor by Connolly, James P R, O'Boyle, Nicky, Roe, Andrew J

“…Bacterial gene regulation is governed by often hundreds of transcription factors (TFs) that bind directly to targets on the chromosome. Global studies of TFs…”
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The host metabolite D-serine contributes to bacterial niche specificity through gene selection by Connolly, James PR, Goldstone, Robert J, Burgess, Karl, Cogdell, Richard J, Beatson, Scott A, Vollmer, Waldemar, Smith, David GE, Roe, Andrew J

“…Escherichia coli comprise a diverse array of both commensals and niche-specific pathotypes. The ability to cause disease results from both carriage of specific…”
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Bacterial outer membrane vesicles provide an alternative pathway for trafficking of Escherichia coli O157 type III secreted effectors to epithelial cells by Sirisaengtaksin, Natalie, O'Donoghue, Eloise J, Jabbari, Sara, Roe, Andrew J, Krachler, Anne Marie

“…Bacteria can package protein cargo into nanosized membrane blebs that are shed from the bacterial membrane and released into the environment. Here, we report…”
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The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7 by Beckham, Katherine S. H., Connolly, James P. R., Ritchie, Jennifer M., Wang, Dai, Gawthorne, Jayde A., Tahoun, Amin, Gally, David L., Burgess, Karl, Burchmore, Richard J., Smith, Brian O., Beatson, Scott A., Byron, Olwyn, Wolfe, Alan J., Douce, Gillian R., Roe, Andrew J.

“…Summary Classical studies have focused on the role that individual regulators play in controlling virulence gene expression. An emerging theme, however, is…”
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D-Serine reduces the expression of the cytopathic genotoxin colibactin by Hallam, Jennifer C, Sandalli, Sofia, Floria, Iris, Turner, Natasha C A, Tang-Fichaux, Min, Oswald, Eric, O'Boyle, Nicky, Roe, Andrew J

“…Some strains harbour the island, a 54 kb genomic island encoding the biosynthesis genes for a genotoxic compound named colibactin. In eukaryotic cells,…”
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Author Correction: Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion by Connolly, James P. R., Slater, Sabrina L., O’Boyle, Nicky, Goldstone, Robert J., Crepin, Valerie F., Ruano-Gallego, David, Herzyk, Pawel, Smith, David G. E., Douce, Gillian R., Frankel, Gad, Roe, Andrew J.

“…The original version of this Article contained an error in the spelling of the author David Ruano-Gallego, which was incorrectly given as David R. Gallego…”
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Mapping the Transcriptome Underpinning Acute Corticosteroid Action within the Cortical Collecting Duct by Loughlin, Struan, Costello, Hannah M, Roe, Andrew J, Buckley, Charlotte, Wilson, Stuart M, Bailey, Matthew A, Mansley, Morag K

“…Key Points We report the transcriptomes associated with acute corticosteroid regulation of ENaC activity in polarized mCCD cl1 collecting duct cells. Nine…”
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Current understandings of colibactin regulation by Addington, Emily, Sandalli, Sofia, Roe, Andrew J

“…The biosynthetic machinery for the production of colibactin is encoded by 19 genes ( ) within the pathogenicity island harboured by many of the B2-phylogroup…”
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