Search Results - "Rodrigues da Silva, Rodrigo Nunes"

Leptospira Leptolysin Contributes to Serum Resistance but Is Not Essential for Acute Infection by Santos Courrol, Daniella, Santos, Cassia Moreira, Chura‐Chambi, Rosa Maria, Morganti, Lígia, Avelar, Kátia Eliane Santos, Moraes Maia, Fernanda, Rodrigues‐da‐Silva, Rodrigo Nunes, Wunder, Elsio Augusto, Barbosa, Angela Silva

“…ABSTRACT Previous in vitro works focusing on virulence determinants of the spirochete Leptospira implicated metalloproteinases as putative contributing factors…”
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Main B‐cell epitopes of PvAMA‐1 and PvMSP‐9 are targeted by naturally acquired antibodies and epitope‐specific memory cells in acute and convalescent phases of vivax malaria by Soares, Roberta Reis, Nakaie, Clovis Ryuichi, Rodrigues‐da‐Silva, Rodrigo Nunes, Silva, Rogério Lauria, Lima‐Junior, Josué da Costa, Scopel, Kézia Katiani Gorza

“…Although antibodies are considered critical for malaria protection, little is known about the mechanisms/factors that maintain humoral immunity, especially…”
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Apical membrane protein 1‐specific antibody profile and temporal changes in peripheral blood B‐cell populations in Plasmodium vivax malaria by Soares, Roberta Reis, Cunha, Clarissa F., Ferraz‐Nogueira, Raquel, Marins‐dos‐Santos, Alessandro, Rodrigues‐da‐Silva, Rodrigo Nunes, Soares, Irene, Lima‐Junior, Josué, Bertho, Alvaro Luiz, Ferreira, Marcelo Urbano, Scopel, Kézia Katiani Gorza

“…Plasmodium falciparum‐specific antibodies tend to be short‐lived, but their cognate memory B cells (MBCs) circulate in the peripheral blood of exposed subjects…”
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Characterization of T and B cell epitopes in PvCyRPA by studying the naturally acquired immune response in Brazilian Amazon communities by Soares, Isabela Ferreira, de Oliveira Baptista, Barbara, da Silva Matos, Ada, Rodrigues-da-Silva, Rodrigo Nunes, Kujbida Junior, Mario Antonio, Albrecht, Letusa, Rodolphi, Cinthia Magalhães, Scopel, Kézia Katiani Gorza, Alencar, Ana Luiza Carneiro, de Souza, Rodrigo Medeiros, dos Santos de Souza, Hugo Amorim, Riccio, Evelyn Kety Pratt, de Barros, Jenifer Peixoto, Totino, Paulo Renato Rivas, Daniel-Ribeiro, Cláudio Tadeu, Pratt-Riccio, Lilian Rose, Lima-Junior, Josué da Costa

“…Plasmodium vivax , a challenging species to eliminate, causes millions of malaria cases globally annually. Developing an effective vaccine is crucial in the…”
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Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection by Arcanjo, Angélica, Guimarães Pinto, Kamila, Logullo, Jorgete, Leite, Paulo Emílio Corrêa, Menezes, Camilla Cristie Barreto, Freire-de-Lima, Leonardo, Diniz-Lima, Israel, Decoté-Ricardo, Debora, Nunes Rodrigues-da-Silva, Rodrigo, Geraldo Freire-de-Lima, Celio, Almeida Filardy, Alessandra, Lima-Junior, Josué da Costa, Luiz Bertho, Alvaro, De Luca, Paula Mello, Mauro Granjeiro, José, Coutinho Barroso, Shana Priscila, Conceição-Silva, Fátima, Savino, Wilson, Morrot, Alexandre

“…BACKGROUNDCoronavirus disease 2019 (COVID-19) can progress to severe pneumonia with respiratory failure and is aggravated by the deregulation of the immune…”
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Construction, Expression, and Evaluation of the Naturally Acquired Humoral Immune Response against Plasmodium vivax RMC-1, a Multistage Chimeric Protein by Matos, Ada da Silva, Soares, Isabela Ferreira, Baptista, Barbara de Oliveira, de Souza, Hugo Amorim Dos Santos, Chaves, Lana Bitencourt, Perce-da-Silva, Daiana de Souza, Riccio, Evelyn Kety Pratt, Albrecht, Letusa, Totino, Paulo Renato Rivas, Rodrigues-da-Silva, Rodrigo Nunes, Daniel-Ribeiro, Cláudio Tadeu, Pratt-Riccio, Lilian Rose, Lima-Junior, Josué da Costa

