Search Results - "Roduit, Raphael"

Mutations in the DNA-binding domain of NR2E3 affect in vivo dimerization and interaction with CRX by Roduit, Raphael, Escher, Pascal, Schorderet, Daniel F

“…NR2E3 (PNR) is an orphan nuclear receptor essential for proper photoreceptor determination and differentiation. In humans, mutations in NR2E3 have been…”
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Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure by ABDELLI, Saida, ANSITE, Jeff, BONNY, Christophe, RODUIT, Raphael, BORSELLO, Tiziana, MATSUMOTO, Ippei, SAWADA, Toshiya, ALLAMAN-PILLET, Nathalie, HENRY, Hugues, BECKMANN, Jacques S, HERING, Bernhard J

“…Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure Saida Abdelli 1 , Jeff Ansite 2 ,…”
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MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells by Roduit, Raphaël, Schorderet, Daniel F

“…The retinal pigment epithelium (RPE) is constantly exposed to external injuries which lead to degeneration, dysfunction or loss of RPE cells. The balance…”
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GSH-Independent Induction of ER Stress during Hypoglycaemia in the Retinal Cells of Mice by Fresia, Daria, Cannizzaro, Enrica, Borgo, Angelica, Roduit, Raphaël

“…Glucose is one of the most important metabolic substrates of the retina, and glycaemic imbalances can lead to serious side effects, including retinopathy. We…”
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Insulin Secretion is Regulated by the Glucose-Dependent Production of Islet β Cell Macrophage Migration Inhibitory Factor by Waeber, Gerard, Calandra, Thierry, Roduit, Raphael, Haefliger, Jacques-Antoine, Bonny, Christophe, Thompson, Nancy, Thorens, Bernard, Temler, Evelyne, Meinhardt, Andreas, Bacher, Michael, Metz, Christine N., Nicod, Pascal, Bucala, Richard

“…Macrophage migration inhibitory factor (MIF), originally identified as a cytokine secreted by T lymphocytes, was found recently to be both a pituitary hormone…”
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Biological Characterization of Gene Response to Insulin-Induced Hypoglycemia in Mouse Retina by Emery, Martine, Nanchen, Natacha, Preitner, Frédéric, Ibberson, Mark, Roduit, Raphaël

“…Glucose is the most important metabolic substrate of the retina and maintenance of normoglycemia is an essential challenge for diabetic patients. Chronic,…”
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Molecular Biomarkers of Neovascular Age-Related Macular Degeneration With Incomplete Response to Anti-Vascular Endothelial Growth Factor Treatment by Mantel, Irmela, Borgo, Angelica, Guidotti, Jacopo, Forestier, Edwige, Kirsch, Olga, Derradji, Yasmine, Waridel, Patrice, Burdet, Frédéric, Mehl, Florence, Schweizer, Claude, Roduit, Raphaël

“…The standard treatment for neovascular age-related macular degeneration (nAMD) consists of intravitreal anti-vascular endothelial growth factors (VEGF)…”
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A Role for the Malonyl-CoA/Long-Chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli by RODUIT, Raphaël, NOLAN, Christopher, RUDERMAN, Neil, RHODES, Christopher, POITOUT, Vincent, PRENTKI, Marc, ALARCON, Cristina, MOORE, Patrick, BARBEAU, Annie, DELGHINGARO-AUGUSTO, Viviane, PRZYBYKOWSKI, Ewa, MORIN, Johane, MASSE, Frédéric, MASSIE, Bernard

“…A Role for the Malonyl-CoA/Long-Chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli…”
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Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes by Prentki, Marc, Joly, Erik, El-Assaad, Wissal, Roduit, Raphaël

“…Beta-cells possess inherent mechanisms to adapt to overnutrition and the prevailing concentrations of glucose, fatty acids, and other fuels to maintain glucose…”
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Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration by Pyakurel, Aswin, Balmer, Delphine, Saba-El-Leil, Marc K., Kizilyaprak, Caroline, Daraspe, Jean, Humbel, Bruno M., Voisin, Laure, Le, Yun Z., von Lintig, Johannes, Meloche, Sylvain, Roduit, Raphaël

“…Recent work suggested that the activity of extracellular signal-regulated kinase 1/2 (ERK1/2) is increased in the retinal pigment epithelium (RPE) of…”
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Autophagy defect is associated with low glucose-induced apoptosis in 661W photoreceptor cells by Balmer, Delphine, Emery, Martine, Andreux, Pénélope, Auwerx, Johan, Ginet, Vanessa, Puyal, Julien, Schorderet, Daniel F, Roduit, Raphaël

“…Glucose is an important metabolic substrate of the retina and diabetic patients have to maintain a strict normoglycemia to avoid diabetes secondary effects,…”
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Acute hypoglycemia induces retinal cell death in mouse by Emery, Martine, Schorderet, Daniel F, Roduit, Raphaël

“…Glucose is the most important metabolic substrate of the retina and maintenance of normoglycemia is an essential challenge for diabetic patients. Glycemic…”
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Lipoprotein Lipase and Leptin Are Accumulated in Different Secretory Compartments in Rat Adipocytes by Roh, Cecilia, Roduit, Raphael, Thorens, Bernard, Fried, Susan, Kandror, Konstantin V.

