Search Results - "Rodriguez, Olga C."
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Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury
Published in Molecular neurodegeneration (04-04-2018)“…Traumatic Brain Injury (TBI) is a major cause of disability and mortality, to which there is currently no comprehensive treatment. Blood Brain Barrier (BBB)…”
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Divergent brain changes in two audiogenic rat strains: A voxel-based morphometry and diffusion tensor imaging comparison of the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR)
Published in Neurobiology of disease (01-03-2018)“…Acoustically evoked seizures (e.g., audiogenic seizures or AGS) are common in models of inherited epilepsy and occur in a variety of species including rat,…”
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3
Conserved microtubule-actin interactions in cell movement and morphogenesis
Published in Nature cell biology (01-07-2003)“…Interactions between microtubules and actin are a basic phenomenon that underlies many fundamental processes in which dynamic cellular asymmetries need to be…”
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Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production
Published in Aging (Albany, NY.) (06-08-2013)“…Despite recent epidemiological evidences linking radiation exposure and a number of human ailments including cancer, mechanistic understanding of how radiation…”
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5
Magnetic Nanobeads as Potential Contrast Agents for Magnetic Resonance Imaging
Published in ACS nano (22-10-2013)“…Metal-oxo clusters have been used as building blocks to form hybrid nanomaterials and evaluated as potential MRI contrast agents. We have synthesized a…”
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Human myosin-Vc is a novel class V myosin expressed in epithelial cells
Published in Journal of cell science (01-03-2002)“…Class V myosins are one of the most ancient and widely distributed groups of the myosin superfamily and are hypothesized to function as motors for…”
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The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells
Published in Aging (Albany, NY.) (27-10-2015)“…Medulloblastoma (MB), a primitive neuroectodermal tumor, is the most common malignant childhood brain tumor and remains incurable in about a third of patients…”
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8
The Abl-related gene tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin
Published in Molecular biology of the cell (01-10-2007)“…In migrating cells, actin polymerization promotes protrusion of the leading edge, whereas actomyosin contractility powers net cell body translocation. Although…”
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9
Detoxification: A Novel Function of BRCA1 in Tumor Suppression?
Published in Toxicological sciences (01-07-2011)“…Our studies found that BRCA1 levels negatively correlate with DNA adducts induced by Benzo(a)pyrene (BaP). Pulse-chase experiments showed that the increase in…”
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10
3367 A Mouse Model of APOE Genotype in Chemotherapy Related Cognitive Impairment
Published in Journal of clinical and translational science (01-03-2019)“…OBJECTIVES/SPECIFIC AIMS: Chemotherapy-related cognitive impairment (CRCI) affects 15-35% of breast cancer survivors and constitutes a significant challenge…”
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Magnetic Microdevices for MRI-Based Detection of SARS-CoV-2 Viruses
Published in IEEE open journal of engineering in medicine and biology (01-01-2020)“…Goal: To develop a micron-scale device that can operate as an MRI-based reporter for the presence of SARS-CoV-2 virus. Methods: Iron rod microdevices were…”
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Dietary n-3 polyunsaturated fatty acids fail to reduce prostate tumorigenesis in the PB-ErbB-2 x Pten+/- preclinical mouse model
Published in Cell cycle (Georgetown, Tex.) (01-05-2010)“…Diet and obesity, and their associated metabolic alterations, are some of the fastest-growing causes of disease and death in America. Findings from…”
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SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker
Published in Oncotarget (15-03-2014)“…Mutations of the p53 gene hallmark many human cancers. Several p53 mutant proteins acquire the capability to promote cancer progression and metastasis, a…”
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14
ErbB-2 Induces Bilateral Adrenal Pheochromocytoma Formation in Mice
Published in Cell cycle (Georgetown, Tex.) (01-08-2007)“…Pheochromocytoma (PCC) is a rare catecholamine-producing tumor that arises from the adrenal medulla and is often familial. The genetic basis for familial PCC…”
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VBP15, a novel anti‐inflammatory and membrane‐stabilizer, improves muscular dystrophy without side effects
Published in EMBO molecular medicine (01-10-2013)“…Absence of dystrophin makes skeletal muscle more susceptible to injury, resulting in breaches of the plasma membrane and chronic inflammation in Duchenne…”
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Neuropeptide Y as a Biomarker and Therapeutic Target for Neuroblastoma
Published in The American journal of pathology (01-11-2016)“…Neuroblastoma (NB) is a pediatric malignant neoplasm of sympathoadrenal origin. Challenges in its management include stratification of this heterogeneous…”
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Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells
Published in Oncotarget (30-03-2014)“…Strigolactones are a novel class of plant hormones produced in roots and regulate shoot and root development. We have previously shown that synthetic…”
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Preclinical magnetic resonance imaging and systems biology in cancer research: current applications and challenges
Published in The American journal of pathology (01-02-2013)“…Biologically accurate mouse models of human cancer have become important tools for the study of human disease. The anatomical location of various target…”
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Addition of forelimb training reduces gains from robotic gait training in a rat model of spinal cord injury
Published in 2017 International Conference on Rehabilitation Robotics (ICORR) (01-07-2017)“…To restore locomotor function following spinal cord injury the disrupted descending supraspinal drive needs to be re-connected to regions caudal to the injury…”
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In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
Published in Journal of visualized experiments (09-12-2016)“…Hypoxia has been implicated in the metastasis of Ewing sarcoma (ES) by clinical observations and in vitro data, yet direct evidence for its pro-metastatic…”
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