“…The PvCelTOS, PvCyRPA, and Pvs25 proteins play important roles during the three stages of the lifecycle. In this study, we designed and expressed a recombinant…”
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Immunogenicity of synthetic peptide constructs based on PvMSP9E795-A808, a linear B-cell epitope of the P. vivax Merozoite Surface Protein-9 by Rodrigues-da-Silva, Rodrigo Nunes, Correa-Moreira, Daniely, Soares, Isabela Ferreira, de-Luca, Paula Melo, Totino, Paulo Renato Rivas, Morgado, Fernanda Nazaré, Oliveira Henriques, Maria das Graças de, Peixoto Candea, André Luis, Singh, Balwan, Galinski, Mary R., Moreno, Alberto, Oliveira-Ferreira, Joseli, Lima-Junior, Josué da Costa

“…•PvMSp9E795-A808 synthetic constructs were immunogenic in mice.•IgG1, IgG2a and IgG2b were prevalent in humoral response induced by synthetic peptides.•T-cell…”
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Immunogenicity of PvCyRPA, PvCelTOS and Pvs25 chimeric recombinant protein of Plasmodium vivax in murine model by Matos, Ada da Silva, Soares, Isabela Ferreira, Rodrigues-da-Silva, Rodrigo Nunes, Rodolphi, Cinthia Magalhães, Albrecht, Letusa, Donassolo, Rafael Amaral, Lopez-Camacho, Cesar, Ano Bom, Ana Paula Dinis, Neves, Patrícia Cristina da Costa, Conte, Fernando de Paiva, Pratt-Riccio, Lilian Rose, Daniel-Ribeiro, Cláudio Tadeu, Totino, Paulo Renato Rivas, Lima-Junior, Josué da Costa

“…In the Americas, is the predominant causative species of malaria, a debilitating and economically significant disease. Due to the complexity of the malaria…”
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Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome by Conte, Fernando de Paiva, Tinoco, Bianca Corrêa, Santos Chaves, Thiago, Oliveira, Renata Carvalho de, Figueira Mansur, Janaina, Mohana-Borges, Ronaldo, Lemos, Elba Regina Sampaio de, Neves, Patricia Cristina da Costa, Rodrigues-da-Silva, Rodrigo Nunes

“…Orthohantavirus infection is a neglected global health problem affecting approximately 200,000 people/year, spread by rodent hosts and associated to fatal…”
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Changes in B Cell Pool of Patients With Multibacillary Leprosy: Diminished Memory B Cell and Enhanced Mature B in Peripheral Blood by Nogueira, Otto Castro, Gandini, Mariana, Cabral, Natasha, de Figueiredo, Vilma, Rodrigues-da-Silva, Rodrigo Nunes, Lima-Junior, Josué da Costa, Pinheiro, Roberta Olmo, Pereira, Geraldo Moura Batista, Pessolani, Maria Cristina Vidal, de Macedo, Cristiana Santos

“…Despite being treatable, leprosy still represents a major public health problem, and many mechanisms that drive leprosy immunopathogenesis still need to be…”
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The Serological Cross-Detection of Bat-Borne Hantaviruses: A Valid Strategy or Taking Chances? by de Oliveira, Renata Carvalho, Fernandes, Jorlan, de Sampaio Lemos, Elba Regina, de Paiva Conte, Fernando, Rodrigues-da-Silva, Rodrigo Nunes

“…Bats are hosts of a range of viruses, and their great diversity and unique characteristics that distinguish them from all other mammals have been related to…”
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Leptolysin, a Leptospira secreted metalloprotease of the pappalysin family with broad-spectrum activity by Courrol, Daniella dos Santos, Silva, Cristiane Castilho Fernandes da, Prado, Luan Gavião, Chura-Chambi, Rosa Maria, Morganti, Ligia, de Souza, Gisele Oliveira, Heinemann, Marcos Bryan, Isaac, Lourdes, Conte, Fernando Paiva, Portaro, Fernanda Calheta Vieira, Rodrigues-da-Silva, Rodrigo Nunes, Barbosa, Angela Silva

“…Extracellular proteolytic enzymes are produced by a variety of pathogenic microorganisms, and contribute to host colonization by modulating virulence. Here, we…”
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In silico Identification and Validation of a Linear and Naturally Immunogenic B-Cell Epitope of the Plasmodium vivax Malaria Vaccine Candidate Merozoite Surface Protein-9 by Rodrigues-da-Silva, Rodrigo Nunes, Martins da Silva, João Hermínio, Singh, Balwan, Jiang, Jianlin, Meyer, Esmeralda V S, Santos, Fátima, Banic, Dalma Maria, Moreno, Alberto, Galinski, Mary R, Oliveira-Ferreira, Joseli, Lima-Junior, Josué da Costa

“…Synthetic peptide vaccines provide the advantages of safety, stability and low cost. The success of this approach is highly dependent on efficient epitope…”
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Immunogenicity of synthetic peptide constructs based on PvMSP9 E795-A808 , a linear B-cell epitope of the P. vivax Merozoite Surface Protein-9 by Rodrigues-da-Silva, Rodrigo Nunes, Correa-Moreira, Daniely, Soares, Isabela Ferreira, de-Luca, Paula Melo, Totino, Paulo Renato Rivas, Morgado, Fernanda Nazaré, Oliveira Henriques, Maria das Graças de, Peixoto Candea, André Luis, Singh, Balwan, Galinski, Mary R, Moreno, Alberto, Oliveira-Ferreira, Joseli, Lima-Junior, Josué da Costa