“…Adipose cells produce and secrete several physiologically important proteins, such as lipoprotein lipase (LPL), leptin, adipsin, Acrp30, etc. However,…”
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DcR3/TR6 Effectively Prevents Islet Primary Nonfunction After Transplantation by YULIAN WU, BING HAN, HONGYU LUO, RODUIT, Raphael, SALCEDO, Theodora W, MOORE, Paul A, JUN ZHANG, JIANGPING WU

“…DcR3/TR6 Effectively Prevents Islet Primary Nonfunction After Transplantation Yulian Wu 1 2 , Bing Han 2 , Hongyu Luo 1 , Raphael Roduit 3 , Theodora W…”
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CNGB3 Missense Variant Causes Recessive Achromatopsia in Original Braunvieh Cattle by Häfliger, Irene M, Marchionatti, Emma, Stengård, Michele, Wolf-Hofstetter, Sonja, Paris, Julia M, Jacinto, Joana G P, Watté, Christine, Voelter, Katrin, Occelli, Laurence M, Komáromy, András M, Oevermann, Anna, Goepfert, Christine, Borgo, Angelica, Roduit, Raphaël, Spengeler, Mirjam, Seefried, Franz R, Drögemüller, Cord

“…Sporadic occurrence of inherited eye disorders has been reported in cattle but so far pathogenic variants were found only for rare forms of cataract but not…”
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Calcium- and Proteasome-dependent Degradation of the JNK Scaffold Protein Islet-brain 1 by Allaman-Pillet, Nathalie, Størling, Joachim, Oberson, Anne, Roduit, Raphael, Negri, Stéphanie, Sauser, Christelle, Nicod, Pascal, Beckmann, Jacques S., Schorderet, Daniel F., Mandrup-Poulsen, Thomas, Bonny, Christophe

“…In models of type 1 diabetes, cytokines induce pancreatic β-cell death by apoptosis. This process seems to be facilitated by a reduction in the amount of the…”
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Pancreatic Islet Adaptation to Fasting Is Dependent on Peroxisome Proliferator-Activated Receptor α Transcriptional Up-Regulation of Fatty Acid Oxidation by Gremlich, Sandrine, Nolan, Christopher, Roduit, Raphaël, Burcelin, Rémy, Peyot, Marie-Line, Delghingaro-Augusto, Viviane, Desvergne, Béatrice, Michalik, Liliane, Prentki, Marc, Wahli, Walter

“…The cellular response to fasting and starvation in tissues such as heart, skeletal muscle, and liver requires peroxisome proliferator-activated receptor-α…”
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Mutations in NR2E3 can cause dominant or recessive retinal degenerations in the same family by Escher, Pascal, Gouras, Peter, Roduit, Raphaël, Tiab, Leila, Bolay, Sylvain, Delarive, Tania, Chen, Shiming, Tsai, Chih-Cheng, Hayashi, Masanori, Zernant, Jana, Merriam, Joanna E, Mermod, Nicolas, Allikmets, Rando, Munier, Francis L, Schorderet, Daniel F

“…NR2E3, a photoreceptor-specific nuclear receptor (PNR), represses cone-specific genes and activates several rod-specific genes. In humans, mutations in NR2E3…”
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Complement Factor B Polymorphism and the Phenotype of Early Age-related Macular Degeneration by Mantel, Irmela, Ambresin, Aude, Moetteli, Leila, Droz, Ivaine, Roduit, Raphaël, Munier, Francis L., Schorderet, Daniel F.

“…Abstract Purpose: Age-related macular degeneration (AMD) has been associated with a number of polymorphisms in genes in the complement pathway. We examined the…”
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Glucose and leptin induce apoptosis in human β-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases by Maedler, Kathrin, Schulthess, Fabienne T, Bielman, Christelle, Berney, Thierry, Bonny, Christophe, Prentki, Marc, Donath, Marc Y, Roduit, Raphael

“…c-Jun N-terminal kinases (SAPK/JNKs) are activated by inflammatory cytokines, and JNK signaling is involved in insulin resistance and β-cell secretory function…”
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