“…Plasmodium vivax Merozoite Surface Protein-9 (PvMSP-9) is a malaria vaccine candidate naturally immunogenic in humans and able to induce high antibody titers…”
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Dynamics of IgM and IgG Antibody Response Profile against Linear B-Cell Epitopes from Exoerythrocytic (CelTOS and TRAP) and Erythrocytic (CyRPA) Phases of Plasmodium vivax : Follow-Up Study by Rodolphi, Cinthia Magalhães, Soares, Isabela Ferreira, Matos, Ada da Silva, Rodrigues-da-Silva, Rodrigo Nunes, Ferreira, Marcelo Urbano, Pratt-Riccio, Lilian Rose, Totino, Paulo Renato Rivas, Scopel, Kézia Katiani Gorza, Lima-Junior, Josué da Costa

“…Malaria is a serious health problem worldwide affecting mainly children and socially vulnerable people. The biological particularities of , such as the ability…”
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Sph2 (176-191) and Sph2 (446-459) : Identification of B-Cell Linear Epitopes in Sphingomyelinase 2 (Sph2), Naturally Recognized by Patients Infected by Pathogenic Leptospires by Ataides, Laura Sant'Anna, de Moraes Maia, Fernanda, Conte, Fernando Paiva, Isaac, Lourdes, Barbosa, Angela Silva, da Costa Lima-Junior, Josué, Avelar, Kátia Eliane Santos, Rodrigues-da-Silva, Rodrigo Nunes

“…Sphingomyelin is a major constituent of eukaryotic cell membranes, and if degraded by bacteria sphingomyelinases may contribute to the pathogenesis of…”
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Antibody Responses Against Plasmodium vivax TRAP Recombinant and Synthetic Antigens in Naturally Exposed Individuals From the Brazilian Amazon by Matos, Ada da Silva, Rodrigues-da-Silva, Rodrigo Nunes, Soares, Isabela Ferreira, Baptista, Barbara de Oliveira, de Souza, Rodrigo Medeiros, Bitencourt-Chaves, Lana, Totino, Paulo Renato Rivas, Sánchez-Arcila, Juan Camilo, Daniel-Ribeiro, Cláudio Tadeu, López-Camacho, César, Reyes-Sandoval, Arturo, Pratt-Riccio, Lilian Rose, Lima-Junior, Josué da Costa

“…Thrombospondin-related adhesive protein (TRAP) is essential for sporozoite motility and the invasion of mosquitoes' salivary gland and vertebrate's hepatocyte…”
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Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections by Rodrigues-da-Silva, Rodrigo Nunes, Lima-Junior, Josué da Costa, de Paula Fonseca e Fonseca, Bruna, Antas, Paulo Renato Zuquim, Baldez, Arlete, Storer, Fabio Luiz, Santos, Fátima, Banic, Dalma Maria, de Oliveira-Ferreira, Joseli

“…Haematological and cytokine alterations in malaria are a broad and controversial subject in the literature. However, few studies have simultaneously evaluated…”
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Leishmania infantum Virulence Factor A2 Protein: Linear B-Cell Epitope Mapping and Identification of Three Main Linear B-Cell Epitopes in Vaccinated and Naturally Infected Dogs by Campos, Monique Paiva, Figueiredo, Fabiano Borges, Morgado, Fernanda Nazaré, Renzetti, Alinne Rangel Dos Santos, de Souza, Sara Maria Marques, Pereira, Sandro Antônio, Rodrigues-Da-Silva, Rodrigo Nunes, Lima-Junior, Josué Da Costa, De Luca, Paula Mello

“…In Brazil, canine visceral leishmaniasis (CVL) is caused by Leishmania infantum, presenting a broad spectrum of clinical manifestations. Dogs are the main…”
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Genetic Diversity of Plasmodium vivax Cysteine-Rich Protective Antigen (PvCyRPA) in Field Isolates from Five Different Areas of the Brazilian Amazon by Bitencourt Chaves, Lana, Guimarães, Glaucia de Oliveira, Perce-da-Silva, Daiana de Souza, Banic, Dalma Maria, Totino, Paulo Renato Rivas, Machado, Ricardo Luiz Dantas, Rodrigues-da-Silva, Rodrigo Nunes, Pratt-Riccio, Lilian Rose, Daniel-Ribeiro, Cláudio Tadeu, Lima-Junior, Josué da Costa

“…The Cysteine-Rich Protective Antigen (PvCyRPA) has an important role in erythrocyte invasion and has been considered a target for malaria vaccine development…”
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